Abstract:
:Cultured rat hippocampal neurons with short processes were investigated using the whole cell voltage clamp under conditions appropriate for isolating Na+ currents. After incubation of the neuron culture for a period of 15-30 min in 1 mM sodium valproate, several parameters of the Na+ current were changed. The peak Na+ conductance gp, measured using hyperpolarizing prepulses, was reduced by valproate in a voltage-dependent manner. In the membrane voltage range from -30 to +20 mV, this reduction showed a linear dependence on voltage, increasing from about zero to approximately 30% of gp, the maximum peak Na+ conductance of the neuron. At the holding voltage of -70 mV, the inactivation parameter h infinity decreased from 0.88 in the control to 0.64 in the valproate solution. This reduction originated mainly from a 10 mV shift in the sigmoid relation between h infinity and membrane voltage along the voltage axis to hyperpolarizing potentials. The decay of the maximum peak Na+ current (inactivation) could be fitted by a biexponential function. Time constants of the fast and slow component at -20 mV decreased in valproate by about 50%. Valproate also retarded the recovery from inactivation, as determined at the holding voltage. The sigmoid recovery from inactivation could reasonably be described by an exponential function with time constant tau r and delay time delta t. Both tau r and delta t increased more than 200% in valproate. Our results indicate that valproate affected the Na+ current in hippocampal neurons in a way that contributed to a considerable depression of Na+ reactivation.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Van den Berg RJ,Kok P,Voskuyl RAdoi
10.1007/BF00228395subject
Has Abstractpub_date
1993-01-01 00:00:00pages
279-87issue
2eissn
0014-4819issn
1432-1106journal_volume
93pub_type
杂志文章abstract::In the metadata of the original publication of the article. ...
journal_title:Experimental brain research
pub_type: 杂志文章,已发布勘误
doi:10.1007/s00221-019-05476-4
更新日期:2019-02-01 00:00:00
abstract::We investigated how neurons in the different motor areas of the frontal lobe reflect the movement dynamics, and how their neuronal activity undergoes plastic changes when monkeys adapt to perturbing forces (they learn new dynamics). Here we describe the results obtained in the dorsal premotor area (PMd) and ventral pr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0074-2
更新日期:2006-01-01 00:00:00
abstract::Haptic guidance has been shown to have both facilitatory and interfering effects on motor learning. Interfering effects have been hypothesized to result from the particular dynamic environment, which supports a passive role of the learner, and they should be attenuated by fading guidance. Facilitatory effects, in part...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-3914-0
更新日期:2014-07-01 00:00:00
abstract::The aim of this study was to evaluate the hypothesis that an individual's preferred or usual walking speed, step length and cadence optimize the stability of head and pelvic accelerations in vertical (V), anterior-posterior (AP) and medio-lateral (ML) planes when walking. Acceleration patterns of the head and pelvis w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1094-x
更新日期:2008-01-01 00:00:00
abstract::Coordination is often observed as body parts moving together. However, when producing force with multiple fingers, the optimal coordination is not to produce similar forces with each finger, but rather for each finger to correct mistakes of other fingers. In this study, we aim to determine whether and how this skill d...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-5093-2
更新日期:2017-12-01 00:00:00
abstract::Stroke is one of the leading causes of mortality and morbidity in advanced countries of the world. Despite the fact that reactive oxygen and nitrogen species (ROS and RNS) are the by-products of normal metabolic processes and mediate important physiological processes, they can inflict damage to the cell if produced in...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-007-1050-9
更新日期:2007-09-01 00:00:00
abstract::We examined the synaptic connections between pairs of Bötzinger-complex, bulbospinal expiratory neurons in decerebrate rats. All were antidromically activated from the spinal cord at the C2-C3 border. Cross-correlation histograms of 18 ipsilateral pairs showed troughs on both sides of time zero (8) and to one side of ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050701
更新日期:1999-04-01 00:00:00
abstract::The development of the ability to integrate postural adjustments into the gait initiation process was investigated in children, using both kinematic and electromyographic (EMG) analysis. Subjects included children of 1 year of age (1-4 months' walking experience), 2-3 years of age (9-17 months' walking experience), 4-...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1044-6
更新日期:2002-06-01 00:00:00
abstract::Sensory experience during perinatal life and adulthood modifies physiological and anatomical characteristics of the central nervous system. So far, this phenomenon has been studied in situations of complete or partial sensory deprivation. We here report that increased sensory stimulation, during four days, of a number...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230256
更新日期:1989-01-01 00:00:00
abstract::Intradermal injection of capsaicin results in sensitization of spinothalamic tract cells to brushing and pressure applied to the cutaneous receptive field in anesthetized monkeys. A significant increase in background activity also occurs immediately after capsaicin injection that lasts for at least 2 h. A 40-50% decre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/pl00005675
更新日期:1997-06-01 00:00:00
abstract::This study investigated whether the execution of an accurate pointing response depends on a prior saccade orientation towards the target, independent of the vision of the limb. A comparison was made between the accuracy of sequential responses (in which the starting position of the hand is known and the eye centred on...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00228987
更新日期:1994-01-01 00:00:00
abstract::The insula is a region that integrates interoception and drug urges, but little is known about its role in behavioral addiction such as internet addiction. We investigated insula-based functional connectivity in participants with internet gaming disorder (IGD) and healthy controls (HC) using resting-state functional M...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4659-8
更新日期:2016-09-01 00:00:00
abstract::Empathy, i.e., the ability to perceive and share another person's affective state, is associated with activity in a complex neural network, including the anterior insula, the anterior and mid-cingulate cortex, and the lateral prefrontal cortex. Here, we were interested in the question how facial emotions influence the...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4731-4
更新日期:2016-11-01 00:00:00
abstract::In walking cats decerebrated at the premammillary level, single neurone activity of Purkinje cells (P-cells) with long corticofugal axons was recorded in the cerebellar vermis. The P-cells (N = 145) were identified as they showed spontaneous simple and complex spikes and also antidromic activation from Deiters' nucleu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238886
更新日期:1981-01-01 00:00:00
abstract::Trajectories of goal-directed movements are less curved for movements over a surface (constrained) than for movements in empty space (unconstrained). To study whether this difference arises from feeling the surface slip across the skin or having to control the movements in a third dimension, we manipulated the availab...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4030-x
更新日期:2014-11-01 00:00:00
abstract::The present review examines the experimental evidence supporting the existence of central mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the spinal cord of vertebrates. The first section covers work on the mode of operation and the synaptic mechanisms of presynaptic inhibition, in p...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s002210050933
更新日期:1999-11-01 00:00:00
abstract::It is well established that neuronal transmission from the entorhinal cortex through the dentate gyrus via the perforant path is dependent on behavioral state. To further study the modulation of neuronal transmission by behavioral state we employed the paired-pulse technique to study interneuronally-mediated inhibitio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249612
更新日期:1989-01-01 00:00:00
abstract::Developmental changes in the human brain coincide with and underlie changes in a wide range of motor and cognitive abilities. Neuroimaging studies have shown that musical training can result in structural and functional plasticity in the brains of musicians, and that this plasticity is greater for those who begin trai...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0619-z
更新日期:2007-01-01 00:00:00
abstract::An economical method of computing the source densities underlying human scalp-recorded event-related potentials (ERPs) is used to investigate the topography of "evaluation potentials" elicited when a subject assess the outcome of a goal-directed activity. No sign of a generative focus was observed in frontal locations...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235821
更新日期:1984-01-01 00:00:00
abstract::A lesion limited to the dorsal columns, at the level of L3-L4, was carried out in chronic cats. This operation produced a "partial axotomy" type of lesion on the ascending branches of Ia hind limb afferents. Two to six months after this operation, intracellular studies on L7-S1 motoneurons were carried out. Similar st...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00340482
更新日期:1986-01-01 00:00:00
abstract::We investigated the association between the degree of lesion overlap with the corticospinal tract and walking performance before and after 4-weeks of partial body weight support (PBWS) treadmill training in 18 individuals (ten male, eight female) with a mean age 59 +/- 13 years (mean +/- SD), range 32-74 years, who we...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1237-0
更新日期:2008-03-01 00:00:00
abstract::We investigated the capacities of human subjects to intercept moving targets in a two-dimensional (2D) space. Subjects were instructed to intercept moving targets on a computer screen using a cursor controlled by an articulated 2D manipulandum. A target was presented in 1 of 18 combinations of three acceleration types...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/pl00005769
更新日期:1997-10-01 00:00:00
abstract::The content of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) in motoneurons was studied in four motor pools supplying muscles in the rat hind limb subserving different types of motor activity. The motor pools were identified by retrograde labeling with horseradish peroxidase or fluorophore-conjugated...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227109
更新日期:1993-01-01 00:00:00
abstract::In order to determine whether neurones in the parvicellular reticular formation are in direct synaptic contact with motoneurones innervating facial muscles, a combined retrograde and anterograde transport study was carried out in the rat. Animals received injections of the retrograde tracer cholera toxin B conjugated ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227336
更新日期:1994-01-01 00:00:00
abstract::This study represents the first systematic comparison of the relative contributions of auditory and visual feedback to sequence production. Participants learned an isochronous melody that they performed on a keyboard and attempted to perform this sequence at a prescribed rate while auditory and visual feedback were ma...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3289-z
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to examine how adults processed common fractions with common numerators under two distinct conditions. Whereas participants were presented with only common fractions in a "simple" condition, a "complex" condition involved the random presentation of common fractions as well as decimal fraction...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2969-4
更新日期:2012-03-01 00:00:00
abstract::In this study, transcranial magnetic stimulation (TMS) of the primary motor hand area was used to test cortical excitability in Parkinson's disease (PD) patients. Motor evoked potentials (MEPs) to TMS were studied at rest by utilising distinct paired-pulse TMS protocols. Out of 29 untreated PD patients and 29 healthy ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100839
更新日期:2001-11-01 00:00:00
abstract::We tested the hypothesis that frontal eye field (FEF) visual activity integrates visual information with a template of a target by examining whether a target that is not present in a search display influences the target selection in FEF. Neural activity was recorded in FEF of macaque monkeys performing visual search f...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1461-1
更新日期:2003-08-01 00:00:00
abstract::Efficient daily navigation is underpinned by path integration, the mechanism by which we use self-movement information to update our position in space. This process is well understood in adulthood, but there has been relatively little study of path integration in childhood, leading to an underrepresentation in account...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3709-8
更新日期:2013-12-01 00:00:00
abstract::In anesthetized cats 251 cells within the cortical vestibular projection area, adjacent to the post-cruciate dimple, were analyzed as to their input characteristics employing extracellular recording techniques. The post cruciate dimple vestibular field, which is located in area 3a, has a high degree of convergence bet...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237688
更新日期:1975-01-01 00:00:00