Dopaminergic innervation of the rat globus pallidus characterized by microdialysis and immunohistochemistry.

Abstract:

:The present study examined the dopaminergic innervation of the rat globus pallidus by in vivo microdialysis and immunohistochemistry in more detail. Using tyrosine hydroxylase immunohistochemistry, two classes of dopaminergic fibers were distinguished morphologically in the globus pallidus. Unilateral infusion of 6-hydroxydopamine into the substantia nigra produced a loss of dopaminergic fiber density in the globus pallidus which was correlated with the nigral extent of the lesion. These findings are in line with the notion that a degenerative loss of nigral dopaminergic cell bodies might also affect the dopamine input of extrastriatal structures such as the globus pallidus. Using in vivo microdialysis, we tested whether dopamine measured in the globus pallidus is of neuronal origin. Perfusion of tetrodotoxin induced a strong and transient decrease of pallidal dopamine. The tetrodotoxin-sensitivity of pallidal dopamine demonstrates the functional significance of the nigropallidal dopaminergic innervation.

journal_name

Exp Brain Res

authors

Fuchs H,Hauber W

doi

10.1007/s00221-003-1638-7

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

66-75

issue

1

eissn

0014-4819

issn

1432-1106

journal_volume

154

pub_type

杂志文章
  • Movement-specific enhancement of corticospinal excitability at subthreshold levels during motor imagery.

    abstract::This study examined modulation of corticospinal excitability during both actual and imagined movements. Seven young healthy subjects performed actual (3-50% maximal voluntary contractions) and imagined index finger force production, and rest. Individual responses to focal transcranial magnetic stimulation (TMS) in fou...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0809-8

    authors: Li S

    更新日期:2007-05-01 00:00:00

  • Do walkers follow their heads? Investigating the role of head rotation in locomotor control.

    abstract::Eye and head rotations are normally correlated with changes in walking direction; however, it is unknown whether they play a causal role in the control of steering. The objective of the present study was to answer two questions about the role of head rotations in steering control when walking to a goal. First, are hea...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3077-9

    authors: Cinelli M,Warren WH

    更新日期:2012-06-01 00:00:00

  • Liminal and supraliminal response characteristics of mechanoreceptive neurons in the cuneate nucleus of cat.

    abstract::The response characteristics of mechanoreceptive neurons (RA, SA, and PC) innervating the foot pad of cat were determined in the cuneate nucleus. The mechanical stimuli were single sinusoidal pulses of varying frequency (20, 60, 150, and 240 Hz), and vibratory trains of varying frequency (80 and 240 Hz) and duration (...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236027

    authors: Pertovaara A,Huopaniemi T,Tukeva T

    更新日期:1986-01-01 00:00:00

  • Shift of chloride reversal potential in neurons of the accessory optic system in albinotic rats.

    abstract::Albinism affects the anatomy and physiology of the visual system in mammals. Behavioural, anatomical and in vivo electrophysiological investigations revealed that the optokinetic reflex is abnormal and retinal slip neurons in the nucleus of the optic tract and the dorsal terminal nucleus of the accessory optic system ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1722-8

    authors: Krause M,Hoffmann KP

    更新日期:2009-12-01 00:00:00

  • Pathological and experimentally induced blindness induces auditory activity in the cat primary visual cortex.

    abstract::Early blindness in humans and experimental visual deprivation in animal models are known to induce compensatory somatosensory and/or auditory activation of the visual cortex. An abnormal hydrocephalic cat with extreme malformation of the visual system, born in our breeding colony, rendered a good model system for inve...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002219900295

    authors: Yaka R,Yinon U,Rosner M,Wollberg Z

    更新日期:2000-03-01 00:00:00

  • Perceiving emotion in crowds: the role of dynamic body postures on the perception of emotion in crowded scenes.

    abstract::Although the perception of emotion in individuals is an important social skill, very little is known about how emotion is determined from a crowd of individuals. We investigated the perception of emotion in scenes of crowds populated by dynamic characters each expressing an emotion. Facial expressions were masked in t...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-2037-5

    authors: McHugh JE,McDonnell R,O'Sullivan C,Newell FN

    更新日期:2010-07-01 00:00:00

  • Shifts of cortical d.c. potential induced by application of gamma-aminobutyric acid in rats in vivo.

    abstract::Generally, increases in cortical activity go in parallel with negative shifts and decreases with positive shifts of cortical d.c. potentials. The aim of the present investigation was to test the effects of the inhibitory transmitter gamma-aminobutyric acid (GABA) and of GABA receptor agonists on cortical d.c. potentia...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/pl00005614

    authors: Lücke A,Woesler B,Speckmann EJ

    更新日期:1997-03-01 00:00:00

  • Responses to coloured patterns in the macaque lateral geniculate nucleus: pattern processing in single neurones.

    abstract::Cell responses to complex visual patterns such as compositions of broad-band (non-monochromatic) colour areas are presented. Patterns were scanned over the receptive field, and cell response at each point was recorded. "Response patterns" were constructed which display the cell transform of the stimulus pattern. Parvo...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00239571

    authors: Nothdurft HC,Lee BB

    更新日期:1982-01-01 00:00:00

  • Effects of delayed auditory and visual feedback on sequence production.

    abstract::This study represents the first systematic comparison of the relative contributions of auditory and visual feedback to sequence production. Participants learned an isochronous melody that they performed on a keyboard and attempted to perform this sequence at a prescribed rate while auditory and visual feedback were ma...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3289-z

    authors: Kulpa JD,Pfordresher PQ

    更新日期:2013-01-01 00:00:00

  • Do component motions recombine into a moving plaid percept?

    abstract::Two superimposed gratings, which differ in orientation and move independently, combine into a coherently moving plaid if the component gratings are similar. The effect on the plaid motion percept of the addition of texture to each grating was investigated. The texture disambiguates the motion of each component grating...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228400

    authors: van den Berg AV,van de Grind WA

    更新日期:1993-01-01 00:00:00

  • Medium-latency reflex response of soleus elicited by peroneal nerve stimulation.

    abstract::A medium-latency response (MLR) has been recorded from soleus during stance and walking, and has been attributed to stretch-evoked volleys in group II afferents. The present paper describes a MLR in soleus evoked by stimulating the deep peroneal nerve, documents its characteristics and addresses its likely origin. The...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-008-1621-4

    authors: Uysal H,Larsson LE,Efendi H,Burke D,Ertekin C

    更新日期:2009-02-01 00:00:00

  • How two share two tasks: evidence of a social psychological refractory period effect.

    abstract::A strong assumption shared by major theoretical approaches to cognition posits that the human cognitive system has a limited capacity for information processing. Evidence supporting this claim comes from the dual-task paradigm in which one cognitive system has to process two tasks simultaneously. In this study, we exa...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2703-2

    authors: Liepelt R,Prinz W

    更新日期:2011-06-01 00:00:00

  • N-methyl-D-aspartate-evoked calcium uptake by kitten visual cortex maintained in vitro.

    abstract::As a functional measure of NMDA receptor effectiveness in kitten striate cortex, the uptake of 45Ca by visual cortical slices was measured after 2 minute bath applications of N-methyl-D-aspartate (NMDA). Significant Ca uptake occurred in response to 12.5-100 microM NMDA in slices prepared from visual cortex of normal ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228153

    authors: Feldman D,Sherin JE,Press WA,Bear MF

    更新日期:1990-01-01 00:00:00

  • Spatiotemporal surface EMG characteristics from rat triceps brachii muscle during treadmill locomotion indicate selective recruitment of functionally distinct muscle regions.

    abstract::Multichannel surface EMG recordings of a multiheaded skeletal muscle during cyclic locomotion combined with cineradiography were analysed in a chronic experiment. The resulting detailed two-dimensional activation pattern from the long and lateral triceps brachii heads of the rat during treadmill locomotion were combin...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210100685

    authors: Scholle HC,Schumann NP,Biedermann F,Stegeman DF,Grassme R,Roeleveld K,Schilling N,Fischer MS

    更新日期:2001-05-01 00:00:00

  • Excitation and sensitization of nociceptors by bradykinin: what do we know?

    abstract::Bradykinin is an endogenous nonapeptide known to induce pain and hyperalgesia to heat and mechanical stimulation. Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of nociceptors is not well established. Protein kinase C and TR...

    journal_title:Experimental brain research

    pub_type: 杂志文章,评审

    doi:10.1007/s00221-009-1814-5

    authors: Mizumura K,Sugiura T,Katanosaka K,Banik RK,Kozaki Y

    更新日期:2009-06-01 00:00:00

  • Adaptational effects during human split-belt walking: influence of afferent input.

    abstract::The modification of the normal locomotor pattern of humans was investigated using a split-belt locomotion protocol (treadmill belt speeds of 4.5 km/h and 1.5 km/h for the right and left legs, respectively) and also by changing afferent input from the legs (30% reduction or increase in body weight by suspending subject...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002210050262

    authors: Jensen L,Prokop T,Dietz V

    更新日期:1998-01-01 00:00:00

  • Responses to paired transcranial magnetic stimuli in resting, active, and recently activated muscles.

    abstract::Transcranial magnetic stimulation (TMS) causes the corticospinal system to become refractory to subsequent stimuli for up to 200 ms. We examined the phenomenon of paired pulse inhibition with TMS under conditions of rest, ongoing voluntary activation (isometric force generation), and at variable delays following activ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00228638

    authors: Wassermann EM,Samii A,Mercuri B,Ikoma K,Oddo D,Grill SE,Hallett M

    更新日期:1996-04-01 00:00:00

  • Identifying brain regions for integrative sensorimotor processing with ankle movements.

    abstract::The objective of this study was to define cortical and subcortical structures activated during both active and passive movements of the ankle, which have a fundamental role in the physiology of locomotion, to improve our understanding of brain sensorimotor integration. Sixteen healthy subjects, all right-foot dominant...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-005-2335-5

    authors: Ciccarelli O,Toosy AT,Marsden JF,Wheeler-Kingshott CM,Sahyoun C,Matthews PM,Miller DH,Thompson AJ

    更新日期:2005-09-01 00:00:00

  • Distribution of the calcium-binding proteins calbindin D-28K and parvalbumin in the superior colliculus of adult and neonatal cat and rhesus monkey.

    abstract::The distribution of the calcium-binding proteins calbindin D-28K and parvalbumin was examined in newborn and adult superior colliculus of cat and rhesus monkey using immunohistochemical techniques. In adult animals of both species, calbindin-immunoreactive neurons had a three-tiered arrangement: one band was present i...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-001-0908-5

    authors: McHaffie JG,Anstrom KK,Gabriele ML,Stein BE

    更新日期:2001-12-01 00:00:00

  • After-effects of visuo-manual adaptation to prisms on body posture in normal subjects.

    abstract::Postural equilibrium is known to be controlled by sensorimotor reflexes and automatic control loops but also depends on high-level body representation in space, probably implicating the right temporoparietal cortex. Indeed, short-term prism adaptation to a 10 degrees rightward visual shift has been shown to reduce pre...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-002-1294-3

    authors: Michel C,Rossetti Y,Rode G,Tilikete C

    更新日期:2003-01-01 00:00:00

  • Binocular interactions in the lateral geniculate nucleus of the cat: GABAergic inhibition reduced by dominant afferent activity.

    abstract::Single cells were recorded in layers A and A1 of the cat dorsal lateral geniculate nucleus (dLGN) with multibarrel micropipettes. Interocular inhibition ("binocular inhibition") was elicited by phase-reversing gratings presented monocularly to the nondominant eye. This inhibition was blocked by microiontophoretic appl...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00239516

    authors: Pape HC,Eysel UT

    更新日期:1986-01-01 00:00:00

  • Contribution of corticospinal drive to ankle plantar flexor muscle activation during gait in adults with cerebral palsy.

    abstract::Impaired plantar flexor muscle activation during push-off in late stance contributes importantly to reduced gait ability in adults with cerebral palsy (CP). Here we used low-intensity transcranial magnetic stimulation (TMS) to suppress soleus EMG activity during push-off as an estimate of corticospinal drive in CP adu...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-019-05520-3

    authors: Frisk RF,Lorentzen J,Nielsen JB

    更新日期:2019-06-01 00:00:00

  • Involvement of GABA in medullary raphe-evoked modulation of neuronal activity in the periaqueductal grey matter in the rat.

    abstract::Experiments were carried out in urethane-anaesthetised rats to investigate whether GABA is involved in mediating inhibition of neuronal activity in the dorsal half of the periaqueductal grey matter (PAG) after stimulation of the serotonin-containing projection to the PAG from nucleus raphe obscurus (NRO). Multibarrell...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000627

    authors: Lovick TA

    更新日期:2001-03-01 00:00:00

  • Relationship between motor activity-related cortical potential and voluntary muscle activation.

    abstract::The purpose of this study was to investigate the relationship between EEG-derived motor activity-related cortical potential (MRCP) and voluntary muscle activation. Eight healthy volunteers participated in two experimental sessions. In one session, subjects performed isometric elbow-flexion contractions at four intensi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000382

    authors: Siemionow V,Yue GH,Ranganathan VK,Liu JZ,Sahgal V

    更新日期:2000-08-01 00:00:00

  • Does calculating impair postural stabilization allowed by visual cues?

    abstract::In many daily situations, balance control is associated with a cognitive activity such as reading or a simple calculation. The objective of this study was to investigate the relationship between these two specific human activities, especially the influence of visual cues and support surface stability on body sway duri...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-014-3913-1

    authors: Ceyte H,Lion A,Caudron S,Kriem B,Perrin PP,Gauchard GC

    更新日期:2014-07-01 00:00:00

  • Transcallosally mediated inhibition of interneurons within human primary motor cortex.

    abstract::The objective of this study was to investigate interhemispheric transcallosal connections between primary motor cortices noninvasively in awake human subjects. For this purpose, focal transcranial magnetic stimulation was performed on eight healthy, right-handed subjects and one patient with congenital collosal agenes...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00227944

    authors: Schnitzler A,Kessler KR,Benecke R

    更新日期:1996-12-01 00:00:00

  • Effects of speeding up or slowing down animate or inanimate motions on timing.

    abstract::It has recently been suggested that time perception and motor timing are influenced by the presence of biological movements and animacy in the visual scene. Here, we investigated the interactions among timing, speed and animacy in two experiments. In Experiment 1, observers had to press a button in synchrony with the ...

    journal_title:Experimental brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00221-012-3338-7

    authors: Carrozzo M,Lacquaniti F

    更新日期:2013-02-01 00:00:00

  • The effects of strobe rate of head-fixed visual targets on suppression of vestibular nystagmus.

    abstract::The effects of degrading retinal image velocity information on suppression of the vestibulo-ocular reflex have been assessed through tachistoscopic presentation of target sources in man. Subjects were required to fixate a head-fixed display during exposure to a 0.5 Hz sinusoidal angular oscillation of the head at +/- ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00239187

    authors: Barnes GR,Edge A

    更新日期:1983-01-01 00:00:00

  • Effect of contrast on spatial frequency tuning of neurones in area 17 of cat's visual cortex.

    abstract::Previous investigations have revealed that perceived spatial frequency of gratings rises as contrast is lowered. In order to account for this finding it has been postulated that the spatial frequency which produces the maximum response from cortical neurones decreases with contrast. We have examined this hypothesis by...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236862

    authors: Skottun BC,Bradley A,Ramoa AS

    更新日期:1986-01-01 00:00:00

  • Visual capture influences body-based indications of visual extent.

    abstract::Visual information regarding limb location can override proprioceptive information when there is conflict between the two-a phenomenon referred to as visual capture. In three experiments, we employed the "mirror illusion," in which the perceived location of one's hand is influenced by the visual information specified ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-010-2445-6

    authors: Kunz BR,Creem-Regehr SH,Thompson WB

    更新日期:2010-12-01 00:00:00