An associativity requirement for locus coeruleus-induced long-term potentiation in the dentate gyrus of the urethane-anesthetized rat.

Abstract:

:Norepinephrine has been hypothesized to provide a learning and memory signal. Norepinephrine long-term potentiation of perforant path input to the dentate gyrus of the hippocampus provides a model for norepinephrine initiated memory processes. However, in vitro, the pairing of perforant path stimulation and norepinephrine is not required for the occurrence of norepinephrine-dependent long-term potentiation. Since bath application of norepinephrine induces long-term changes in 2nd messenger signalling and differs in a number of ways from physiological norepinephrine release, the present study is an in vivo test of the associative requirement for the pairing of perforant path input with norepinephrine to induce long-term potentiation. Phasic activation of the locus coeruleus is provided by glutamate infusion into the locus coeruleus to initiate transient norepinephrine release in the hippocampus of urethane-anesthetized Sprague-Dawley rats. Perforant path stimulation (0.067 Hz) was given throughout the experiment in the paired condition. In the unpaired condition perforant path stimulation was interrupted 10 min prior to locus coeruleus activation and resumed 10 min after locus coeruleus activation. Locus coeruleus-induced long-term potentiation of both EPSP slope and population spike only occurred in the pairing condition. This result argues that, in vivo, temporal proximity of locus coeruleus-associated norepinephrine release and perforant path stimulation are required to induce long-term plasticity. The associativity requirement for locus coeruleus activation and perforant path stimulation in vivo is consistent with the hypothesis that norepinephrine can initiate circuit changes supporting learning and memory.

journal_name

Exp Brain Res

authors

Reid AT,Harley CW

doi

10.1007/s00221-009-1955-6

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

151-9

issue

2

eissn

0014-4819

issn

1432-1106

journal_volume

200

pub_type

杂志文章
  • Subcortical projections of the dorsomedial visual area (DM) of visual association cortex in the owl monkey, Aotus trivirgatus.

    abstract::The efferent subcortical connections of the dorsomedial cortical visual area (DM) in the owl monkey were determined by tracing degenerating axons following lesions or by tracing axonal pathways following injection of radioactively labeled proline. Areas of termination included structures which are known to receive inp...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238705

    authors: Norden JJ,Lin CS,Kaas JH

    更新日期:1978-07-14 00:00:00

  • Multi-sensory integration of spatio-temporal segmentation cues: one plus one does not always equal two.

    abstract::How are multiple, multi-sensory stimuli combined for use in segmenting spatio-temporal events? For an answer, we measured the effect of various auditory or visual stimuli, in isolation or in combination, on a bistable percept of visual motion ("bouncing" vs. "streaming"). To minimize individual differences, the physic...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-007-0897-0

    authors: Zhou F,Wong V,Sekuler R

    更新日期:2007-07-01 00:00:00

  • Early manifestation of arm-leg coordination during stepping on a surface in human neonates.

    abstract::The accomplishment of mature locomotor movements relies upon the integrated coordination of the lower and upper limbs and the trunk. Human adults normally swing their arms and a quadrupedal limb coordination persists during bipedal walking despite a strong corticospinal control of the upper extremities that allows to ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-018-5201-y

    authors: La Scaleia V,Ivanenko Y,Fabiano A,Sylos-Labini F,Cappellini G,Picone S,Paolillo P,Di Paolo A,Lacquaniti F

    更新日期:2018-04-01 00:00:00

  • Bimanual co-ordination in Huntington's disease.

    abstract::The ability of Huntington's disease patients to co-ordinate their two hands with and without external cueing was investigated. Twelve Huntington's disease patients and sex- and age-matched controls performed a bimanual cranking task at two speeds (0.5 Hz, 1.5 Hz) and phase relationships (in-phase, anti-phase), with an...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000485

    authors: Johnson KA,Bennett JE,Georgiou N,Bradshaw JL,Chiu E,Cunnington R,Iansek R

    更新日期:2000-10-01 00:00:00

  • Postural reorganization of weight-shifting in below-knee amputees during leg raising.

    abstract::The position of the center of gravity (CG) is a reference value that is controlled by the nervous system during the performance of movements. In order to maintain equilibrium, leg movement is preceded by a shift of the CG towards the supporting side. This CG shift is initiated by an early displacement of the center of...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050453

    authors: Mouchnino L,Mille ML,Cincera M,Bardot A,Delarque A,Pedotti A,Massion J

    更新日期:1998-07-01 00:00:00

  • Postural adjustments in arm and leg muscles associated with isodirectional and antidirectional coupling of upper limb movements in the horizontal plane.

    abstract::The hypothesis that anticipatory postural adjustments (APAs) may concur in generating the directional preference experienced during limb coupled movements was tested by measuring the electromyographic and mechanic postural actions elicited when moving: (1) one single arm/hand and, (2) both limbs, iso- or antidirection...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-008-1470-1

    authors: Baldissera F,Rota V,Esposti R

    更新日期:2008-09-01 00:00:00

  • Intensity dependent effect of cognitive training on motor cortical plasticity and cognitive performance in humans.

    abstract::Intervention-induced neuroplastic changes within the motor or cognitive system have been shown in the human brain. While cognitive and motor brain areas are densely interconnected, it is unclear whether this interconnectivity allows for a shared susceptibility to neuroplastic changes. Using the preparation for a theor...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-020-05933-5

    authors: Berns C,Brüchle W,Scho S,Schneefeld J,Schneider U,Rosenkranz K

    更新日期:2020-12-01 00:00:00

  • Increased leg muscle fatigability during 2 mA and 4 mA transcranial direct current stimulation over the left motor cortex.

    abstract::Transcranial direct current stimulation (tDCS) using intensities ≤ 2 mA on physical and cognitive outcomes has been extensively investigated. Studies comparing the effects of different intensities of tDCS have yielded mixed results and little is known about how higher intensities (> 2 mA) affect outcomes. This study e...

    journal_title:Experimental brain research

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00221-019-05721-w

    authors: Workman CD,Kamholz J,Rudroff T

    更新日期:2020-02-01 00:00:00

  • The response variability of striate cortical neurons in the behaving monkey.

    abstract::In order to relate single cell performance to behavioral discrimination one needs measurements of the response variance of the units. We recorded from 183 single units of area V1 of monkeys performing an orientation discrimination task. The response variance was found to increase with increasing response strength. Thi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00275002

    authors: Vogels R,Spileers W,Orban GA

    更新日期:1989-01-01 00:00:00

  • Atrophy and loss of dopaminergic mesencephalic neurons in heterozygous weaver mice.

    abstract::The phenotypic effect of the weaver mutation in the ventral midbrain of homozygous mutants is associated with the progressive loss of dopaminergic neurons. To discover whether the number of mesencephalic dopaminergic cells is altered in weaver heterozygotes (wv/+), we studied mice between 20 and 365 days of age. We co...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF02454137

    authors: Verina T,Norton JA,Sorbel JJ,Triarhou LC,Laferty D,Richter JA,Simon JR,Ghetti B

    更新日期:1997-01-01 00:00:00

  • Automatic postural responses in the cat: responses of distal hindlimb muscles to paired vertical perturbations of stance.

    abstract::The active components of the quadrupedal diagonal stance response to rapid removal of the support from beneath a single limb were studied in cats to further define the mechanisms that trigger and generate the response. We recorded EMG activity from lateral gastrocnemius and tibialis anterior muscles in awake, behaving...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00249792

    authors: Rushmer DS,Dunbar DC,Russell CJ,Windus SL

    更新日期:1987-01-01 00:00:00

  • Recordings of polymodal single c-fiber nociceptive afferents following mechanical and argon-laser heat stimulation of human skin.

    abstract::Recordings were made in the peroneal nerve of healthy volunteer subjects from C-mechano-heat (CMH) nociceptors (n=25) with their receptive fields in the skin on the dorsum of the foot. The investigation focused on afferent single C-fiber activity induced by short (200 ms) high-intensity argon-laser light pulses projec...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002210050489

    authors: Olausson B

    更新日期:1998-09-01 00:00:00

  • Androgen target cells in spinal cord, spinal ganglia, and glycogen body of chick embryos. Autoradiographic localization.

    abstract::After injection of 3H dihydrotestosterone, concentration and retention of radioactivity occur in nuclei of certain neurons in the spinal cord and spinal ganglia as well as in dorsal and ventral root cells of chick embryos at day 10, 12, and 18. Cell of the glycogen body show nuclear labeling at day 12, but not at day ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00236561

    authors: Reid FA,Gasc JM,Stumpf WE,Sar M

    更新日期:1981-01-01 00:00:00

  • Neural compensation for mechanical loading of the hand during coupled oscillations of the hand and foot.

    abstract::The role of kinaesthetic afferences in controlling coupling of voluntary oscillation of the hand and foot, both in-phase and anti-phase, was investigated by modifying the mechanical properties of one of the two segments (the hand) with applied inertial or elastic loads. Loads consisted of a lead disk, rotating coaxial...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210100762

    authors: Baldissera F,Cavallari P

    更新日期:2001-07-01 00:00:00

  • Slow and steady is not as easy as it sounds: interlimb coordination at slow speed is associated with elevated attentional demand especially in older adults.

    abstract::The present study investigated age-related changes in the attentional demands associated with interlimb coordination involving upper and lower limbs performed at three different movement frequencies. Younger and older adults performed rhythmical, 180° out-of-phase flexion-extension movements of the knee and elbow with...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-013-3511-7

    authors: Fujiyama H,Hinder MR,Garry MI,Summers JJ

    更新日期:2013-06-01 00:00:00

  • Chemically, mechanically, and hyperosmolarity-induced calcium responses of rat cortical capillary endothelial cells in culture.

    abstract::The purpose of the present work was to characterize calcium responses of brain-capillary endothelial cells (BCEC), the cells forming the blood-brain barrier, to chemical, hyperosmolar and mechanical stimulation. Confluent BCEC cultures were grown from capillary fragments isolated from rat cerebral cortex. Intracellula...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210050755

    authors: Paemeleire K,de Hemptinne A,Leybaert L

    更新日期:1999-06-01 00:00:00

  • Differences between Han Chinese and Caucasians in transcranial magnetic stimulation parameters.

    abstract::The study was conducted to investigate the difference between Han Chinese and Caucasians on various parameters measured from responses to transcranial magnetic brain stimulation (TMS). Sixteen subjects were studied in each group. A circular coil at the vertex was used for stimulation, whilst recording surface electrom...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-013-3763-2

    authors: Yi X,Fisher KM,Lai M,Mansoor K,Bicker R,Baker SN

    更新日期:2014-02-01 00:00:00

  • Changes in corticospinal motor excitability induced by non-motor linguistic tasks.

    abstract::The excitability of the corticospinal motor pathways to transcranial magnetic stimulation (TMS) can be differentially modulated by a variety of motor tasks. However, there is emerging evidence that linguistic tasks may alter excitability of the corticospinal motor pathways also. In this study we evaluated the effect o...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-003-1648-5

    authors: Papathanasiou I,Filipović SR,Whurr R,Rothwell JC,Jahanshahi M

    更新日期:2004-01-01 00:00:00

  • Activating memories of depression alters the experience of voluntary action.

    abstract::The sense of agency is a profoundly important human experience and is strongly linked to volitional action. The importance of this experience is underscored by the fact that many neurological and psychiatric disorders are partially characterized by an abnormal sense of agency (e.g., schizophrenia, anxiety disorders, d...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-012-3372-5

    authors: Obhi SS,Swiderski KM,Farquhar R

    更新日期:2013-09-01 00:00:00

  • Repeated optokinetic stimulation in conditions of active standing facilitates recovery from vestibular deficits.

    abstract::Successful results obtained by training sessions using optokinetic (OK) stimulations in order to rehabilitate patients with balance disorders motivated this study. The purpose of the study was to measure eye movement parameters and body stabilization during OK stimulation before and after the rehabilitation program. T...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00232446

    authors: Vitte E,Sémont A,Berthoz A

    更新日期:1994-01-01 00:00:00

  • The mirror antisaccade task: direction-amplitude interaction and spatial accuracy characteristics.

    abstract::In this study we examined the performance of human subjects in three oculomotor tasks: a visually guided saccade task (VST), a simple antisaccade task (SAT) and a mirror antisaccade task (MAT). The stimulus presentation was identical for all three tasks, and the differentiation of the tasks was based on the instructio...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-006-0462-2

    authors: Evdokimidis I,Tsekou H,Smyrnis N

    更新日期:2006-09-01 00:00:00

  • Differentiation between the contributions of shortening reaction and stretch-induced inhibition to rigidity in Parkinson's disease.

    abstract::Parkinsonian rigidity is characterized by an increased resistance of a joint to externally imposed motion that remains uniform with changing joint angle. Two candidate mechanisms are proposed for the uniformity of rigidity, involving neural-mediated excitation of shortening muscles, i.e., shortening reaction (SR), or ...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2594-2

    authors: Xia R,Powell D,Rymer WZ,Hanson N,Fang X,Threlkeld AJ

    更新日期:2011-04-01 00:00:00

  • Relationship between input and output of cells in motor and somatosensory cortices of the chronic awake rat. A study using glass micropipettes.

    abstract::Experiments using the same glass microelectrode (6--8 M omega) for recording and stimulating were performed on 12 rats in which 379 cortical cells were studied in 65 penetrations through the motor and somatosensory cortical zones. To avoid anaesthetic effects the rats were chronically implanted with a head system deri...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/BF00238808

    authors: Sapienza S,Talbi B,Jacquemin J,Albe-Fessard D

    更新日期:1981-01-01 00:00:00

  • Grasping isoluminant stimuli.

    abstract::We used a virtual reality setup to let participants grasp discs, which differed in luminance, chromaticity and size. Current theories on perception and action propose a division of labor in the brain into a color proficient perception pathway and a less color-capable action pathway. In this study, we addressed the que...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-009-1841-2

    authors: Kleinholdermann U,Franz VH,Gegenfurtner KR,Stockmeier K

    更新日期:2009-07-01 00:00:00

  • Relationship between motor activity-related cortical potential and voluntary muscle activation.

    abstract::The purpose of this study was to investigate the relationship between EEG-derived motor activity-related cortical potential (MRCP) and voluntary muscle activation. Eight healthy volunteers participated in two experimental sessions. In one session, subjects performed isometric elbow-flexion contractions at four intensi...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s002210000382

    authors: Siemionow V,Yue GH,Ranganathan VK,Liu JZ,Sahgal V

    更新日期:2000-08-01 00:00:00

  • Human vestibular perceptual thresholds for pitch tilt are slightly worse than for roll tilt across a range of frequencies.

    abstract::Vestibular perceptual thresholds measure vestibular sensory and perceptual noise by quantifying how small of a passive self-motion an individual is able to reliably perceive. Vestibular thresholds have clinical and operational relevance, as they are elevated in vestibular migraine patients, and even healthy individual...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-020-05830-x

    authors: Suri K,Clark TK

    更新日期:2020-06-01 00:00:00

  • Grasping and hitting moving objects.

    abstract::Some experimental evidence suggests that grasping should be regarded as independent control of the thumb and the index finger (digit control hypothesis). To investigate this further, we compared how the tips of the thumb and the index finger moved in space when grasping spheres to how they moved when they were hitting...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-011-2756-2

    authors: Schot WD,Brenner E,Smeets JB

    更新日期:2011-08-01 00:00:00

  • The finishing touches: the role of friction and roughness in haptic perception of surface coatings.

    abstract::Humans are extraordinarily skilled in the tactile evaluation of, and differentiation between, surfaces. The chemical and mechanical properties of these surfaces are translated into tactile signals during haptic exploration by mechanoreceptors in our skin, which are specialized to respond to different types of temporal...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-020-05831-w

    authors: Skedung L,Harris KL,Collier ES,Rutland MW

    更新日期:2020-06-01 00:00:00

  • Stabilization of posture by precision touch of the index finger with rigid and flexible filaments.

    abstract::Light touch of the index finger with a stationary surface at non-mechanically supportive force levels (<100 g) greatly attenuates the body sway of standing subjects. In three experiments, we evaluated the properties of finger contact and of the contacted object necessary to produce postural stabilization in subjects s...

    journal_title:Experimental brain research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s002210100775

    authors: Lackner JR,Rabin E,DiZio P

    更新日期:2001-08-01 00:00:00

  • Suppressive musculocutaneous reflexes in tibialis anterior following upper leg stimulation at the end of the swing phase.

    abstract::In the cat it is known that the distribution and modulation of the so-called P2 responses are similar, irrespective of whether they are obtained with electrodes implanted in the different skin areas or in the various leg muscles. In man it is known that the specific stimulation of cutaneous afferents from different pa...

    journal_title:Experimental brain research

    pub_type: 杂志文章

    doi:10.1007/s00221-002-1366-4

    authors: Van de Crommert HW,Steijvers PJ,Mulder T,Duysens J

    更新日期:2003-04-01 00:00:00