Abstract：
:In order to determine the responses of paraventricular nucleus neurones following activation of central serotonergic pathways, single unit activity was recorded and responses following electrical stimulation of the midbrain dorsal raphe nucleus were examined. Excitation was recorded from approximately 50% of the cells, independent of whether they were antidromically identified as projecting to the median eminence or unidentified. Approximately 20% of cells were inhibited by the stimulation, the majority of these being unidentified. Parachlorophenylalanine-induced inhibition of serotonin synthesis reduced hypothalamic serotonin levels by 77% and caused a significant reduction in the proportion of cells excited by the stimulation, whereas the inhibitory responses were not affected. Intracerebroventricular administration of the serotonergic neurotoxin, 5,7-dihydroxytryptamine, which caused similar reductions in hypothalamic serotonin content (77%), reduced still further the proportion of excitatory responses and also reduced the proportion of cells inhibited by the stimulation. The data obtained suggest that serotonin acts as an excitatory neurotransmitter in the paraventricular nucleus; this is discussed particularly with respect to the regulation of the hypothalamo-hypophysial-adrenocortical axis. The loss of inhibitory responses in 5,7-dihydroxytryptamine treated, as opposed to the parachlorophenylalanine treated, animals suggests that the serotonergic fibers innervating the recorded cells may contain a cosecreted substance that may have important physiological actions in the control of neuronal activity in the region recorded.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Saphier D,Feldman Sdoi
10.1007/BF00228913subject
Has Abstractpub_date
1989-01-01 00:00:00pages
407-14issue
2eissn
0014-4819issn
1432-1106journal_volume
78pub_type
杂志文章abstract：:Peripheral sensory-motor neuropathy is one of the most frequent side effects of vincristine (VCR) administration, which often limits its usefulness in the treatment of a wide range of neoplastic diseases. The purpose of this work is to study VCR neurotoxicity in experimental animals from clinical, electrophysiological...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0499-2
更新日期：2006-08-01 00:00:00
abstract：:Single unit activity was recorded from tuberoinfundibular neurones in urethane-anaesthetized pro-oestrous rats. Responses following single shock (0.2 Hz) stimulation of the preoptic area/anterior hypothalamus (PO/AH) or nucleus accumbens (ACB) were recorded and computed for 137 single units. More cells were shown, by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236546
更新日期：1985-01-01 00:00:00
abstract：:We report the connections of cerebellar cortical lobule HVI in the rabbit. We have studied the anterograde and retrograde transport of wheatgerm-agglutinated horseradish peroxidase (WGA-HRP) following its injection into HVI to reveal efferent and afferent connections. All of the cases showed strong anterograde transpo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237024
更新日期：1985-01-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) causes the corticospinal system to become refractory to subsequent stimuli for up to 200 ms. We examined the phenomenon of paired pulse inhibition with TMS under conditions of rest, ongoing voluntary activation (isometric force generation), and at variable delays following activ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228638
更新日期：1996-04-01 00:00:00
abstract：:Normally, gamma motoneurones innervate only the intrafusal fibres of muscle spindles. This is a report of sprouting of gamma motoneurones to innervate extrafusal muscle fibres following partial denervation of the soleus muscle of kittens. In eight newborn animals, the L7 ventral root was cut on one side under anaesthe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227250
更新日期：1992-01-01 00:00:00
abstract：:This investigation was designed to study the effects of post-activation depression in different spinal pathways fed by group I afferents available to investigation in human subjects. It was precipitated by a recent investigation in the cat showing that-contrary to the general assumption-post-activation depression is n...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2360-4
更新日期：2005-10-01 00:00:00
abstract：:Saccular and utricular organs are essential for postural stability and gaze control. Although saccular and utricular inputs are known to terminate on vestibular neurons, few previous studies have precisely elucidated the origin of these inputs. We investigated the saccular and utricular inputs to single vestibular neu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900312
更新日期：2000-04-01 00:00:00
abstract：:This study compared and contrasted the manifestation of neuropathic pain behaviors in several strains of rats. These included ACI, Brown-Norway, Fischer 344, Lewis, Long-Evans, Sprague-Dawley, and Wistar-Furth, all obtained from Harlan Sprague-Dawley Inc. Comparison was also made between two substrains of Sprague-Dawl...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050886
更新日期：1999-11-01 00:00:00
abstract：:The properties of sensory reweighting for control of human upright stance have primarily been investigated through experimental techniques such as sinusoidal driving of postural sway. However, other forms of visual inputs that are commonly encountered, such as translation, may produce different adaptive responses. We ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0502-y
更新日期：2006-10-01 00:00:00
abstract：:A green button may be the target of a movement, or it may instruct the opening of an adjacent door. In the first case, its spatial configuration serves to guide the hand, whereas in the second case its colour allows a decision between alternative courses of action. This study contrasts these two categories of visuomot...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100877
更新日期：2001-12-01 00:00:00
abstract：:The latencies of visually-evoked responses from X- and Y-type neurons of the cat's dorsal lateral geniculate nucleus were measured in a manner that takes account of the inherent variability of discharge in these cells. Latencies measured in this way vary from trial to trial in one cell (and also between cells) by tens...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235998
更新日期：1987-01-01 00:00:00
abstract：:Encoding of visual target location in extrapersonal space requires convergence of at least three types of information: retinal signals, information about orbital eye positions, and the position of the head on the body. Since the position of gaze is the sum of the head position and the eye position, inaccuracy of spati...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00241543
更新日期：1994-01-01 00:00:00
abstract：:Movements of the dominant and nondominant hand have been claimed to differ with respect to how they take intersegmental dynamics into account. Consistent with this claim, movements of the dominant hand are hypothesized to better exploit the intrinsic limb dynamics, whereas movements of the nondominant hand are control...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0747-5
更新日期：2007-04-01 00:00:00
abstract：:In recordings from two awake, behaving macaque monkeys we found that neurons in the crown of the prelunate gyrus differed in their responsiveness to simple visual stimuli. Neurons in the posterior part of the gyrus (area V4) responded strongly to stationary or moving bars, while neurons in the anterior part (area V4A)...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1112-y
更新日期：2002-07-01 00:00:00
abstract：:Primary somatosensory cortex (S1) is known to rapidly adapt to task demands and to intermodal information (e.g. from vision). Here, we show that also intramodal information (i.e. posture) can affect tactile attentional selection processes and the intermodal effects of vision on those processes at S1 stages of processi...
journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00221-012-3171-z
更新日期：2012-09-01 00:00:00
abstract：:The present study was carried out to determine the effects of central nervous free fatty acids, lysophospholipids, or platelet activating factor (PAF), in a mouse facial carrageenan injection model of orofacial pain. Mice that received intracerebroventricular (I.C.V.) injection of arachidonic acid or oleic acid showed...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0672-7
更新日期：2006-10-01 00:00:00
abstract：:The relations among spatial memory, Stroop-like colour-word subtests, and errors on antisaccade and memory-guided saccadic eye-movement trials for older and younger adults were tested. Two types of errors in the antisaccade task were identified: short latency prosaccade errors that were immediately corrected and longe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2921-7
更新日期：2012-01-01 00:00:00
abstract：:Deep brain stimulation of the subthalamic nucleus (STN DBS) significantly improves clinical motor symptoms, as well as intensive aspects of movement like velocity and amplitude in patients with Parkinson's disease (PD). However, the effects of bilateral STN DBS on integrative and coordinative aspects of motor control ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5197-3
更新日期：2018-04-01 00:00:00
abstract：:Precise left-hand movements take longer than right-hand movements (for right-handers). To quantify how left-hand movements are affected by task difficulty and phase of movement control, we manipulated the difficulty of repetitive speeded aiming movements while participants used the left or right hand. We observed left...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3110-z
更新日期：2012-07-01 00:00:00
abstract：:We compared pursuit responses to 2D target motion in three separate conditions: predictable, randomised and randomised with timing cues. The target moved on a continuous quadrilateral path in which right-angle direction changes allowed anticipatory eye acceleration and deceleration in orthogonal axes to be assessed. R...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4164-x
更新日期：2015-03-01 00:00:00
abstract：:Single unit activity was recorded in the striate cortex of vision-deprived cats aged between 3 and 8 weeks. Contrast sensitivity or response measurements made using moving sinusoidal gratings were used to construct spatial frequency tuning curves. At 3 weeks sensitivity, selectivity (assessed both as the narrowness of...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235273
更新日期：1984-01-01 00:00:00
abstract：:To investigate the role of gravitational cues in the learning of a dynamic balancing task, we placed blindfolded subjects in a device programmed with inverted pendulum dynamics about the yaw axis. Subjects used a joystick to try and maintain a stable orientation at the direction of balance during 20 100 s-long trials....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5216-4
更新日期：2018-05-01 00:00:00
abstract：:Heparin affin regulatory peptide (HARP), also known as pleiotrophin or heparin-binding growth-associated molecule, is a developmentally regulated extracellular matrix protein that induces cell proliferation and promotes neurite outgrowth in vitro as well as pre- and postsynaptic developmental differentiation in vivo. ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000536
更新日期：2000-12-01 00:00:00
abstract：:During fast, saccadic eye movements visual perception is suppressed. This saccadic suppression prevents erroneous and distracting motion percepts resulting from saccade induced retinal slip. Although saccadic suppression occurs over a substantial time interval around the saccade, there is no "perceptual gap" during sa...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-0876-5
更新日期：2007-07-01 00:00:00
abstract：:In this work a statistical study is made of the final outcome of the quantification of the nerve cell labelling in the adult, after prenatal injection of tritiated thymidine. This outcome is presented in the form of histograms which are the superposition of elementary Poisson distributions. A theoretical model, based...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235410
更新日期：1975-01-01 00:00:00
abstract：:We used a virtual reality setup to let participants grasp discs, which differed in luminance, chromaticity and size. Current theories on perception and action propose a division of labor in the brain into a color proficient perception pathway and a less color-capable action pathway. In this study, we addressed the que...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1841-2
更新日期：2009-07-01 00:00:00
abstract：:The neuronal responsiveness to three-dimensional (3D) motion in cat posteromedial lateral suprasylvian (PMLS) cortex was studied using a computer-controlled, stereoscopic 3D graphic display capable of reproducing the major visual cues for natural 3D motion, including motion disparity, size, texture, and shading change...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050509
更新日期：1998-09-01 00:00:00
abstract：:(1) The responses of CA1 pyramidal cells to short glutamate pulses (10-50 ms) delivered at sensitive spots in the apical dendrites have been analysed by intracellular recording. (2) The glutamate pulses elicited stable depolarizing responses in a dose- and frequency-dependent manner. (3) When a single action potential...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228178
更新日期：1992-01-01 00:00:00
abstract：:1. Individual neurons were recorded extracellularly in the precentral forelimb area of two monkeys trained to perform rapid, large amplitude flexion and extension movements of the contralateral forearm in response to auditory signals. Electromyographic (EMG) activity in the biceps/triceps muscles was recorded separate...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228859
更新日期：1990-01-01 00:00:00
abstract：:In three monkeys made hemianopic by unilateral striate cortical ablation, in one normal monkey and in a human hemianope (GY), we measured reaction times to chromatic targets presented in the normal hemifield as a function of prior chromatic primes in the blind field. The first of our three tasks showed an unspecific p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1521-6
更新日期：2003-09-01 00:00:00
