Abstract:
:Organotypic slice cultures of striatum and neocortex were prepared from newborn to seven day old rats and cultured for three to 60 days. When processed for tyrosine hydroxylase (TH) immunocytochemistry medium-sized, aspiny TH immunoreactive (TH-i) neurons with a similar morphology were revealed in the striatum and the neocortex. The neurons had a very similar morphology in both tissues and were present both when the two tissues were grown separately as single cultures and when grown together either en bloc as part of the same tissue slices or as co-cultures. In order to examine whether innervation by dopaminergic fibers would affect the expression of TH-i neurons in the striatal slice cultures, co-cultures of ventral mesencephalon (VM) and striatum were prepared, but the ingrowth of TH-i fibers from the VM did not alter the expression of TH immunoreactivity by a subpopulation of striatal neurons.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Ostergaard K,Schou JP,Gähwiler BH,Zimmer Jdoi
10.1007/BF00231159subject
Has Abstractpub_date
1991-01-01 00:00:00pages
357-65issue
2eissn
0014-4819issn
1432-1106journal_volume
83pub_type
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