Modulatory effects of high-frequency repetitive transcranial magnetic stimulation on the ipsilateral silent period.

Abstract:

:In healthy subjects, suprathreshold repetitive transcranial magnetic stimulation (rTMS) at frequencies >2 Hz prolongs the cortical silent period (CSP) over the course of the train. This progressive lengthening probably reflects temporal summation of the inhibitory interneurons in the stimulated primary motor cortex (M1). In this study, we tested whether high-frequency rTMS also modulates the ipsilateral silent period (ISP). In nine normal subjects, suprathreshold 10-pulse rTMS trains were delivered to the right M1 at frequencies of 3, 5, and 10 Hz during maximal isometric contraction of both first dorsal interosseous muscles. At 10 Hz, the second pulse of the train increased the area of the ISP; the other stimuli did not increase it further. During rTMS at 3 and 5 Hz, the ISP remained significantly unchanged. Control experiments showed that 10-Hz rTMS delivered at subthreshold intensity also increased the ISP. rTMS over the hand motor area did not facilitate ISPs in the biceps muscles. Finally, rTMS-induced ISP facilitation did not outlast the 10-Hz rTMS train. These findings suggest that rTMS at a frequency of 10 Hz potentiates the interhemispheric inhibitory mechanisms responsible for the ISP, partly through temporal summation. The distinct changes in the ISP and CSP suggest that rTMS facilitates intrahemispheric and interhemispheric inhibitory phenomena through separate neural mechanisms. The ISP facilitation induced by high-frequency rTMS is a novel, promising tool to investigate pathophysiological abnormal interhemispheric inhibitory transfer in various neurological diseases.

journal_name

Exp Brain Res

authors

Cincotta M,Giovannelli F,Borgheresi A,Balestrieri F,Zaccara G,Inghilleri M,Berardelli A

doi

10.1007/s00221-005-0296-3

keywords:

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

490-6

issue

4

eissn

0014-4819

issn

1432-1106

journal_volume

171

pub_type

杂志文章
  • A cognitive dual task affects gait variability in patients suffering from chronic low back pain.

    abstract::Chronic pain and gait variability in a dual-task situation are both associated with higher risk of falling. Executive functions regulate (dual-task) gait variability. A possible cause explaining why chronic pain increases risk of falling in an everyday dual-task situation might be that pain interferes with executive f...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-4039-1

    authors: Hamacher D,Hamacher D,Schega L

    更新日期:2014-11-01 00:00:00

  • Electrophysiological properties of rat pinealocytes: evidence for circadian and ultradian rhythms.

    abstract::Extracellular single-unit recordings were made during day- and night-time in the pineal gland of urethane-anesthetized adult male Sprague-Dawley rats. All cells exhibiting spontaneous electrical activity had firing frequencies from less than 1 Hz to about 100 Hz, and their discharge patterns were characterized as regu...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00235276

    authors: Reuss S,Vollrath L

    更新日期:1984-01-01 00:00:00

  • Updating the programming of a precision grip is a function of recent history of available feedback.

    abstract::In a recent study (Whitwell et al. in Exp Brain Res 185:111-119, 2008), we showed that the visuomotor system is "cognitively impenetrable" to the extent that explicit predictive knowledge of the availability of visual feedback on an upcoming trial fails to optimize grasping. The results suggested that the effects of t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1737-1

    authors: Whitwell RL,Goodale MA

    更新日期:2009-04-01 00:00:00

  • Perceptuo-motor learning rate declines by half from 20s to 70/80s.

    abstract::This study examined perception-action learning in younger adults in their 20s compared to older adults in their 70s and 80s. The goal was to provide, for the first time, quantitative estimates of perceptuo-motor learning rates for each age group and to reveal how these learning rates change between these age groups. W...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3349-4

    authors: Coats RO,Snapp-Childs W,Wilson AD,Bingham GP

    更新日期:2013-03-01 00:00:00

  • Importance of binocular vision in foot placement accuracy when stepping onto a floor-based target during gait initiation.

    abstract::This study investigated the importance of binocular vision to foot placement accuracy when stepping onto a floor-based target during gait initiation. Starting from stationary, participants placed alternate feet onto targets sequentially positioned along a straight travel path with the added constraint that the initial...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2910-x

    authors: Chapman GJ,Scally A,Buckley JG

    更新日期:2012-01-01 00:00:00

  • Vincristine-induced neuropathy in rat: electrophysiological and histological study.

    abstract::Peripheral sensory-motor neuropathy is one of the most frequent side effects of vincristine (VCR) administration, which often limits its usefulness in the treatment of a wide range of neoplastic diseases. The purpose of this work is to study VCR neurotoxicity in experimental animals from clinical, electrophysiological...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0499-2

    authors: Ja'afer FM,Hamdan FB,Mohammed FH

    更新日期:2006-08-01 00:00:00

  • Monosynaptic innervation of facial motoneurones by neurones of the parvicellular reticular formation.

    abstract::In order to determine whether neurones in the parvicellular reticular formation are in direct synaptic contact with motoneurones innervating facial muscles, a combined retrograde and anterograde transport study was carried out in the rat. Animals received injections of the retrograde tracer cholera toxin B conjugated ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227336

    authors: Mogoseanu D,Smith AD,Bolam JP

    更新日期:1994-01-01 00:00:00

  • Evolution of postural stability after subthalamic nucleus stimulation in Parkinson's disease: a combined clinical and posturometric study.

    abstract:OBJECTIVES:The occurrence of postural and balance disorders is a frequent feature in advanced forms of Parkinson's disease (PD). However, the pathological substrate of these disturbances is poorly understood. METHODS:In the present work, we investigated the evolution of posturometric parameters [center of pressure (Co...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-0202-z

    authors: Guehl D,Dehail P,de Sèze MP,Cuny E,Faux P,Tison F,Barat M,Bioulac B,Burbaud P

    更新日期:2006-04-01 00:00:00

  • Cyclophosphamide cystitis as a model of visceral pain in rats. A survey of hindbrain structures involved in visceroception and nociception using the expression of c-Fos and Krox-24 proteins.

    abstract::The evoked expression of the immediate early gene-encoded proteins c-Fos and Krox-24 was used to study activation of hindbrain neurons as a function of the development of cyclophosphamide (CP) cystitis in behaving rats. CP-injected animals received a single dose of 100 mg/kg i.p. under transient volatile anesthesia an...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227263

    authors: Bon K,Lantéri-Minet M,de Pommery J,Michiels JF,Menétrey D

    更新日期:1996-03-01 00:00:00

  • Changes in corticospinal excitability evoked by common peroneal nerve stimulation depend on stimulation frequency.

    abstract::The afferent volley generated during neuromuscular electrical stimulation (NMES) can increase the excitability of the human corticospinal (CS) pathway. This study was designed to determine the effect of different frequencies of NMES applied over the common peroneal nerve on changes in CS excitability for the tibialis ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2202-x

    authors: Mang CS,Lagerquist O,Collins DF

    更新日期:2010-05-01 00:00:00

  • Perception of affordances for standing on an inclined surface depends on height of center of mass.

    abstract::We investigated whether perception of affordances for standing on an inclined surface depended on the height of center of mass of the perceiver-actor. Participants adjusted the angle of inclination of a surface until they felt that it was just barely possible for them to stand on that surface. They performed this task...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-008-1492-8

    authors: Regia-Corte T,Wagman JB

    更新日期:2008-10-01 00:00:00

  • Non-motoneurons in the facial and motor trigeminal nuclei projecting to the cerebellar flocculus in the cat. A fluorescent double-labelling and WGA-HRP study.

    abstract::The cerebellar projection from the facial and motor trigeminal nuclei was studied in the cat by means of retrograde axonal transport of wheat germ agglutinin-horseradish peroxidase and fluorescent tracers. The feline facial nucleus was cytoarchitectonically subdivided into ventromedial, ventrolateral, lateral, dorsal,...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00247935

    authors: Røste GK

    更新日期:1989-01-01 00:00:00

  • Independent roles for the dorsal paraflocculus and vermal lobule VII of the cerebellum in visuomotor coordination.

    abstract::Two distinct areas of cerebellar cortex, vermal lobule VII and the dorsal paraflocculus (DPFl) receive visual input. To help understand the visuomotor functions of these two regions, we compared their afferent and efferent connections using the tracers wheatgerm agglutinin horseradish peroxidase (WGA-HRP) and biotinil...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0661-x

    authors: Kralj-Hans I,Baizer JS,Swales C,Glickstein M

    更新日期:2007-02-01 00:00:00

  • Goal-directed reaching: the allocentric coding of target location renders an offline mode of control.

    abstract::Reaching to a veridical target permits an egocentric spatial code (i.e., absolute limb and target position) to effect fast and effective online trajectory corrections supported via the visuomotor networks of the dorsal visual pathway. In contrast, a response entailing decoupled spatial relations between stimulus and r...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5205-7

    authors: Manzone J,Heath M

    更新日期:2018-04-01 00:00:00

  • Variation of magnitude and timing of wrist flexor stretch reflex across the full range of voluntary activation.

    abstract::This paper reports an investigation of the magnitude and timing of the stretch reflex over the full range of activation of flexor carpi radialis. While it is well established that the magnitude of the reflex increases with the level of muscle activation, there have been few studies of reflex magnitude above 50% of max...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-1848-7

    authors: Cathers I,O'Dwyer N,Neilson P

    更新日期:2004-08-01 00:00:00

  • Polymorphism in the µ-opioid receptor gene (OPRM1) modulates neural processing of physical pain, social rejection and error processing.

    abstract::Variations of the µ-opioid receptor gene OPRM1 have been shown to modulate pain perception with some evidence pointing towards a modulation of not only physical but also "psychological pain". In line with suggestions of a common neural network involved in the processing of physical pain and negative and distressing st...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-015-4322-9

    authors: Bonenberger M,Plener PL,Groschwitz RC,Grön G,Abler B

    更新日期:2015-09-01 00:00:00

  • Smooth eye movements evoked by electrical stimulation of the cat's superior colliculus.

    abstract::Head-fixed gaze shifts were evoked by electrical stimulation of the deeper layers of the cat superior colliculus (SC). After a short latency, saccades were triggered with kinematics similar to those of visually guided saccades. When electrical stimulation was maintained for more than 150-200 ms, postsaccadic smooth ey...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00230420

    authors: Missal M,Lefèvre P,Delinte A,Crommelinck M,Roucoux A

    更新日期:1996-01-01 00:00:00

  • Changes in the permeability of the blood-brain barrier following sodium dodecyl sulphate administration in the rat.

    abstract::The blood-brain barrier (BBB) arises from epithelial-like tight junctions that virtually cement adjoining capillary endothelium together in the brain microvasculature. Several experimental manipulations have been shown able to increase the permeability of brain capillaries, by altering endothelial cell membrane integr...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/pl00005725

    authors: Saija A,Princi P,Trombetta D,Lanza M,De Pasquale A

    更新日期:1997-07-01 00:00:00

  • Multi-frequency arm cycling reveals bilateral locomotor coupling to increase movement symmetry.

    abstract::Upright stance has allowed for substantial flexibility in how the upper limbs interact with each other: the arms can be coordinated in alternating, synchronous, or asymmetric patterns. While synchronization is thought to be the default mode of coordination during bimanual movement, there is little evidence for any bil...

    journal_title:Experimental brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00221-011-2687-y

    authors: Vasudevan EV,Zehr EP

    更新日期:2011-06-01 00:00:00

  • Coordination of spinal locomotor activity in the lamprey: long-distance coupling of spinal oscillators.

    abstract::The extent and strength of long-distance coupling between locomotor networks in the rostral and caudal spinal cord of larval lamprey were examined with in vitro brain/spinal cord preparations, in which spinal locomotor activity was initiated by chemical microstimulation in the brain, as well as with computer modeling....

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050719

    authors: McClellan AD,Hagevik A

    更新日期:1999-05-01 00:00:00

  • Morphological characteristics of cultured olfactory bulb cells.

    abstract::Cultured olfactory bulb cells from embryonic mice had ultrastructural characteristics similar to those of many cell types in the intact adult mouse olfactory bulb. Identified cultured cells included mitral/tufted cells, granule cells, short-axon cells, and fibrous and protoplasmic astrocytes. Cultured neurons were fou...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF02738402

    authors: Fracek SP Jr,Guo L,Schafer R

    更新日期:1994-01-01 00:00:00

  • Sensory reweighting with translational visual stimuli in young and elderly adults: the role of state-dependent noise.

    abstract::The properties of sensory reweighting for control of human upright stance have primarily been investigated through experimental techniques such as sinusoidal driving of postural sway. However, other forms of visual inputs that are commonly encountered, such as translation, may produce different adaptive responses. We ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0502-y

    authors: Jeka J,Allison L,Saffer M,Zhang Y,Carver S,Kiemel T

    更新日期:2006-10-01 00:00:00

  • Single joint perturbation during gait: neuronal control of movement trajectory.

    abstract::The aim of this study was to investigate the effect of single joint displacement on the pattern of leg muscle electromyographic (EMG) activity during locomotion. For the first time, unilateral rotational hip or knee joint displacements were applied by a driven orthotic device at three phases of swing during locomotion...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-004-1904-3

    authors: Dietz V,Colombo G,Müller R

    更新日期:2004-10-01 00:00:00

  • Learning and generalization of time production in humans: rules of transfer across modalities and interval durations.

    abstract::This article investigated both the ability of naive human subjects to learn interval production, as well as the properties of learning generalization across modalities and interval durations that varied systematically from the over-trained interval. Human subjects trained on a 450-, 650-, or 850-ms single-interval pro...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1895-1

    authors: Bartolo R,Merchant H

    更新日期:2009-07-01 00:00:00

  • Neuropeptide gene expression in brain is differentially regulated by midbrain dopamine neurons.

    abstract::In situ hybridization was used to study the expression of prepro-neuropeptide Y (NPY), preprosomatostatin (SOM), preprotachykinin (PPT) and preprocholecystokinin (CCK) mRNA in caudate-putamen and frontoparietal cortex of rat brain with unilateral lesion of midbrain dopamine neurons. Neurons expressing NPY and SOM mRNA...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227990

    authors: Lindefors N,Brené S,Herrera-Marschitz M,Persson H

    更新日期:1990-01-01 00:00:00

  • Timing of conditioned eyeblink responses is impaired in children with attention-deficit/hyperactivity disorder.

    abstract::Structural changes of the cerebellum have been reported in several psychiatric diseases like schizophrenia, autism and attention-deficit/hyperactivity disorder (ADHD). Beside behavioral deficits children with ADHD often show slight motor abnormalities. Cerebellar malfunction may contribute. The cerebellum is a structu...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2020-1

    authors: Frings M,Gaertner K,Buderath P,Gerwig M,Christiansen H,Schoch B,Gizewski ER,Hebebrand J,Timmann D

    更新日期:2010-03-01 00:00:00

  • On the link between action planning and motor imagery: a developmental study.

    abstract::We examined the link between action planning and motor imagery in 6- and 8-year-old children. Action planning efficiency was assessed with a bar transport task. Motor imagery and visual imagery abilities were measured using a hand mental rotation task and a number (i.e., non-body stimuli) mental rotation task, respect...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-013-3698-7

    authors: Toussaint L,Tahej PK,Thibaut JP,Possamai CA,Badets A

    更新日期:2013-11-01 00:00:00

  • Prenatal exposure to methylmercury alters locomotor activity of male but not female rats.

    abstract::In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050237

    authors: Rossi AD,Ahlbom E,Ogren SO,Nicotera P,Ceccatelli S

    更新日期:1997-12-01 00:00:00

  • Toxic effects of triethyldodecylammoniumbromide (TEA-C12) on myelinated nerve fibers and blood-nerve barrier in the mouse.

    abstract::The blocking effect of triethyldodecylammoniumbromide (TEA-C12), applied locally to the sciatic nerve, was studied in 28 adult BDF1 mice. Clinical parameters, electrophysiological recordings of muscle action potentials evoked by stimulation at the sciatic notch, and morphological aspects are presented. Our results sho...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00248862

    authors: Seitz RJ,Lipfert P,Willrich A,Himmelmann F

    更新日期:1989-01-01 00:00:00

  • Discharge properties of primary auditory fibres in Caiman crocodilus: comparisons and contrasts to the mammalian auditory nerve.

    abstract::Single fibre recordings were performed from the auditory nerve of the caiman, Caiman crocodilus. All neurones were spontaneously active (1-80 imp/s). Clicks evoked multiple peaks in the post stimulus time histogram spaced at 1/CF. At high intensities irregularities were observed. The latencies of the first peak observ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236735

    authors: Klinke R,Pause M

    更新日期:1980-01-01 00:00:00