Abstract:
:We examined opioid binding in fractions with disconnected nerve endings (secretosomes) which were prepared from porcine neurohypophyses by centrifugation in a discontinuous Percoll gradient. Specific (= displaceable) binding was observed with 3H-etorphine and with 3H-diprenorphine, two ligands with low selectivity for distinct opiate receptor subclasses. No displaceable binding was found with the prototypic mu- and delta-ligands 3H-dihydromorphine and 3H-(D-Ala, D-Leu) enkephalin. Displacement of 3H-diprenorphine binding was almost absent with the selective mu- and delta-ligands morphiceptin and ICI-174864. Partial displacement occurred with the selective kappa-ligand U-50488 and with dynorphin. Binding of 3H-etorphine was stereo-specific. 3H-diprenorphine binding was saturable with a KD between 2 and 4 nM. Maximum of opiate binding activity was detected in the fractions with accumulated secretosomes. By autoradiography specific 3H-diprenorphine binding is shown to be mainly associated with secretosomes. In imunocytochemical preparations an oxytocin antibody was immunoreactive in 85% of the secretosomes in the fraction with highest opiate binding. These fractions in radioimmunoassays exhibited the largest contents in oxytocin and low vasopressin levels. The data therefore suggest that in the porcine neurohypophysis opioid binding sites of the kappa-type occur in secretory endings presumably of the oxytocin type.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Falke N,Martin Rdoi
10.1007/BF00271856subject
Has Abstractpub_date
1988-01-01 00:00:00pages
145-54issue
1eissn
0014-4819issn
1432-1106journal_volume
70pub_type
杂志文章abstract::Previous investigations have revealed that perceived spatial frequency of gratings rises as contrast is lowered. In order to account for this finding it has been postulated that the spatial frequency which produces the maximum response from cortical neurones decreases with contrast. We have examined this hypothesis by...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236862
更新日期:1986-01-01 00:00:00
abstract::Aiming movements of the upper limbs can be classified either as discrete, or reciprocal, or cyclic. The control of these movements after a stroke can be affected. The aim of this experimental, cross-sectional study was to characterize the performance of these movements after the right and left hemisphere chronic strok...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05897-6
更新日期:2020-10-01 00:00:00
abstract::The blocking effect of triethyldodecylammoniumbromide (TEA-C12), applied locally to the sciatic nerve, was studied in 28 adult BDF1 mice. Clinical parameters, electrophysiological recordings of muscle action potentials evoked by stimulation at the sciatic notch, and morphological aspects are presented. Our results sho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248862
更新日期:1989-01-01 00:00:00
abstract::We ask whether a target's velocity is considered when planning a fast interceptive action. Human volunteers hit targets that could move at different velocities from across a tilted screen (the hand starting 40 cm away from the screen). We examined how the direction in which the hand initially moved depended on the tar...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1832-2
更新日期:2004-07-01 00:00:00
abstract::The intracortical arborizations of thalamocortical fibers arising from the ventroposterolateral (VPL) nucleus in the cat were studied following intra-axonal injections of horseradish peroxidase (HRP). The axons were impaled 1.5 to 3 mm below the surface of the cortex, identified electrophysiologically by stimulating t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236304
更新日期:1987-01-01 00:00:00
abstract::The developmental pattern of hippocampal mossy fiber (dentate granule cell axon) innervation to the pyramidal cell layer was examined with anterograde transport methods. Injection of 3H-leucine into the dentate gyrus on PN 1 resulted in labeling of the incipient stratum lucidum extending to, but not beyond, the CA3 re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248368
更新日期:1988-01-01 00:00:00
abstract::Everyday actions can be characterized by whether they are freely chosen or commanded by external stimuli, and whether they produce pleasant or unpleasant outcomes. To assess how these aspects of actions affect the sense of agency, we asked participants to perform freely selected or instructed key presses which could p...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5112-3
更新日期:2018-01-01 00:00:00
abstract::In the frog's isolated head preparations, spontaneous activity was recorded from the whole nerve of the left horizontal semicircular canal (HC) for 6 min before and 16 min after destruction of the right labyrinth by heating or administration of d-tubocurarine (0.5 microliter, 5.10(-6)M) into the perilymph of the right...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235790
更新日期:1982-01-01 00:00:00
abstract::Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain perception in humans, a large number of investigators apply noxious stimuli to the body of volunteers while sampling brain activity using different functional neuroimaging techniques. These responses have been shown to origin...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-010-2340-1
更新日期:2010-08-01 00:00:00
abstract::Memory for object-place configurations appears to be a common function of the hippocampus in the human and monkey brain. The nature of the spatial information which enters into these object-configural memories in the primate, and the location of the memories themselves, have remained obscure, however. In the rat, much...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s002210050562
更新日期:1998-11-01 00:00:00
abstract::After injection of S35-methionine into cervical and lumbar dorsal root ganglia in turtle, a primary afferent projection was demonstrated on to the cerebellum. Few, but consistent patches of silver grains were found within the granular layer suggesting mossy fiber terminations. The projection was mainly ipsilateral and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF01208609
更新日期:1982-01-01 00:00:00
abstract::Several types of continuous human movements comply with the so-called Two-Thirds Power Law (2/3-PL) stating that velocity (V) is a power function of the radius of curvature (R) of the endpoint trajectory. The origin of the 2/3-PL has been the object of much debate. An experiment investigated further this issue by comp...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4569-9
更新日期:2016-06-01 00:00:00
abstract::Evidence suggests that there are positive effects of exercise on learning and memory. Moreover, some studies have demonstrated that forced exercise plays the role of a stressor. This study was aimed at investigating the effects of different timing of exercise and exercise withdrawal on memory, and serum and hippocampa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4349-y
更新日期:2015-10-01 00:00:00
abstract::Voluntary movements are preceded by a slow electrical potential of the brain (Bereitschafts-potential, BP) or readiness potential. The BP is accompanied by a magnetic field shift of similar time characteristics (Bereitschaftsmagnetfeld, BM). The BM preceding volitional right foot or toe movements was recorded from ant...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237152
更新日期:1983-01-01 00:00:00
abstract::The objectives of this study were to determine whether changes in electromyographic (EMG) responses observed during prolonged intracortical microstimulation (ICMS) were due to local plasticity of the motor system or to global changes in the preparation. Local effects would be expressed as changes only along the activa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242909
更新日期:1996-02-01 00:00:00
abstract::The topography and receptive field (RF) organization of neurones in the trunk zone of the thalamic ventrobasal complex (VB) projecting to the homologous zone of the ipsilateral first somatosensory area (SI) were studied in the cat by performing experiments of retrograde neuronal tracing and microelectrode recording. P...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236234
更新日期:1984-01-01 00:00:00
abstract::Past studies of the kinematics of human prehension have shown that varying object size affects the maximum opening of the hand, while varying object distance affects the kinematic profile of the reaching limb. These data contributed to the formulation of a theory that the reaching and grasping components of human preh...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231054
更新日期:1991-01-01 00:00:00
abstract::If horizontal saccades or smooth-pursuit eye movements are made with the line-of-sight at different elevations, the three-dimensional (3D) angular rotation axis of the globe tilts by half the vertical eye eccentricity. This phenomenon is named "half-angle rule" and is a consequence of Listing's law. It was recently fo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050943
更新日期:1999-11-01 00:00:00
abstract::In this study, we investigated the neural basis of virtual time to contact (VTC) and the hypothesis that VTC provides predictive information for future postural instability. A novel approach to differentiate stable pre-falling and transition-to-instability stages within a single postural trial while a subject was perf...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1956-5
更新日期:2009-10-01 00:00:00
abstract::The gain of the vestibulo-ocular reflex (VOR) of intact pigmented rats was adaptively modified by training protocols that created a visual-vestibular conflict. For training, head restrained animals were oscillated on a turntable in front of an optokinetic pattern projected onto a cylindrical wall. The optokinetic patt...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230530
更新日期:1991-01-01 00:00:00
abstract::Eye-hand coordination is geometrically complex. To compute the location of a visual target relative to the hand, the brain must consider every anatomical link in the chain from retinas to fingertips. Here we focus on the first three links, studying how the brain handles information about the angles of the two eyes and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1523-4
更新日期:2003-09-01 00:00:00
abstract::The uptake of L-glutamate was studied in astrocytes cultured from different brain areas of newborn rats as well as in two different cultures of neurons obtained from mouse brain. Both astrocytes and neurons exhibited high-affinity glutamate uptake with Km values ranging from 34 microM to 82 microM. Vmax values for ast...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239385
更新日期:1982-01-01 00:00:00
abstract::This paper presents ILGM (the Infant Learning to Grasp Model), the first computational model of infant grasp learning that is constrained by the infant motor development literature. By grasp learning we mean learning how to make motor plans in response to sensory stimuli such that open-loop execution of the plan leads...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1914-1
更新日期:2004-10-01 00:00:00
abstract::The ventral medulla oblongata of rats was analyzed with a double-labelling immunofluorescence technique using guinea pig antibodies directed against serotonin (5-HT) and rabbit antisera directed against enkephalin (ENK). Numerous cells in the region of nucleus raphe obscurus, nucleus raphe pallidus and nucleus raphe m...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249904
更新日期:1989-01-01 00:00:00
abstract::Previous research has demonstrated that viewing one's hand can induce tactile response compatibility effects at the hands. Here, we investigated the question of whether vision of one's own hand is actually necessary. The Eriksen flanker task was combined with the rubber hand illusion in order to determine whether tact...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4129-0
更新日期:2015-02-01 00:00:00
abstract::Human walking dynamics are typically framed in the context of mechanics and energetics rather than in the context of neuromuscular control. Dynamic walking principles describe one helpful theoretical approach to characterize efficient human walking mechanics over many steps. These principles do not, however, address h...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3708-9
更新日期:2013-12-01 00:00:00
abstract::The subcommissural organ (SCO) is a brain gland secreting glycoproteins into the cerebrospinal fluid (CSF), where they aggregate forming the Reissner's fiber (RF). By the continuous addition of newly released glycoproteins, RF grows along the cerebral aqueduct, fourth ventricle, and central canal of the spinal cord. A...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050848
更新日期:1999-10-01 00:00:00
abstract::Auditory dysfunction, including hypersensitivity and tinnitus, is a common symptom of autism spectrum disorder (ASD). Prenatal exposure to the antiseizure medication valproic acid (VPA) significantly increases the risk of ASD in humans and similar exposure is utilized as an animal model of ASD in rodents. Animals expo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05982-w
更新日期:2020-11-16 00:00:00
abstract::The purpose of this study was to compare the asymmetric gait induced by unilateral spinal cord injury in chicks with asymmetric gaits of other bipeds and quadrupeds. After lateral hemisection of the left thoracic spinal cord, kinetic (ground reaction forces) and kinematic (distance and timing) data were recorded as ch...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050515
更新日期:1998-10-01 00:00:00
abstract::Postural reactions to disruptions of stance are rapid and automatic in both quadrupeds and bipeds. Current evidence suggests that these postural responses are generated by the central nervous system as patterns involving muscle synergies. This study attempted to test this hypothesis of a centrally generated postural m...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237411
更新日期:1986-01-01 00:00:00