Abstract:
:The relationship between neuronal calcium binding protein content (calbindin D28K: CaBP and parvalbumin: PV) and vulnerability to ischemia was studied in different regions of the rat brain using the four vessel occlusion model of complete forebrain ischemia. The areas studied, i.e. the hippocampal formation, neocortex, neostriatum and reticular thalamic nucleus (RTN), show a characteristic pattern of CaBP and PV distribution, and are involved in ischemic damage to different degrees. In the hippocampal formation CaBP is present in dentate granule cells and in a subpopulation of the CA1 pyramidal cells, the latter being the most and the former the least vulnerable to ischemia. Non-pyramidal cells containing CaBP in these regions survive ischemia, whereas PV-containing non-pyramidal cells in the CA1 region are occasionally lost. Hilar somatostatin-containing cells and CA3 pyramidal cells contain neither PV nor CaBP. Nevertheless, the latter are resistant to ischemia and the former is the first population of cells that undergoes degeneration. Supragranular pyramidal neurons containing CaBP are the most vulnerable cell group in the sensory neocortex. In the RTN the degenerating neurons contain both PV and CaBP. In the neostriatum, ischemic damage involves both CaBP-positive and negative medium spiny neurons, although the degeneration always starts in the dorsolateral neostriatum containing relatively few CaBP-positive cells. The giant cholinergic interneurons of the striatum contain neither CaBP nor PV, and they are the most resistant cell type in this area. These examples suggest the lack of a consistent and systematic relationship between neuronal CaBP or PV content and ischemic vulnerability. It appears that some populations of cells containing CaBP or PV are more predisposed to ischemic cell death than neurons lacking these proteins. These neurons may express high levels of calcium binding proteins because their normal activity may involve a high rate of calcium uptake and/or intraneuronal release.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Freund TF,Buzsáki G,Leon A,Baimbridge KG,Somogyi Pdoi
10.1007/BF00232193subject
Has Abstractpub_date
1990-01-01 00:00:00pages
55-66issue
1eissn
0014-4819issn
1432-1106journal_volume
83pub_type
杂志文章abstract::In four normal human subjects we measured eye movements during full-field optokinetic stimulation (10-220 deg/s) and determined the relationship among retinal-slip velocity (drum velocity minus slow-phase eye velocity), the slow-phase velocity of optokinetic nystagmus (OKN) and the initial value of the slow-phase velo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230099
更新日期:1990-01-01 00:00:00
abstract::Realistic appearance and complexity in the visual field are known to affect the strength of vection (visually induced self-motion perception). Although surface properties of materials are, therefore, expected to be visual features that influence vection, to date, the results have been mixed. Here, we used computer gra...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05620-0
更新日期:2019-10-01 00:00:00
abstract::Lengthening and shortening contractions are the fundamental patterns of muscle activation underlying various movements. It is still unknown whether or not there is a muscle-specific difference in such a fundamental pattern of muscle activation. The purpose of this study was, therefore, to investigate whether or not th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0743-9
更新日期:2007-04-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) was intermittently suppressed by fixating a head-fixed target (light on: 9 s; darkness: 2 s) during whole-body (60-100 deg/s peak; 0.01-0.17 Hz) sinusoidal and triangular oscillation about the vertical axis for about 2 min. Eye movements associated with intervals of darkness at differ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00261343
更新日期:1985-01-01 00:00:00
abstract::Excess thyroid hormone at an early stage of development produces marked neurochemical and morphological alterations in the rat hippocampal formation. In order to better understand the functional significance of these changes, we tested adult rats treated neonatally with triiodothyronine (T3), and their control litter ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231740
更新日期:1991-01-01 00:00:00
abstract::This study employed neurophysiological methods to relate the condition of the corticospinal system with the voluntary control of lower-limb muscles in persons with motor-incomplete spinal cord injury. It consisted of two phases. In a group of ten healthy subjects, single and paired transcranial magnetic stimulation (T...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2190-9
更新日期:2005-06-01 00:00:00
abstract::It is a conservative and reasonable suggestion that implicit functioning, as in blindsight, is simply a weakened, degraded form of normal functioning, especially as the parameters of vision in blindsight are themselves weakened--e.g., acuity is reduced, detection thresholds are raised, chromatic discrimination is coar...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-008-1388-7
更新日期:2009-01-01 00:00:00
abstract::Previous research has demonstrated that negative affect influences attentional processes. Here, we investigate whether pre-experimental negative affect predicts a hypervigilant neural response as indicated by increased event-related potential amplitudes in response to neutral and positive visual stimuli. In our study,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4544-x
更新日期:2016-06-01 00:00:00
abstract::Supervised learning of different postural tasks in patients with lesions of the motor cortex or pyramidal system (poststroke hemiparesis: 20 patients), nigro-striatal system (Parkinson's disease: 33 patients) and cerebellum (spinocerebellar ataxia: 37 patients) was studied. A control group consisted of 13 healthy subj...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-005-0096-9
更新日期:2006-01-01 00:00:00
abstract::We have studied the ultrastructural features of sensory nerve fibers in the ciliary body and the iris and their parent trigeminal ganglion cells, using intra-axonally transported horseradish peroxidase as a tracer. Unmyelinated nerve fibers of ipsilateral trigeminal origin were found in stroma of both the ciliary body...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235287
更新日期:1984-01-01 00:00:00
abstract::The cerebellum is recognised to bilaterally modulate sensorimotor function and has recently been shown to play a role in swallowing. Unilateral cerebellar repetitive trans-cranial magnetic stimulation (rTMS) excites corticobulbar motor pathways to the pharynx but the effects of bilateral versus unilateral cerebellar r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05787-x
更新日期:2020-08-01 00:00:00
abstract::Research on joint attention has addressed both the effects of gaze following and the ability to share representations. It is largely unknown, however, whether sharing attention also affects the perceptual processing of jointly attended objects. This study tested whether attending to stimuli with another person from op...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2625-z
更新日期:2011-06-01 00:00:00
abstract::Prior research has concluded that the correlations of isometric finger forces represent the extent to which the fingers are controlled as a single unit. If this is the case, finger force correlations should be consistent with estimates of the controlled (dynamical) degrees of freedom in finger forces. The present stud...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3280-8
更新日期:2012-12-01 00:00:00
abstract::The present study investigated age-related changes in the attentional demands associated with interlimb coordination involving upper and lower limbs performed at three different movement frequencies. Younger and older adults performed rhythmical, 180° out-of-phase flexion-extension movements of the knee and elbow with...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3511-7
更新日期:2013-06-01 00:00:00
abstract::When a target moves to a new location during a rapid aiming movement, the hand follows it, even when the participant intends not to. Pisella et al. (Nat Neurosci 3:729-736, 2000) claim that the posterior parietal cortex, in the dorsal visual stream, is responsible for this 'automatic pilot'. Here we study the limits o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-0935-y
更新日期:2007-08-01 00:00:00
abstract::Morphometric changes have been studied at the mouse neuromuscular junction (NMJ) as a function of the frequency of stimulation. In vivo stimulation was made at either 10, 25, 50 or 100 Hz. No significant change in the area of NMJ profiles is observed after stimulation. This indicates that stimulation does not change t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237590
更新日期:1986-01-01 00:00:00
abstract::We investigated the effect of different spatial and temporal parameters on the saccadic reaction times (SRTs) of the antisaccades and on the frequency and the SRTs of erratic prosaccades in five adult human subjects. The subjects were instructed to aim their saccades to the side opposite to where a visual go-stimulus ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/pl00005749
更新日期:1997-09-01 00:00:00
abstract::We investigated in sheep the effects of stimulation of the thick afferent fibers running through the lingual nerve (LN) upon the activity of some of the muscles and medullary interneurons or motoneurons which are active during swallowing. Using electromyography (EMG), and extra- and intracellular neuronal recording, w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000361
更新日期:2000-06-01 00:00:00
abstract::Directional preferences have previously been demonstrated during horizontal arm movements. These preferences were characterized by a tendency to exploit interaction torques for movement production at the shoulder or elbow, indicating that the preferred directions depend on biomechanical, and not on visual perception-b...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-013-3766-z
更新日期:2014-02-01 00:00:00
abstract::The present experiments were designed to investigate the neuronal mechanisms, at the level of the primary somatosensory cortex, which underlie the observation that somatosensory cortical potentials evoked by air puff stimuli directed at the forearm are decreased, in a nonspecific and widespread manner, during voluntar...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231455
更新日期:1991-01-01 00:00:00
abstract::Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236214
更新日期:1987-01-01 00:00:00
abstract::The role of kinaesthetic afferences in controlling coupling of voluntary oscillation of the hand and foot, both in-phase and anti-phase, was investigated by modifying the mechanical properties of one of the two segments (the hand) with applied inertial or elastic loads. Loads consisted of a lead disk, rotating coaxial...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210100762
更新日期:2001-07-01 00:00:00
abstract::Functional magnetic resonance imaging was used to explore the neural correlates of semantic judgments to Chinese characters. Adult participants were asked to indicate if character pairs were related in meaning that were arranged in a continuous variable according to association strength. This parametric manipulation a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1942-y
更新日期:2009-10-01 00:00:00
abstract::The distributions of the kainate/DL-alpha-amino-3-hydroxy-5-methylisoxazolepropionic acid (KA/ AMPA) receptors GluR1 and calcium-activated neutral protease II (calpain II) in the hippocampus of normal and kainate-lesioned rats were studied by immunocytochemistry. There was a reduction in GluR1 immunoreactivity and a s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02454147
更新日期:1997-01-01 00:00:00
abstract::Trajectories of goal-directed movements are less curved for movements over a surface (constrained) than for movements in empty space (unconstrained). To study whether this difference arises from feeling the surface slip across the skin or having to control the movements in a third dimension, we manipulated the availab...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4030-x
更新日期:2014-11-01 00:00:00
abstract::The aim of this study was to analyse the functional impairments caused by chronic median nerve compression at the wrist on hand sensation and manual skill. Hand function was assessed in 11 patients (8 women and 3 men) with severe carpal tunnel syndrome (CTS) and compared with that of an age- and sex-matched control gr...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050817
更新日期:1999-09-01 00:00:00
abstract::Quantitative analysis of dendritic orientation in rapid Golgi sections of the lateral geniculate nucleus of Old World monkeys was performed with the help of a computer-microscope and a tree-analysing program. The orientation of intermediate and terminal dendritic segments of parvocellular and magnocellular multipolar ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236293
更新日期:1984-01-01 00:00:00
abstract::The purpose of this study was to establish whether visual motion parallax participates in the control of postural sway. Body sway was measured in ten normal subjects by photoelectric recordings of head movements and by force-plate posturography. Subjects viewed a visual display ("background"), which briefly moved (2 s...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02450322
更新日期:1997-02-01 00:00:00
abstract::Primary gaze fixation is never perfectly stable but can be interrupted by involuntary, conjugate saccadic intrusions (SI). SI have a high prevalence in the normal population and are characterised by a horizontal fast eye movement away from the desired eye position, followed, after a variable duration, by a return sacc...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2209-2
更新日期:2005-07-01 00:00:00
abstract::The overlap of dominant tremor frequencies and similarly amplified tremor observed for Parkinson's disease (PD) and essential tremor (ET) means differentiating between these pathologies is often difficult. As tremor exhibits non-linear properties, employing both linear and non-linear analyses may help distinguish betw...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-017-4924-5
更新日期:2017-06-01 00:00:00