Glutamate-induced action potentials are preceded by regenerative prepotentials in rat hippocampal pyramidal cells in vitro.

Abstract:

:(1) The responses of CA1 pyramidal cells to short glutamate pulses (10-50 ms) delivered at sensitive spots in the apical dendrites have been analysed by intracellular recording. (2) The glutamate pulses elicited stable depolarizing responses in a dose- and frequency-dependent manner. (3) When a single action potential with a firing probability around 0.5 was elicited, a subtraction procedure showed that a slow depolarizing ramp preceded each spike. We call this ramp the glutamate-induced prepotential (GluPP). (4) In contrast to the upward convex subthreshold depolarization the GluPP was upward concave. (5) The GluPP amplitude and time course increased with depolarization of the membrane, a phenomenon which appears to be connected to the elevation of action potential threshold. (6) The GluPP was regenerative since once started, it ended in an action potential. (7) A specific N-methyl-D-aspartate receptor antagonist, DL-2-amino-5-phosphonovaleric acid (50 microM) reduced the glutamate-induced depolarization, but did not affect the form or amplitude of GluPP, once the latter was induced. (8) It is concluded that short glutamate pulses elicited action potentials through a prepotential mechanism, similar to the slow prepotentials induced by long depolarizing current pulses across the soma membrane. (9) A possible physiological role for the GluPP is discussed.

journal_name

Exp Brain Res

authors

Hu GY,Hvalby O

doi

10.1007/BF00228178

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

485-94

issue

3

eissn

0014-4819

issn

1432-1106

journal_volume

88

pub_type

杂志文章
  • Effects of damage to superior colliculi and pre-tectum on movement discrimination in rhesus monkeys.

    abstract::Eight rhesus monkeys (Macaca mulatta) were trained to detect an instantaneous lateral displacement of a small spot of light. The smallest movement for 79% correct performance was then determined. Severing the splenium of the corpus callosum, which has to be done to reveal the superior colliculi, had no effect on the m...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00237444

    authors: Cowey A,Smith B,Butter CM

    更新日期:1984-01-01 00:00:00

  • Initiation of smooth-pursuit eye movements to first-order and second-order motion stimuli.

    abstract::Since normal human subjects can perform smooth-pursuit eye movements only in the presence of a moving target, the occurrence of these eye movements represents an ideal behavioural probe to monitor the successful processing of visual motion. It has been shown previously that subjects can execute smooth-pursuit eye move...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000459

    authors: Lindner A,Ilg UJ

    更新日期:2000-08-01 00:00:00

  • Suppressive musculocutaneous reflexes in tibialis anterior following upper leg stimulation at the end of the swing phase.

    abstract::In the cat it is known that the distribution and modulation of the so-called P2 responses are similar, irrespective of whether they are obtained with electrodes implanted in the different skin areas or in the various leg muscles. In man it is known that the specific stimulation of cutaneous afferents from different pa...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-002-1366-4

    authors: Van de Crommert HW,Steijvers PJ,Mulder T,Duysens J

    更新日期:2003-04-01 00:00:00

  • Grabbing subitizing with both hands: bimanual number processing.

    abstract::Visual judgment of small numerosities (<4) is generally assumed to be done through subitizing, which is a faster process than counting. Subitizing has also been shown to occur in haptic judgment of the number of spheres in the hand. Furthermore, interactions have been shown to exist between visually perceived numbers ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2146-1

    authors: Plaisier MA,Tiest WM,Kappers AM

    更新日期:2010-04-01 00:00:00

  • Monocular and binocular control of human interceptive movements.

    abstract::Previous work in our laboratory has demonstrated that binocular vision makes an important contribution to skilled reaching and grasping movements directed at static targets. In the present study we examine the contribution of binocular vision to interceptive reaching movements. We monitored such movements using a high...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002210050323

    authors: Servos P,Goodale MA

    更新日期:1998-03-01 00:00:00

  • Early manifestation of arm-leg coordination during stepping on a surface in human neonates.

    abstract::The accomplishment of mature locomotor movements relies upon the integrated coordination of the lower and upper limbs and the trunk. Human adults normally swing their arms and a quadrupedal limb coordination persists during bipedal walking despite a strong corticospinal control of the upper extremities that allows to ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5201-y

    authors: La Scaleia V,Ivanenko Y,Fabiano A,Sylos-Labini F,Cappellini G,Picone S,Paolillo P,Di Paolo A,Lacquaniti F

    更新日期:2018-04-01 00:00:00

  • Shifts of cortical d.c. potential induced by application of gamma-aminobutyric acid in rats in vivo.

    abstract::Generally, increases in cortical activity go in parallel with negative shifts and decreases with positive shifts of cortical d.c. potentials. The aim of the present investigation was to test the effects of the inhibitory transmitter gamma-aminobutyric acid (GABA) and of GABA receptor agonists on cortical d.c. potentia...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/pl00005614

    authors: Lücke A,Woesler B,Speckmann EJ

    更新日期:1997-03-01 00:00:00

  • Modulation of corticospinal excitability during lengthening and shortening contractions in the first dorsal interosseus muscle of humans.

    abstract::Lengthening and shortening contractions are the fundamental patterns of muscle activation underlying various movements. It is still unknown whether or not there is a muscle-specific difference in such a fundamental pattern of muscle activation. The purpose of this study was, therefore, to investigate whether or not th...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0743-9

    authors: Sekiguchi H,Kohno Y,Hirano T,Akai M,Nakajima Y,Nakazawa K

    更新日期:2007-04-01 00:00:00

  • Dopaminergic effects on the implicit processing of distractor objects in Parkinson's disease.

    abstract::The aim of the present study was to assess the effects of dopaminergic medication on the selection-for-action mechanisms in Parkinson's disease (PD). PD subjects were tested after not having taken medication for at least 12 h ("Off' state) and then retested 1-2 h after medication ("On" state). A three-dimensional kine...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000510

    authors: Castiello U,Bonfiglioli C,Peppard RF

    更新日期:2000-11-01 00:00:00

  • The retinotopic match between area 17 and its targets in visual suprasylvian cortex.

    abstract::It is widely believed that cells in area 17 send axons specifically to neurons in other cortical areas whose receptive fields coincide with their own. We asked whether this was true in cats for area 17's projection to a large suprasylvian visual area, the Clare-Bishop area. Receptive fields were plotted at multiple si...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00250246

    authors: Sherk H,Ombrellaro M

    更新日期:1988-01-01 00:00:00

  • Involuntary inhibition of movement initiation alters oculomotor competition resolution.

    abstract::Identifying a stimulus as the target for a goal-directed movement involves inhibiting competing responses. Separable inhibitory interconnections bias local competition to ensure only one stimulus is selected and to alter movement initiation. Behavioural evidence of these inhibitory processes comes from the effects of ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-008-1645-9

    authors: Cruickshank AG,McSorley E

    更新日期:2009-03-01 00:00:00

  • Apparent motion during saccadic suppression periods.

    abstract::Sensitivity to many visual stimuli, and, in particular, image displacement, is reduced during a change in fixation (saccade) compared to when the eye is still. In these experiments, we studied the sensitivity of observers to ecologically relevant image translations of large, complex, real world scenes either during ho...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2120-y

    authors: Allison RS,Schumacher J,Sadr S,Herpers R

    更新日期:2010-04-01 00:00:00

  • Neural site of strabismic amblyopia in cats: X-cell acuities in the LGN.

    abstract::The acuities of X-cells from the dorsal lateral geniculate nucleus (LGN) were measured in five cats raised with a convergent strabismus, surgically induced by tenotomy. The acuities of cells driven by the strabismic eye were not significantly different from the acuities of cells driven by the non-deviating eye over th...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00250595

    authors: Gillard-Crewther S,Crewther DP

    更新日期:1988-01-01 00:00:00

  • The marginal nuclei of the spinal cord in turtles: neuron assemblies in which gamma-aminobutyric acid and nitric oxide synthase are colocalized.

    abstract::Conspicuous nerve-cell assemblies, identified as the marginal nuclei described in other sauropsidans, were found all along the spinal cord of turtles. gamma-aminobutyric acid (GABA) and nitric oxide synthase (NOS) activities were colocalized within these neurons, which also reacted positively to reduced nicotinamide a...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050499

    authors: Fernández A,Radmilovich M,Trujillo-Cenóz O

    更新日期:1998-09-01 00:00:00

  • Cyclic modulation of the H-reflex in a wrist flexor during rhythmic flexion-extension movements of the ipsilateral foot.

    abstract::In 12 subjects, each sitting on an armchair with the right forearm prone, the H-reflex elicited in the resting flexor carpi radialis muscle underwent cyclic excitability changes correlated with rhythmic flexion-extension movements of the ipsilateral foot (frequency of oscillations between 1.5 and 2.5 Hz). During foot ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050297

    authors: Baldissera F,Cavallari P,Leocani L

    更新日期:1998-02-01 00:00:00

  • Simultaneous recording of lagged and nonlagged cells in the cat dorsal lateral geniculate nucleus.

    abstract::It has been suggested that lagged and non-lagged cells in the cat dorsal lateral geniculate nucleus (LGN) represent state-dependent response modes of the same class of LGN cells. In two separate experiments with single-unit recording in the LGN of anaesthetized and paralysed adult cats, a lagged and a nonlagged X-cell...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF02259147

    authors: Hartveit E

    更新日期:1992-01-01 00:00:00

  • Flexion reflex modulation during stepping in human spinal cord injury.

    abstract::The flexion reflex modulation pattern was investigated in nine people with a chronic spinal cord injury during stepping using body weight support on a treadmill and manual assistance by therapists. Body weight support was provided by an upper body harness and was adjusted for each subject to promote the best stepping ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1854-x

    authors: Knikou M,Angeli CA,Ferreira CK,Harkema SJ

    更新日期:2009-07-01 00:00:00

  • Electrophysiological characteristics of hippocampal complex-spike cells and theta cells.

    abstract::Stimulating electrodes were chronically implanted in the ventral hippocampal commissure and the entorhinal cortex or angular bundle of rats. Moveable metal microelectrodes which could be passed through the hippocampus were implanted. All hippocampal units were classified s complex-spike cells or theta cells on the bas...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238898

    authors: Fox SE,Ranck JB Jr

    更新日期:1981-01-01 00:00:00

  • Updating the programming of a precision grip is a function of recent history of available feedback.

    abstract::In a recent study (Whitwell et al. in Exp Brain Res 185:111-119, 2008), we showed that the visuomotor system is "cognitively impenetrable" to the extent that explicit predictive knowledge of the availability of visual feedback on an upcoming trial fails to optimize grasping. The results suggested that the effects of t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1737-1

    authors: Whitwell RL,Goodale MA

    更新日期:2009-04-01 00:00:00

  • Facilitatory effect on the motor cortex by electrical stimulation over the cerebellum in humans.

    abstract::Electrical stimulation over the cerebellum is known to transiently suppress the contralateral motor cortex in humans. However, projections from the cerebellar nuclei to the primary motor cortex are disynaptic excitatory pathways through the ventral thalamus. In the present investigation we studied facilitatory effects...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00221-004-1979-x

    authors: Iwata NK,Hanajima R,Furubayashi T,Terao Y,Uesugi H,Shiio Y,Enomoto H,Mochizuki H,Kanazawa I,Ugawa Y

    更新日期:2004-12-01 00:00:00

  • Understanding the contribution of binocular vision to the control of adaptive locomotion.

    abstract::Abstract. Although the contribution of binocular vision to reach-to-grasp movements has been extensively studied, it has been largely ignored in locomotion. The aim of these studies was to explore the role of binocular vision during the approach phase and step over the obstacle and the contribution of head movements t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-001-0948-x

    authors: Patla AE,Niechwiej E,Racco V,Goodale MA

    更新日期:2002-02-01 00:00:00

  • Spatial and temporal modulation of joint stiffness during multijoint movement.

    abstract::Joint stiffness measurements during small transient perturbations have suggested that stiffness during movement is different from that observed during posture. These observations are problematic for theories like the classical equilibrium point hypothesis, which suggest that desired trajectories during movement are en...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000598

    authors: Mah CD

    更新日期:2001-02-01 00:00:00

  • Visual signals contribute to the coding of gaze direction.

    abstract::Accurate information about gaze direction is required to direct the hand towards visual objects in the environment. In the present experiments, we tested whether retinal inputs affect the accuracy with which healthy subjects indicate their gaze direction with the unseen index finger after voluntary saccadic eye moveme...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-002-1029-5

    authors: Blouin J,Amade N,Vercher JL,Teasdale N,Gauthier GM

    更新日期:2002-06-01 00:00:00

  • In situ measurement of the innervation ratio of motor units in human muscles.

    abstract::Volume conduction measurements were carried out the brachial biceps, tibialis anterior and deltoid, in normal human subjects. Attenuation constant K and time constant tau of the muscle tissue transfer function were measured, and the average electrode uptake area calculated for the three muscles. The average number of ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238380

    authors: Gath I,Stålberg E

    更新日期:1981-01-01 00:00:00

  • Participation of interneurons in penicillin-induced epileptic discharges.

    abstract::Interneurons of rat motor cortex in vivo and of rat hippocampal slices were studied during penicillin-induced epileptic discharges. Synchronous with pyramidal cells, they showed transient depolarizations similar to paroxysmal depolarization shifts in pyramidal cells. The transient depolarizations were followed by hype...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00229848

    authors: Domann R,Uhlig S,Dorn T,Witte OW

    更新日期:1991-01-01 00:00:00

  • Idiosyncratic variations in eye-head coupling observed in the laboratory also manifest during spontaneous behavior in a natural setting.

    abstract::The tendency to generate head movements during saccades varies from person to person. Head movement tendencies can be measured as subjects fixate sequences of illuminated targets, but the extent to which such measures reflect eye-head coupling during more natural behaviors is unknown. We quantified head movement tende...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-008-1534-2

    authors: Thumser ZC,Oommen BS,Kofman IS,Stahl JS

    更新日期:2008-12-01 00:00:00

  • A reexamination of the size-weight illusion induced by visual size cues.

    abstract::The size-weight illusion induced by visually perceived sizes was reexamined to investigate whether this illusion is a sensory based or cognitive-based phenomenon. A computer-augmented environment was utilized to manipulate visual size information of target objects independently of their haptic information. Two physica...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0803-1

    authors: Kawai S,Henigman F,MacKenzie CL,Kuang AB,Faust PH

    更新日期:2007-05-01 00:00:00

  • Supraspinal facilitation of cutaneous polysynaptic EPSPs in cat medical gastrocnemius motoneurons.

    abstract::We examined the characteristics of postsynaptic potentials (PSPs) produced in antidromically-identified medical gastrocnemius (MG) alpha-motoneurons by electrical stimulation of low threshold (less than 3 x T) distal limb cutaneous afferents in the sural (SUR) nerve in adult cats anesthetized with alpha-chloralose, to...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00235772

    authors: Pinter MJ,Burke RE,O'Donovan MJ,Dum RP

    更新日期:1982-01-01 00:00:00

  • Sensory and response contributions to visual awareness in extinction.

    abstract::Brain-damaged patients may extinguish contralesional stimuli when ipsilesional stimuli are presented simultaneously. Most theories of extinction postulate that stimuli compete for pathologically limited attentional resources with a bias to process ipsilesional over contralesional stimuli. Implicit in this view is the ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-003-1823-8

    authors: Ricci R,Chatterjee A

    更新日期:2004-07-01 00:00:00

  • Effects of biomechanical and task constraints on the organization of movement in precision aiming.

    abstract::Nine participants performed a reciprocal precision aiming task under different experimental conditions. Due to the anisotropy of the work space, varying the direction of motion (from 0 degrees to 315 degrees in steps of 45 degrees ) allowed exploration of the effects of biomechanical constraints that were found to aff...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00221-004-1964-4

    authors: Fernandez L,Bootsma RJ

    更新日期:2004-12-01 00:00:00