Abstract：
:Recent animal studies have found neuronal expression of major histocompatibility complex (MHC) class I in the central nervous system (CNS). However, the developmental expression profiles of MHC class I in human CNS remain unclear. Here, we systemically evaluate the expression and subcellular localization of MHC class I molecules during human CNS development using immunohistochemistry and immunofluorescence. Between the age of 20-33 gestational weeks (GW), MHC class I expression was relatively absent in the cerebral cortex with the exception of a few neurons; however, expression increased rapidly in the cochlear nuclei and in the cerebellar cortical Purkinje cells while increasing slowly in the substantia nigra. Expression was also detected in some nuclei and nerve fibers of the brain stem including the ambiguus nucleus, the locus coeruleus and the solitary tract as early as 20 GW and persisted through 33 GW. These early-stage neural cells with MHC class I protein expression later developed neuronal morphology. 30-33 GW is an important period of MHC class I expression in neurons, and during this period, MHC class I molecules were found to be enriched not only in neuronal cell bodies and neurites but also in nerve fibers and in the surrounding stroma. No expression was detected in the adult brain with exception of the cerebrovascular endothelium. MHC class I molecules displayed greater postsynaptic colocalization in cerebellar Purkinje cells, in the lateral geniculate nucleus and in the cochlear nuclei. These results demonstrate diverse spatiotemporal expression patterns for MHC class I molecules in the prenatal human CNS and strongly support the notion that MHC class I molecules play important roles in both CNS development and plasticity.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Zhang A,Yu H,He Y,Shen Y,Zhang Y,Liu J,Fu B,Lv D,Miao F,Zhang Jdoi
10.1007/s00221-015-4345-2subject
Has Abstractpub_date
2015-09-01 00:00:00pages
2733-43issue
9eissn
0014-4819issn
1432-1106journal_volume
233pub_type
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pub_type： 杂志文章
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更新日期：2000-12-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章,评审
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更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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更新日期：2013-06-01 00:00:00
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更新日期：1981-01-01 00:00:00
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