Lesion-induced CA1 mossy fibers in the rat represent a neoinnervation.

Abstract:

:The developmental pattern of hippocampal mossy fiber (dentate granule cell axon) innervation to the pyramidal cell layer was examined with anterograde transport methods. Injection of 3H-leucine into the dentate gyrus on PN 1 resulted in labeling of the incipient stratum lucidum extending to, but not beyond, the CA3 region on PN 3 and 5. Since destruction of CA3 pyramidal cells on PN 5 results in aberrant mossy fiber innervation to CA1 pyramidal cells (Cook and Crutcher 1985), these results suggest that the presence of mossy fibers in CA1 of the rat represents a neoinnervation (perhaps representing a more primitive pattern of connectivity) and not the persistence of a transient developmental projection.

journal_name

Exp Brain Res

authors

Cook TM,Crutcher KA

doi

10.1007/BF00248368

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

433-6

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

70

pub_type

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