Abstract:
:The ventral medulla oblongata of rats was analyzed with a double-labelling immunofluorescence technique using guinea pig antibodies directed against serotonin (5-HT) and rabbit antisera directed against enkephalin (ENK). Numerous cells in the region of nucleus raphe obscurus, nucleus raphe pallidus and nucleus raphe magnus showed immunostaining for either 5-HT or ENK. A substantial number of cells showed positive immunostaining for both 5-HT and ENK. 5-HT/ENK double-labelled cells were most frequently encountered in an area that extended from the rostral aspect of the inferior olivary nucleus to the pontomedullary border. This region corresponds anatomically to nucleus raphe magnus/nucleus paragigantocellularis. In addition, a number of the 5-HT/ENK-containing cells were retrogradely labelled with Fluoro-Gold dye that had been injected into the thoracic spinal cord several days prior to perfusion. Schematic drawings showing the anatomical distribution of 5-HT/ENK colocalization are provided.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Millhorn DE,Hökfelt T,Verhofstad AA,Terenius Ldoi
10.1007/BF00249904subject
Has Abstractpub_date
1989-01-01 00:00:00pages
536-42issue
3eissn
0014-4819issn
1432-1106journal_volume
75pub_type
杂志文章abstract::Intracellular recording techniques were used to test for cross-modality and topographic convergence among inputs to area 3a of cerebral cortex. Recordings were made within the projection area of group I afferent fibers of the deep radial nerve in barbiturate-anesthetized cats. Epsps were evoked in 90% of neurons (81/9...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236532
更新日期:1985-01-01 00:00:00
abstract::When walking with a hand-held object, grip force is coupled in an anticipatory manner to changes in inertial force resulting from the accelerations and decelerations of gait. However, it is not known how grip and inertial forces are organized at the onset of gait, and if the two forces are coupled in the early phases ...
journal_title:Experimental brain research
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doi:10.1007/s00221-008-1476-8
更新日期:2008-09-01 00:00:00
abstract::The objectives of this study were to determine whether changes in electromyographic (EMG) responses observed during prolonged intracortical microstimulation (ICMS) were due to local plasticity of the motor system or to global changes in the preparation. Local effects would be expressed as changes only along the activa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00242909
更新日期:1996-02-01 00:00:00
abstract::Pieces of the developing cerebellar anlage were prepared from 13-15 day old rat embryos and transplanted to the cerebellar region of 5-7 and 13-14 day old rat pups. Approximately two months later, sections showed most grafts to consist of both cerebellar cortex, with a typical trilaminar organization, and white matter...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237288
更新日期:1984-01-01 00:00:00
abstract::In this study, we investigated the effects of ginkgolides (Gins A, B, C and J), the main constituent of the non-flavone fraction of EGb 761, on hypoxic injury induced by potassium cyanide (KCN) in primary cortical neurons. The neurons were pretreated with or without ginkgolides for 24 h before incubation with KCN for ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0823-x
更新日期:2007-06-01 00:00:00
abstract::When searching for a target with eye movements, saccades are planned and initiated while the visual information is still being processed, so that subjects often make saccades away from the target and then have to make an additional return saccade. Presumably, the cost of the additional saccades is outweighed by the ad...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2032-x
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abstract::A contrast reversal (alternating phase) stimulus was used to study the responses of 150 retinal ganglion cells from 15 adult cats. Because the majority of the cells did not show perfect linear spatial summation, a ratio of the firing rates at two time periods was used to express the degree of nonlinearity. Y-cells sho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236782
更新日期:1979-03-09 00:00:00
abstract::Intracortical inhibition was investigated in normal human volunteers by paired-pulse transcranial magnetic stimulation, using a new, computer-assisted threshold-tracking method. Motor threshold was defined as the stimulus amplitude required to evoke a motor evoked potential of 0.2 mV (peak-to-peak) in abductor pollici...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-001-0988-2
更新日期:2002-03-01 00:00:00
abstract::Growing evidence suggests that blind subjects outperform the sighted on certain tactile discrimination tasks depending on cutaneous inputs. The purpose of this study was to compare the performance of blind (n = 14) and sighted (n = 15) subjects in a haptic angle discrimination task, depending on both cutaneous and pro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1327-7
更新日期:2008-06-01 00:00:00
abstract::In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050237
更新日期:1997-12-01 00:00:00
abstract::This longitudinal study, extending over 12 months, assessed the behavioural and biochemical effects of hippocampal sympathetic ingrowth (HSI) into the partially denervated hippocampus. Male Long-Evans rats received fimbria-fornix lesions (FIFO) or sham operations at 90 days of age. At the same time half of the rats fr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230648
更新日期:1995-01-01 00:00:00
abstract::The activity of single neurons within the hand area of the precentral motor cortex of primates was recorded during the performance of a maintained precision grip between the thumb and forefinger. The finger opposition forces were exerted against a strain gauge which allowed force changes to be studied under near isome...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239743
更新日期:1975-09-29 00:00:00
abstract::We employed binocular magnetic search coils to study the vestibulo-ocular reflex (VOR) and visually enhanced vestibulo-ocular reflex (VVOR) of 15 human subjects undergoing passive, whole-body rotations about a vertical (yaw) axis delivered as a series of pseudorandom transients and sinusoidal oscillations at frequenci...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005639
更新日期:1997-04-01 00:00:00
abstract::Affordance theory and behavioural dynamics have been used as theoretical constructs to explain how individuals interact with the environment in order to avoid obstacles. Features of obstacle distance and multiple obstacle avoidance have been discussed in unique studies, yet the interactions of these environmental feat...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4803-5
更新日期:2017-02-01 00:00:00
abstract::Intradermal injection of capsaicin results in sensitization of spinothalamic tract cells to brushing and pressure applied to the cutaneous receptive field in anesthetized monkeys. A significant increase in background activity also occurs immediately after capsaicin injection that lasts for at least 2 h. A 40-50% decre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005675
更新日期:1997-06-01 00:00:00
abstract::Recent results on the nature and limits of multisensory enhancement are inconsistent when stimuli are presented across spatial regions. We presented visual, tactile and visuotactile stimuli to participants in two speeded response tasks. Each unisensory stimulus was presented to either the left or right hemispace, and ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2515-9
更新日期:2011-09-01 00:00:00
abstract::The ability to make accurate reaching movements toward proprioceptively defined target locations was studied in seven normal subjects who were trained to reach to five different targets in a horizontal plane, with no vision of hand or target. The task consisted of moving a handle from a fixed origin to each target loc...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229793
更新日期:1993-01-01 00:00:00
abstract::Impaired plantar flexor muscle activation during push-off in late stance contributes importantly to reduced gait ability in adults with cerebral palsy (CP). Here we used low-intensity transcranial magnetic stimulation (TMS) to suppress soleus EMG activity during push-off as an estimate of corticospinal drive in CP adu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05520-3
更新日期:2019-06-01 00:00:00
abstract::Research in the vestibular field has revealed the existence of a central process, called 'velocity storage', that is activated by both visual and vestibular rotation cues and is modified by gravity, but whose functional relevance during natural motion has often been questioned. In this review, we explore spatial orien...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-011-2568-4
更新日期:2011-05-01 00:00:00
abstract::Eight right-handed subjects performed rhythmic isometric applications of torque in the directions of pronation and supination of the forearm, in single limb and bimanual conditions. Bimanual 'movements' were executed in either in-phase (homologous muscles simultaneously active) or anti-phase (non-homologous muscles ac...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00233046
更新日期:1995-01-01 00:00:00
abstract::Autologous segments of peroneal nerve were implanted into the medulla of adult rats to induce axonal regeneration of central neurons axotomised during the grafting procedure. Grafts were inserted in the midline--where respiratory axons decussate--or laterally, either in the nucleus tractus solitarius or in the nucleus...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228412
更新日期:1994-01-01 00:00:00
abstract::We investigated a double-label 2-DG protocol and method of analysis in which sequential injections of 3H- and 14C-2-DG were used to map brain metabolism during two distinct experimental treatments in the same animal. In initial studies, brain sections from rats given only 3H-2-DG or only 14C-2-DG were exposed on Ultro...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00270687
更新日期:1987-01-01 00:00:00
abstract::The present study assessed changes in perceived heaviness of weights lifted by the thumb, index, ring and little fingers during anaesthesia of the "lifting" digit. Subjects (n = 19) lifted weights solely by flexion of the distal joint of the digit, using a bilateral weight-matching paradigm. Changes in perceived heavi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050247
更新日期:1997-12-01 00:00:00
abstract::The neuronal responsiveness to three-dimensional (3D) motion in cat posteromedial lateral suprasylvian (PMLS) cortex was studied using a computer-controlled, stereoscopic 3D graphic display capable of reproducing the major visual cues for natural 3D motion, including motion disparity, size, texture, and shading change...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050509
更新日期:1998-09-01 00:00:00
abstract::Our perception of the vertical depends on allocentric information about the visual surrounds, egocentric information about the own body axis and gravicentric information about the pull of gravity. Previous work has documented that some individuals rely strongly on allocentric information, while others do not, and the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4526-z
更新日期:2016-04-01 00:00:00
abstract::It has previously been found that in fast point-to-point arm movements, proprioceptive feedback is centrally suppressed at the beginning of movement and is facilitated at a time that is correlated with temporal parameters of the planned movement. Here, we show that this correlation holds when subjects are explicitly i...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1967-2
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:The occurrence of postural and balance disorders is a frequent feature in advanced forms of Parkinson's disease (PD). However, the pathological substrate of these disturbances is poorly understood. METHODS:In the present work, we investigated the evolution of posturometric parameters [center of pressure (Co...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0202-z
更新日期:2006-04-01 00:00:00
abstract::Previous studies have found that affective states with high motivational intensity narrow attentional scope, whereas affective states with low motivational intensity broaden attentional scope. This conclusion, however, is based on fragmented evidence based on several separate studies. The present study tests this conc...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4014-x
更新日期:2014-10-01 00:00:00
abstract::This study exploited the alterations in pedal speed and joints kinematics elicited by changing crank length (CL) to test how altered task mechanics during cycling will modulate the muscle activation characteristics in human rectus femoris (RF), biceps femoris long head (BF), soleus (SOL) and tibialis anterior (TA). Ki...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1561-y
更新日期:2003-10-01 00:00:00
abstract::Interval timing deficiencies in Parkinson's disease (PD) patients have been a matter of debate. Here we test the possibility of PD heterogeneity as a source for this discrepancy. Temporal performance of PD patients and control subjects was assessed during two interval tapping tasks and during a categorization task of ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1097-7
更新日期:2008-01-01 00:00:00