Abstract:
:The survival of grafts of dissociated allogeneic fetal neural dopamine (DA) rich tissue in the striatum has been studied after transplantation between inbred strains of mice differing at defined immunogenetical loci between donor and recipient. Six to 7 weeks and 15 weeks after grafting, surviving grafted DA neurons were found in the brains of all the recipients, albeit with a large variation in numbers, located either within the striatum or within the adjacent lateral ventricle. The mean number of surviving DA neurons did not differ between the syngeneic controls and the histoincompatible donor-host combinations, and there was no difference in survival between grafts that differed at single or multiple major histocompatibility complex (MHC) loci, and those that differed at multiple non-MHC loci. The amount of inflammatory cells in the graft area did not differ between the groups, and none of the animals showed massive infiltration of inflammatory cells. The in situ immunogenicity of the grafted neural tissue after intracerebral implantation was monitored by means of Simonsen's alloimmunization test, at 6-7 weeks after transplantation, which provides a sensitive measure primarily of the cellular immunological response. Most, but not all, graft recipients showed immunization with a Spleen Index (S.I.) close to that seen in recipients of an orthotopical skin graft of the same histoincompatibility combination. In contrast to the prolonged survival of the intracerebral neural transplants, none of the skin grafts survived longer than 3 weeks, thus demonstrating the immunologically privileged status of the brain. We conclude that intracerebrally grafted allogeneic neural tissue is capable of provoking a cellular immune response. Despite host immunization, however, the dissociated fetal neural allografts survived for at least 15 weeks without any overt signs of rejection, regardless of the donor-host combination used.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Widner H,Brundin P,Björklund A,Möller Edoi
10.1007/BF00253636subject
Has Abstractpub_date
1989-01-01 00:00:00pages
187-97issue
1eissn
0014-4819issn
1432-1106journal_volume
76pub_type
杂志文章abstract::The position of the center of gravity (CG) is a reference value that is controlled by the nervous system during the performance of movements. In order to maintain equilibrium, leg movement is preceded by a shift of the CG towards the supporting side. This CG shift is initiated by an early displacement of the center of...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050453
更新日期:1998-07-01 00:00:00
abstract::The thalamic projections to the cortical area surrounding the anterior (ASs) and middle (MSs) suprasylvian sulci in the cat were studied using horseradish peroxidase histochemistry. The medial MSs area (medial wall of the MsS) receives thalamic afferents from the pulvinar-lateralis posterior (Pul-LP) complex, posterio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235763
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00229824
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s00221-008-1655-7
更新日期:2009-02-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228385
更新日期:1993-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237573
更新日期:1986-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239743
更新日期:1975-09-29 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1009-x
更新日期:2007-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247578
更新日期:1988-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236293
更新日期:1984-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1038-4
更新日期:2002-05-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00248508
更新日期:1988-01-01 00:00:00
abstract::Sudden stretch of active muscle typically results in two characteristic electromyographic responses: the short latency M1 and the long latency M2. The M1 response originates from the monosynaptic Ia afferent reflex pathway. The M2 response is less well understood and is likely a compound response to different afferent...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1647-7
更新日期:2009-03-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/BF00227346
更新日期:1994-01-01 00:00:00
abstract::After intracranial transection of the optic nerve in cats the retinal stump of the nerve was injected with HRP. Surviving retinal ganglion cells can be retrogradely labeled at least up to 15.5 months of postoperative survival. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00261356
更新日期:1985-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050585
更新日期:1998-12-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2823-8
更新日期:2011-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235998
更新日期:1987-01-01 00:00:00
abstract::In the cat it is known that the distribution and modulation of the so-called P2 responses are similar, irrespective of whether they are obtained with electrodes implanted in the different skin areas or in the various leg muscles. In man it is known that the specific stimulation of cutaneous afferents from different pa...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1366-4
更新日期:2003-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-1847-8
更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238096
更新日期:1982-01-01 00:00:00
abstract::Arm motor performance of eight Cebus monkeys was examined during reversible cooling in the ventral lateral region of the putamen and globus pallidus (primarily the external segment), where neurons discharging during arm movements have been found (DeLong 1972). When attempting to hold a handle stationary during basal g...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237552
更新日期:1980-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238613
更新日期:1982-01-01 00:00:00
abstract::In 12 subjects, each sitting on an armchair with the right forearm prone, the H-reflex elicited in the resting flexor carpi radialis muscle underwent cyclic excitability changes correlated with rhythmic flexion-extension movements of the ipsilateral foot (frequency of oscillations between 1.5 and 2.5 Hz). During foot ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050297
更新日期:1998-02-01 00:00:00
abstract::In an attempt to identify cholinergic neurons of the brain stem which project to the forebrain, retrograde labeling of neurons in the brain stem was examined by autoradiography following injections of 20 microCi [3H]choline into the thalamus, hypothalamus, basal forebrain and frontal cortex. After injections into the ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236317
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1476-8
更新日期:2008-09-01 00:00:00