Abstract：
:The European Resuscitation Guidelines recommend that survivors of cardiac arrest (CA) be resuscitated with 100% O2 and undergo subsequent-post-return of spontaneous circulation (ROSC)-reduction of O2 supply to prevent hyperoxia. Hyperoxia produces a "second neurotoxic hit," which, together with the initial ischemic insult, causes ischemia-reperfusion injury. However, heterogeneous results from animal studies suggest that normoxia can also be detrimental. One clear reason for these inconsistent results is the considerable heterogeneity of the models used. In this study, the histological outcome of the hippocampal CA1 region following resuscitation with 100% O2 combined with different post-ROSC ventilation regimes (21%, 50%, and 100% O2) was investigated in a rat CA/resuscitation model with survival times of 7 and 21 days. Immunohistochemical stainings of NeuN, MAP2, GFAP, and IBA1 revealed a neuroprotective potency of post-ROSC ventilation with 21% O2, although it was only temporary. This limitation should be because of the post-ROSC intervention targeting only processes of ischemia-induced secondary injury. There were no ventilation-dependent effects on either microglial activation, reduction of which is accepted as being neuroprotective, or astroglial activation, which is accepted as being able to enhance neurons' resistance to ischemia/reperfusion injury. Furthermore, our findings verify the limited comparability of animal studies because of the individual heterogeneity of the animals, experimental regimes, and evaluation procedures used.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Keilhoff G,Titze M,Rathert H,Lucas B,Esser T,Ebmeyer Udoi
10.1007/s00221-020-05746-6subject
Has Abstractpub_date
2020-04-01 00:00:00pages
807-824issue
4eissn
0014-4819issn
1432-1106pii
10.1007/s00221-020-05746-6journal_volume
238pub_type
杂志文章abstract：:Mechanosensation associated with precise orofacial force regulation may contribute considerably to processes associated with perception, proprioception and sensorimotor control due to the direct coupling between orofacial skin and the underlying musculature. Recent investigations have demonstrated that dynamic, low-le...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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更新日期：2003-08-01 00:00:00
abstract：:Filial imprinting was originally proposed to be an irreversible process by which a young animal forms a preference for an object experienced early in life. The present study examined the effects of experience after imprinting on the stability of preferences of domestic chicks (Gallus gallus domesticus) for an imprinti...
journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章,随机对照试验
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更新日期：2012-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1437-2
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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