Abstract:
:Static and dynamic otolith, horizontal vestibular and optokinetic ocular reflexes were investigated in pigmented rats 1-6 and more months after unilateral vestibular nerve (UVN) section. Evoked responses were compared with published data from control rats studied under identical conditions. Static lateral tilt of UVN rats in the light evoked a vertical deviation in static eye position that was as large as in controls. In darkness, the evoked responses in UVN rats 6 months after the lesion were consistently smaller than in controls. Linear horizontal acceleration in darkness evoked vertical and torsional response components in UVN rats that were parallel-shifted towards lower gains and larger phase lags. Off-vertical axis rotation on a platform provoked responses that differed markedly from those recorded in intact rats with respect to the bias velocity component. These results suggest a permanent deficiency in the static and dynamic otolith-ocular reflex performance of UVN rats. Ocular responses to horizontal table velocity steps in darkness exhibited a direction-specific asymmetry in UVN rats. Step responses evoked by acceleration towards the intact side were larger in gain and longer in duration than responses evoked by acceleration towards the operated side. When compared with control data, responses to either side were reduced in UVN rats and the velocity store mechanism was barely activated by velocity steps towards the operated side. Responses evoked by horizontal optokinetic stimulation with constant pattern velocities were below control values in either direction. Slow-phase eye velocity saturated at much lower values than in intact rats, particularly during pattern motion towards the intact side. The duration of the optokinetic afternystagmus was asymmetrically reduced with respect to control data. Practically identical reductions in duration were found for vestibulo-ocular responses in the opposite directions. Behaving animals exhibited no obvious impairment in their spontaneous locomotory or exploratory activities. However, each UVN rat was impaired, even 2 years after the lesion, in its postural reaction to being lifted by the tail in the air. This observation suggests the presence of a permanent deficit in static and dynamic otolith-spinal reflexes that may be substituted on the ground by proprioceptive inputs.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Hamann KF,Reber A,Hess BJ,Dieringer Ndoi
10.1007/s002210050287subject
Has Abstractpub_date
1998-02-01 00:00:00pages
331-40issue
3eissn
0014-4819issn
1432-1106journal_volume
118pub_type
杂志文章abstract::In order to assess the autoinhibitory control of endogenous acetylcholine (ACh) in rat and human neocortex, slices of these tissues were prelabelled with [(3)H]choline, superfused continuously and stimulated electrically using various frequencies in the presence or absence of drugs. The autoinhibitory feedback control...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050858
更新日期:1999-10-01 00:00:00
abstract::In the frog's isolated head preparations, spontaneous activity was recorded from the whole nerve of the left horizontal semicircular canal (HC) for 6 min before and 16 min after destruction of the right labyrinth by heating or administration of d-tubocurarine (0.5 microliter, 5.10(-6)M) into the perilymph of the right...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235790
更新日期:1982-01-01 00:00:00
abstract::Prior research has concluded that the correlations of isometric finger forces represent the extent to which the fingers are controlled as a single unit. If this is the case, finger force correlations should be consistent with estimates of the controlled (dynamical) degrees of freedom in finger forces. The present stud...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-012-3280-8
更新日期:2012-12-01 00:00:00
abstract::A central network of neurones in the spinal cord has been shown to produce a rhythmic motor output similar to locomotion after suppression of all afferent inflow. The experiments were performed mainly in acute spinal cats (th. 12), which had received DOPA i.v. and the monoamine oxidase inhibitor Nialamide. In some pre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235671
更新日期:1979-01-15 00:00:00
abstract::In order to find out whether human vergence eye movements are influenced by simultaneous hand tracking movements, vergence was studied when sinusoidal (expressed in vergence angles) target movements were tracked. The target motion was externally generated and the target actually moved in depth. Tracking was done by th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00234117
更新日期:1993-01-01 00:00:00
abstract::Organotypic slice cultures of striatum and neocortex were prepared from newborn to seven day old rats and cultured for three to 60 days. When processed for tyrosine hydroxylase (TH) immunocytochemistry medium-sized, aspiny TH immunoreactive (TH-i) neurons with a similar morphology were revealed in the striatum and the...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231159
更新日期:1991-01-01 00:00:00
abstract::Perception of our own bodies is based on integration of visual and tactile inputs, notably by neurons in the brain's parietal lobes. Here we report a behavioural consequence of this integration process. Simply viewing the arm can speed up reactions to an invisible tactile stimulus on the arm. We observed this visual e...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1651-x
更新日期:2004-01-01 00:00:00
abstract::The uptake of L-glutamate was studied in astrocytes cultured from different brain areas of newborn rats as well as in two different cultures of neurons obtained from mouse brain. Both astrocytes and neurons exhibited high-affinity glutamate uptake with Km values ranging from 34 microM to 82 microM. Vmax values for ast...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239385
更新日期:1982-01-01 00:00:00
abstract::A strong assumption shared by major theoretical approaches to cognition posits that the human cognitive system has a limited capacity for information processing. Evidence supporting this claim comes from the dual-task paradigm in which one cognitive system has to process two tasks simultaneously. In this study, we exa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2703-2
更新日期:2011-06-01 00:00:00
abstract::Delay eyeblink conditioning was examined in patients with genetically-defined heredoataxias and age-matched control subjects. 24 patients with spinocerebellar ataxia type 6 (SCA6), type 3 (SCA3), and Friedreich's ataxia (FRDA) participated. SCA6 affects primarily the cerebellum, whereas extracerebellar involvement is ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2181-x
更新日期:2005-04-01 00:00:00
abstract::The blocking effect of triethyldodecylammoniumbromide (TEA-C12), applied locally to the sciatic nerve, was studied in 28 adult BDF1 mice. Clinical parameters, electrophysiological recordings of muscle action potentials evoked by stimulation at the sciatic notch, and morphological aspects are presented. Our results sho...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248862
更新日期:1989-01-01 00:00:00
abstract::In order to examine the stability and patterning of speech movement sequences, movements of the lip were recorded as subjects produced a phrase at normal, fast, and slow rates. Three methods of analysis were employed. First, a new index of spatiotemporal stability was derived by summing the standard deviations compute...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00231983
更新日期:1995-01-01 00:00:00
abstract::Dissociated cell suspensions were prepared from the ventral midbrain of normal mouse foetuses and stereotaxically implanted into the neostriatum of 2-3 months old homozygous weaver mutant mice, which are severely deficient in dopamine. In tests of amphetamine-induced turning behaviour 60 days after grafting, recipient...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228869
更新日期:1990-01-01 00:00:00
abstract::Slice cultures from the visual cortex of young rats were prepared using the roller culture technique (Gähwiler 1984). After 10 days in vitro the cortical cultures flattened to 1-3 cell layers, surviving for up to 12 weeks. The cultures were organotypically organized, the typical layered structure of the cortex was pre...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00274981
更新日期:1989-01-01 00:00:00
abstract::The mechanisms underlying stress-induced hyperalgesia (SIH) remain poorly understood. Recent findings have provided strong evidence indicating that SIH could be related, at least in part, to alterations in spinal cord GABA activity. In the present study, we first investigated how acute restraint stress impacted pain r...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-014-4027-5
更新日期:2014-11-01 00:00:00
abstract::Chemoreceptor pathways from the vomeronasal organ (VNO), and main olfactory system are known to be separate as they pass into the brain, at least until the level of the amygdala. In the amygdala, vomeronasal pathways project to the posteromedial cortical nucleus (PMCN), and medial nucleus (MN). The main olfactory path...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247024
更新日期:1987-01-01 00:00:00
abstract::Filial imprinting was originally proposed to be an irreversible process by which a young animal forms a preference for an object experienced early in life. The present study examined the effects of experience after imprinting on the stability of preferences of domestic chicks (Gallus gallus domesticus) for an imprinti...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2769-x
更新日期:2011-08-01 00:00:00
abstract::Judgments on laterality of hand stimuli are faster and more accurate when dealing with one's own than others' hand, i.e. the self-advantage. This advantage seems to be related to activation of a sensorimotor mechanism while implicitly processing one's own hands, but not during explicit one's own hand recognition. Here...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4210-3
更新日期:2015-04-01 00:00:00
abstract::The vestibulo-ocular reflex (VOR) was intermittently suppressed by fixating a head-fixed target (light on: 9 s; darkness: 2 s) during whole-body (60-100 deg/s peak; 0.01-0.17 Hz) sinusoidal and triangular oscillation about the vertical axis for about 2 min. Eye movements associated with intervals of darkness at differ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00261343
更新日期:1985-01-01 00:00:00
abstract::Three patients with cerebellar limb ataxia and three age-matched controls performed arm-pointing movements towards a visual stimulus during an experimental procedure using a double-step paradigm in a three-dimensional space. Four types of trajectories were defined: P1, single-step pointing movement towards the visual ...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050361
更新日期:1998-04-01 00:00:00
abstract::Multisensory integration is known to create a more robust and reliable perceptual representation of one's environment. Specifically, a congruent auditory input can make a visual stimulus more salient, consequently enhancing the visibility and detection of the visual target. However, it remains largely unknown whether ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4591-y
更新日期:2016-05-01 00:00:00
abstract::The development of the electromyogram (EMG) of tibialis anterior (TA) and medial gastrocnemius (GM) during locomotion was studied in normal rats from the onset of quadruped walking (postnatal day 10, P10) until P42. The objectives were to relate signal properties of the EMG and coordination of muscle activity to funct...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229036
更新日期:1993-01-01 00:00:00
abstract::In a recent study (Whitwell et al. in Exp Brain Res 185:111-119, 2008), we showed that the visuomotor system is "cognitively impenetrable" to the extent that explicit predictive knowledge of the availability of visual feedback on an upcoming trial fails to optimize grasping. The results suggested that the effects of t...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1737-1
更新日期:2009-04-01 00:00:00
abstract::We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230292
更新日期:1993-01-01 00:00:00
abstract::A photographic technique was used to study the evolution of lateral head-tilt following hemilabyrinthectomy in adult cats. Animals were maintained post-operatively in normally lit conditions (LM cats), in total darkness (DM cats), or in stroboscopic light. In LM casts, the head tilt peaked at 45 degrees (with the lesi...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235707
更新日期:1977-06-27 00:00:00
abstract::We have reported previously that intracranial application of near-infrared light (NIr) reduces clinical signs and offers neuroprotection in a subacute MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) monkey model of Parkinson's disease. In this study, we explored whether NIr reduces the gliosis in this animal model...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4720-7
更新日期:2016-11-01 00:00:00
abstract::We have studied the contribution of feedback signals originating from one of the "form-processing" extrastriate cortical areas, area 21a (A21a), to orientation selectivity of single neurons in the ipsilateral area 17 (A17). Consistent with previous findings, reversible inactivation (cooling to 5-10 degrees C) of area ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1014-0
更新日期:2007-10-01 00:00:00
abstract::The purpose of this study was to investigate whether repetitive electrical stimulation of the common peroneal nerve (CPN) is associated with changes in the motor response of the tibialis anterior (TA) muscle elicited by focal magnetic stimulation of the motor cortex. Motor evoked potentials (MEP) with a stimulation in...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1094-9
更新日期:2002-08-01 00:00:00
abstract::The time course of development of visual acuity for square wave gratings was measured behaviourally in a number of cats that were reared in total darkness until they were either 4 (5 cats) or 6 (1 cat) months of age. Less extensive measurements were also made on animals reared in a similar manner until they were eithe...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239811
更新日期:1978-04-14 00:00:00
abstract::Although a number of studies have demonstrated state-related dependence of auditory steady-state responses (ASSRs), the investigations assessing trait-related ASSR changes are limited. Five consistently identified major trait dimensions, also referred to as "big five" (Neuroticism, Extraversion, Openness, Agreeablenes...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4494-3
更新日期:2016-03-01 00:00:00