Abstract：
:Excess thyroid hormone at an early stage of development produces marked neurochemical and morphological alterations in the rat hippocampal formation. In order to better understand the functional significance of these changes, we tested adult rats treated neonatally with triiodothyronine (T3), and their control litter mates, in a spatial learning task and for the induction of long-term potentiation (LTP) in the dentate gyrus (DG) of the hippocampal formation. The T3-treated rats were significantly impaired in their performance on the spatial task in comparison to their matched controls. Similarly, the efficacy of LTP induction was significantly attenuated in the T3-treated animals. Further, a significant correlation was obtained between LTP induction and performance on the spatial learning task. Thus, a brief neonatal excess of thyroid hormone produces impairments in spatial learning along with decreases in LTP, long held as a model of learning and memory. This relationship provides a unique opportunity to study associations between behavioral, physiological, pharmacological and morphological processes intimately associated with the hippocampal formation.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Pavlides C,Westlind-Danielsson AI,Nyborg H,McEwen BSdoi
10.1007/BF00231740subject
Has Abstractpub_date
1991-01-01 00:00:00pages
559-64issue
3eissn
0014-4819issn
1432-1106journal_volume
85pub_type
杂志文章abstract：:Cell responses to complex visual patterns such as compositions of broad-band (non-monochromatic) colour areas are presented. Patterns were scanned over the receptive field, and cell response at each point was recorded. "Response patterns" were constructed which display the cell transform of the stimulus pattern. Parvo...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239571
更新日期：1982-01-01 00:00:00
abstract：:The current study examined the EEG of young, old and old declined adults performing a visual paired associate task. In order to examine the effects of encoding context and stimulus repetition, target pairs were presented on either detailed or white backgrounds and were repeatedly presented during both early and late p...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2966-7
更新日期：2012-02-01 00:00:00
abstract：:Functional reorganization in a musician's brain has long been considered strong evidence of experience-dependent neuroplasticity. Highly coordinated bimanual movements require abundant communication between bilateral hemispheres. Interhemispheric inhibition (IHI) is the communication between bilateral primary motor co...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05951-3
更新日期：2020-12-01 00:00:00
abstract：:Transcranial magnetic stimulation (TMS) causes the corticospinal system to become refractory to subsequent stimuli for up to 200 ms. We examined the phenomenon of paired pulse inhibition with TMS under conditions of rest, ongoing voluntary activation (isometric force generation), and at variable delays following activ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228638
更新日期：1996-04-01 00:00:00
abstract：:Albinism affects the anatomy and physiology of the visual system in mammals. Behavioural, anatomical and in vivo electrophysiological investigations revealed that the optokinetic reflex is abnormal and retinal slip neurons in the nucleus of the optic tract and the dorsal terminal nucleus of the accessory optic system ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1722-8
更新日期：2009-12-01 00:00:00
abstract：:Motor learning results from repeated exposure to the same movement and allows a mover to increase movement optimality. Typically, this has only been considered in single-step movements. In sequential movements, an initial reach movement is tailored to the demands of the onward movement. However, the exact role of moto...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3728-5
更新日期：2014-01-01 00:00:00
abstract：:The aim of this research was to analyse the development of postural reactions to approaching (AOF) and receding (ROF) ground rectilinear optical flows. Optical flows were shaped by a pattern of circular spots of light projected on the ground surface by a texture flow generator. The geometrical structure of the project...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1930-1
更新日期：2004-11-01 00:00:00
abstract：:The contextual interference hypothesis proposes that when learning multiple skills, massing practice leads to better within-day acquisition, whereas random practice leads to better retention and transfer. In this experiment, we examined the effect of practice pattern on the learning, consolidation (retention), and tra...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2311-6
更新日期：2010-07-01 00:00:00
abstract：:Serotonin reveals ineffective (subthreshold) pathways from the C2 lateral funiculus to ipsilateral phrenic motoneurons in spinalized rats. The objective of the present study was to investigate serotonergic modulation of crossed-spinal pathways to contralateral phrenic motoneurons. Rats (n = 10) were anesthetized (uret...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00243214
更新日期：1994-01-01 00:00:00
abstract：:We describe a new form of gamma-aminobutyric acid (GABA) -mediated regulation of the inactivation and of the recovery from inactivation of the L-type Ca2+ current (I(Ca)) in crayfish muscle. GABA (1 mM) was applied during a 2-min period and the peak I(Ca) was measured using two-electrode voltage-clamp recordings 30 mi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210000445
更新日期：2000-09-01 00:00:00
abstract：:The aim of this study was to evaluate the modulation of muscle activity during locomotor-like movements by different walking speeds in subjects with a motor complete spinal cord injury (SCI) compared to actively--and passively-walking control subjects without neurological deficit. Stepping movements on a treadmill wer...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0509-4
更新日期：2006-10-01 00:00:00
abstract：:Anatomical studies in several species have demonstrated a pallidostriatal pathway. We employed electrophysiological and anatomical methods to distinguish the neurones of this pathway from the two pallidocortical groups reported in the rat. Injection of fluorescent retrograde tracers, combined with immunohistochemistry...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248863
更新日期：1989-01-01 00:00:00
abstract：:The accomplishment of mature locomotor movements relies upon the integrated coordination of the lower and upper limbs and the trunk. Human adults normally swing their arms and a quadrupedal limb coordination persists during bipedal walking despite a strong corticospinal control of the upper extremities that allows to ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5201-y
更新日期：2018-04-01 00:00:00
abstract：:Corticofugal influence upon lateral geniculate units was evaluated by inactivating the visual cortex with a topical application of 3M KCL in rabbits. The results revealed a decrease of spontaneous firing in slow P cells following cortical depression suggesting a tonic corticofugal influence. The most consistently obse...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236189
更新日期：1977-09-28 00:00:00
abstract：:The gain (ratio of eye velocity to head velocity) of the initial horizontal vestibulo-ocular reflex (VOR) was calculated in 12 normal subjects over 350 ms during impulsive, unpredictable whole body rotation under three conditions: (1) darkness; (2) visual enhancement of the VOR, while the subjects fixated a stationary...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00239596
更新日期：1994-01-01 00:00:00
abstract：:Quantitative autoradiography was used to examine central binding sites for L-[3H]glutamate in amygdaloid-kindled rats since receptors for excitatory amino acids have been implicated in epileptiform activity and seizure behaviors. In tissue from rats killed five days after two kindled seizures, the ipsilateral hippocam...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231751
更新日期：1991-01-01 00:00:00
abstract：:This study compared the morphological characteristics and the behavioural effects of intrahippocampal septal cell suspension grafts injected either just above the pyramidal cell layer of the hippocampal region CA1 or within the dorsal leaf of the dentate gyrus (DG) in rats subjected to electrolytic fimbria-fornix lesi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227297
更新日期：1996-09-01 00:00:00
abstract：:The possibility of a cerebellar linkage, via the thalamus with medial area 6 of the cerebral cortex was further explored in the present experiments (cf. preceding companion paper). It was found that HRP conjugated to the lectin wheat germ agglutinin injected into motor cortical areas was transported beyond the thalamu...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237671
更新日期：1985-01-01 00:00:00
abstract：:The literature reports that anticipatory postural adjustments (APAs) are programmed according to movement velocity. However, the linkage between APAs and velocity has been highlighted within single subjects who were asked to voluntarily change movement velocity; therefore, till now, it has been impossible to discern w...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-014-4122-7
更新日期：2015-02-01 00:00:00
abstract：:The efficacy of inhibitory and excitatory intracortical circuits acting on the representation of an intrinsic hand muscle in the primary motor cortex of both hemispheres was measured with paired transcranial magnetic stimuli in right-handed subjects. Both intracortical inhibition (measured with an interstimulus interv...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-003-1696-x
更新日期：2004-03-01 00:00:00
abstract：:It is now accepted that performing a cognitive task impacts postural control (Polskaia and Lajoie 2016; Vuillerme et al. Neurosci Lett 291: 77-80, 2000). However, the reverse impact of posture on cognitive performance is less documented. The present study investigated performance in two cognitive activities (memory an...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05858-z
更新日期：2020-11-01 00:00:00
abstract：:When walking with a hand-held object, grip force is coupled in an anticipatory manner to changes in inertial force resulting from the accelerations and decelerations of gait. However, it is not known how grip and inertial forces are organized at the onset of gait, and if the two forces are coupled in the early phases ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1476-8
更新日期：2008-09-01 00:00:00
abstract：:Discrimination learning can cause improved and worsened ability to perceive differences. This subsequently affects how stimuli are associated with meanings and behaviors. Here, human listeners were trained with frequency-modulated (FM) tonal sweeps (500-1000 Hz) in a paradigm where one FM rate (8.29 octaves per second...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-016-4866-3
更新日期：2017-04-01 00:00:00
abstract：:We investigated the effect of foot position and foot orientation on asymmetrical body weight loading and the inter- and intra-foot coordination dynamics of standing postures. The participants were instructed to stand with the feet side-by-side and in staggered and tandem positions with the right foot oriented at diffe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3627-9
更新日期：2013-09-01 00:00:00
abstract：:Cellular relationships between serotonin (5-HT) axons and tyrosine hydroxylase (TH)-containing neurons were examined by combined (3H)5-HT uptake radioautography and TH immunocytochemistry in the medial zona incerta (ZI) of adult rats, 7 and 50 days after an intracerebral injection of 5,7-Dihydroxytryptamine (5,7-DHT)....
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00250592
更新日期：1988-01-01 00:00:00
abstract：:Parkinsonian rigidity is characterized by an increased resistance of a joint to externally imposed motion that remains uniform with changing joint angle. Two candidate mechanisms are proposed for the uniformity of rigidity, involving neural-mediated excitation of shortening muscles, i.e., shortening reaction (SR), or ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2594-2
更新日期：2011-04-01 00:00:00
abstract：:In the present study the neurotoxic effects of a low dosage (0.5 mg/kg per day) of methylmercury (MeHg) on the developing nervous system were investigated. Pregnant rats were treated with MeHg from day 7 of pregnancy to day 7 of lactation. Locomotor activity (locomotion, rearing, and motility) and spatial learning abi...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050237
更新日期：1997-12-01 00:00:00
abstract：:The cerebral representation of space depends on the integration of many different sensory inputs. The vestibular system provides one such input and its dysfunction can cause profound spatial disorientation. Using positron emission tomography (PET), we measured regional cerebral perfusion with various vestibular stimul...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/BF00241421
更新日期：1994-01-01 00:00:00
abstract：:Research on animal models as well as human subjects has demonstrated that the vestibular system contributes to regulating the distribution of blood in the body through effects on the sympathetic nervous system. Elimination of vestibular inputs results in increased blood flow to the hindlimbs during vestibular stimulat...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2550-1
更新日期：2011-05-01 00:00:00
abstract：:The present study used a force-matching task to measure how accurately subjects could match a force using different muscle groups. Forces ranging in magnitude from 2 to 10 N were produced and matched by three muscle groups: the elbow flexors, the forearm and hand muscles involved in the palmar prehensile grasp, and th...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s00221-003-1434-4
更新日期：2003-07-01 00:00:00
