Abstract：
:Repetitive finger tapping is a well-established clinical test for the evaluation of parkinsonian bradykinesia, but few studies have investigated other finger movement modalities. We compared the kinematic changes (movement rate and amplitude) and response to levodopa during a conventional index finger-thumb-tapping task and an unconstrained index finger flexion-extension task performed at maximal voluntary rate (MVR) for 20 s in 11 individuals with levodopa-responsive Parkinson's disease (OFF and ON) and 10 healthy age-matched controls. Between-task comparisons showed that for all conditions, the initial movement rate was greater for the unconstrained flexion-extension task than the tapping task. Movement rate in the OFF state was slower than in controls for both tasks and normalized in the ON state. The movement amplitude was also reduced for both tasks in OFF and increased in the ON state but did not reach control levels. The rate and amplitude of movement declined significantly for both tasks under all conditions (OFF/ON and controls). The time course of rate decline was comparable for both tasks and was similar in OFF/ON and controls, whereas the tapping task was associated with a greater decline in MA, both in controls and ON, but not OFF. The findings indicate that both finger movement tasks show similar kinematic changes during a 20-s sustained MVR, but that movement amplitude is less well sustained during the tapping task than the unconstrained finger movement task. Both movement rate and amplitude improved with levodopa; however, movement rate was more levodopa responsive than amplitude.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Teo WP,Rodrigues JP,Mastaglia FL,Thickbroom GWdoi
10.1007/s00221-013-3491-7subject
Has Abstractpub_date
2013-06-01 00:00:00pages
323-31issue
3eissn
0014-4819issn
1432-1106journal_volume
227pub_type
杂志文章abstract：:1. Unit spikes of burst neurons were extracellularly recorded in the pontomedullary reticular formation of the cat. These neurons were identified by their burst activity coincident with the quick inhibitory phase of the contralateral abducens nerve during vestibular nystagmus and their antidromic activation from the c...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235558
更新日期：1978-11-15 00:00:00
abstract：:The hypoglossal nucleus (Mo12) contains motoneurons that innervate the tongue, while the motor trigeminal nucleus (Mo5) contains motoneurons that elevate or depress the mandible. Previous studies have revealed lateral and medial tegmental field neuronal afferents to the Mo12 adjacent to, but not within, the motor trig...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227237
更新日期：1992-01-01 00:00:00
abstract：:After injection of 3H dihydrotestosterone, concentration and retention of radioactivity occur in nuclei of certain neurons in the spinal cord and spinal ganglia as well as in dorsal and ventral root cells of chick embryos at day 10, 12, and 18. Cell of the glycogen body show nuclear labeling at day 12, but not at day ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236561
更新日期：1981-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2706-z
更新日期：2011-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237486
更新日期：1986-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00608257
更新日期：1990-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1595-2
更新日期：2009-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210100832
更新日期：2001-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1330-z
更新日期：2008-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-012-3369-0
更新日期：2013-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050453
更新日期：1998-07-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-2194-5
更新日期：2005-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228412
更新日期：1994-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227964
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-011-2878-6
更新日期：2012-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237178
更新日期：1982-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00228901
更新日期：1989-01-01 00:00:00
abstract：:Optokinetic circular vection (CV) was investigated in 12 subjects using an optokinetic pattern rotating at 15 degrees /s, 30 degrees /s, or 60 degrees /s, and four viewing conditions: FOL, subjects attentively followed details of pattern; STA, subjects stared at the pattern; SUP, subjects suppressed their optokinetic ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1104-y
更新日期：2002-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1038-4
更新日期：2002-05-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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journal_title：Experimental brain research
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pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2009-07-01 00:00:00
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更新日期：2000-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5026-0
更新日期：2017-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2018-11-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247369
更新日期：1989-01-01 00:00:00
