Abstract:
:The amyloid precursor protein (APP) is one of the key proteins in Alzheimer's disease (AD), as it is the precursor of amyloid β (Aβ) peptides accumulating in amyloid plaques. The processing of APP and the pathogenic features of especially Aβ oligomers have been analyzed in detail. Remarkably, there is accumulating evidence from cell biological and structural studies suggesting that APP and its mammalian homologs, the amyloid precursor-like proteins (APLP1 and APLP2), participate under physiological conditions via trans-cellular dimerization in synaptogenesis. This offers the possibility that loss of synapses in AD might be partially explained by dysfunction of APP/APLPs cell adhesion properties. In this review, structural characteristics of APP trans-cellular interaction will be placed critically in context with its putative physiological functions focusing on cell adhesion and synaptogenesis.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Baumkötter F,Wagner K,Eggert S,Wild K,Kins Sdoi
10.1007/s00221-011-2878-6subject
Has Abstractpub_date
2012-04-01 00:00:00pages
389-95issue
3-4eissn
0014-4819issn
1432-1106journal_volume
217pub_type
杂志文章,评审abstract::In studies of human eye-head coordinated saccadic gaze shifts, different laboratories have found greatly different magnitudes of head movements for a given amplitude of gaze shift (head movement gain). The present study was conducted to examine why, and to quantify volitional head movements. Fixation/target lights wer...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230391
更新日期:1992-01-01 00:00:00
abstract::Rats probe objects with their whiskers and make decisions about sizes, shapes, textures and distances within a few tens of milliseconds. This perceptual analysis requires the processing of tactile high-frequency object components reflecting surface roughness. We have shown that neurons in the barrel cortex of rats enc...
journal_title:Experimental brain research
pub_type: 杂志文章
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abstract::Dorsomedial frontal cortex (DMFC) was studied in monkeys trained to make visually guided eye or arm movements. Portions of DMFC are involved in the execution of learned, goal-directed behaviors. Many neurons discharge with both eye and hand movements as well as when motor responses are withheld, provided these behavio...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247300
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235821
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abstract::The afferent and efferent projections of the lobulus petrosus (LP) of the paraflocculus were examined by retrograde tracing with cholera toxin subunit B (CTB) and anterograde tracing with CTB or biotinylated dextran (BD) in the macaque. Following injections of the tracers into the LP, labeled neurons were seen mainly ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1241-3
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abstract::Recent morphological observations have suggested neurotransmitter specific degeneration of amongst others, the serotonergic system in the aged rat brain. However, morphological studies can only give a static picture of the events that take place over a period of several months. In the present study we used an experime...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230689
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abstract::Theta burst stimulation (TBS) is a special repetitive transcranial magnetic stimulation (rTMS) paradigm, where bursts of low-intensity stimuli are applied in the theta frequency. The aim of this study was to investigate the effect of neuronavigated TBS over primary somatosensory cortex (SI) on laser-evoked potentials ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1188-5
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2769-x
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237270
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002210050257
更新日期:1998-01-01 00:00:00
abstract::Previous work in our laboratory has demonstrated that binocular vision makes an important contribution to skilled reaching and grasping movements directed at static targets. In the present study we examine the contribution of binocular vision to interceptive reaching movements. We monitored such movements using a high...
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
doi:10.1007/s002210050323
更新日期:1998-03-01 00:00:00
abstract::Two versions of the hypothesis that discrete movements are produced by shifts in the system's equilibrium point are considered. The first suggests that shifts are monotonic and end near the peak velocity of movement, and the second presumes that they are nonmonotonic ("N-shaped") and proceed until the end of movement....
journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00241503
更新日期:1995-01-01 00:00:00
abstract::Single cell activity was recorded from the putamen in rhesus monkeys (Macaca mulatta) performing limb movements made both with and without a preceding preparatory "set" concerning the impending direction of movement. The monkeys were trained to perform an elbow step-tracking task, each trial of which required the subj...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00247293
更新日期:1987-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238096
更新日期:1982-01-01 00:00:00
abstract::Many neurons in the deeper layers of the superior colliculus (SC) respond to multiple sensory inputs--visual, auditory, and somatic--as well as provide signals essential for saccadic eye movements to targets in different modalities. When the eyes and pinnae are in primary position, the neural map of auditory space is ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231709
更新日期:1995-01-01 00:00:00
abstract::In humans, studies of back muscle activity have mainly addressed the functioning of lumbar muscles during postural adjustments or rhythmic activity, including locomotor tasks. The present study investigated how back muscles are activated along the spine during rhythmical activities in order to gain insights into spina...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-007-1146-2
更新日期:2008-02-01 00:00:00
abstract::Lightly touching a stable reference is associated with sway reduction during standing. Unexpected displacement of the touch reference results in a false-positive balance reaction in some participants, but only with the first such disturbance. This study investigated whether light touch reduces standing sway (1) after ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5455-4
更新日期:2019-03-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227241
更新日期:1992-01-01 00:00:00
abstract::The insula is a region that integrates interoception and drug urges, but little is known about its role in behavioral addiction such as internet addiction. We investigated insula-based functional connectivity in participants with internet gaming disorder (IGD) and healthy controls (HC) using resting-state functional M...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-016-4659-8
更新日期:2016-09-01 00:00:00
abstract::A total of ten alpha motor axons which innervated the peroneus brevis muscle were isolated in two cynomolgus monkeys. In each experiment, the isolated alpha axons were stimulated collectively to deplete glycogen from their muscle units. The muscle was then frozen quickly , cut serially, and stained for glycogen. Of th...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237175
更新日期:1982-01-01 00:00:00
abstract::In order to determine the responses of paraventricular nucleus neurones following activation of central serotonergic pathways, single unit activity was recorded and responses following electrical stimulation of the midbrain dorsal raphe nucleus were examined. Excitation was recorded from approximately 50% of the cells...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228913
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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doi:10.1007/s00221-009-1955-6
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228123
更新日期:1990-01-01 00:00:00
abstract::Extracellular single-unit recordings were made during day- and night-time in the pineal gland of urethane-anesthetized adult male Sprague-Dawley rats. All cells exhibiting spontaneous electrical activity had firing frequencies from less than 1 Hz to about 100 Hz, and their discharge patterns were characterized as regu...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235276
更新日期:1984-01-01 00:00:00
abstract::The purpose of this study was to investigate the temporal relationship between presaccadic neuronal discharges in the frontal eye fields (FEF) and supplementary eye fields (SEF) and the initiation of saccadic eye movements in macaque. We utilized an analytical technique that could reliably identify periods of neuronal...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00241967
更新日期:1995-01-01 00:00:00
abstract::Ocular responses to optokinetic stimulation were reexamined in adult albino rats of two different strains. Eye movements were measured in head-restrained animals using the search coil method. In contrast to some previous results, the albino rats showed optokinetic nystagmus, and some of them made responses comparable ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235639
更新日期:1985-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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pub_type: 杂志文章
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