Abstract：
:The phenotypic effect of the weaver mutation in the ventral midbrain of homozygous mutants is associated with the progressive loss of dopaminergic neurons. To discover whether the number of mesencephalic dopaminergic cells is altered in weaver heterozygotes (wv/+), we studied mice between 20 and 365 days of age. We counted tyrosine hydroxylase (TH)-immunopositive cells in the substantia nigra (SN), retrorubral nucleus (RRN), and ventral tegmental area (VTA), and measured cross-sectional areas of neuronal somata in the SN of wv/+ and age-matched wild-type controls (+/+). The number of TH-positive cells in the wv/+ ventral midbrain was on average 13% lower than normal. Cell loss was detected selectively in the SN (12%) and VTA (23%). The areas of somatic profiles in the wv/+ nigral neurons were on average reduced by 9.8%. The neuronal losses in the SN and VTA correlated with a 13.8% reduction in dopamine level in the ventral striatum in wv/+ mice at 14-16 months of age. Our findings imply that a single dose of the weaver gene in the mouse is associated with cellular damage leading to a chronic deficiency in the mesostriatal dopaminergic system.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Verina T,Norton JA,Sorbel JJ,Triarhou LC,Laferty D,Richter JA,Simon JR,Ghetti Bdoi
10.1007/BF02454137subject
Has Abstractpub_date
1997-01-01 00:00:00pages
5-12issue
1eissn
0014-4819issn
1432-1106journal_volume
113pub_type
杂志文章abstract：:The postnatal development of monoamine levels and receptors in the occipital cortex of the cat has been investigated using neurochemical techniques. The endogenous catecholamines (noradrenaline and dopamine) gradually increased with age, displaying an about 12-13-fold increase in their concentration from the newborn t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239212
更新日期：1983-01-01 00:00:00
abstract：:The present study characterizes expression of calbindin D28K (CB-D28K) and parvalbumin (PV) in ventral forebrain (VFB) grafts placed in the neocortex of adult rats bearing quisqualic acid lesions to the nucleus basalis magnocellularis. Three to nine months after transplantation surgery, rats were killed for in situ hy...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050311
更新日期：1998-02-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235825
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050886
更新日期：1999-11-01 00:00:00
abstract：:The adaptation and habituation characteristics produced by the repeated presentation of a moving visual stimulus were studied in single cells in the pigeon's optic tectum. Units located near the surface in the stratum opticum showed little adaptation. However, cells located in deeper layers exhibited varying rates and...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235509
更新日期：1977-03-30 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1566-7
更新日期：2009-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00236234
更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-1854-x
更新日期：2009-07-01 00:00:00
abstract：:This study addresses the question as to the nature of the information on which the preactivation of the appropriate muscles in the grasping of the ball in a one-handed catching task is initiated and coordinated. High speed film and electromyograms were recorded while experiences subjects (N = 4) caught balls--projecte...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00229019
更新日期：1992-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248508
更新日期：1988-01-01 00:00:00
abstract：:Accurate information about gaze direction is required to direct the hand towards visual objects in the environment. In the present experiments, we tested whether retinal inputs affect the accuracy with which healthy subjects indicate their gaze direction with the unseen index finger after voluntary saccadic eye moveme...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1029-5
更新日期：2002-06-01 00:00:00
abstract：:A compensatory stepping response (CSR) is a common strategy to restore dynamic stability in response to a postural disturbance. Currently, few studies have investigated the CSR to laterally directed disturbances delivered to subjects during quiet standing. The purpose of this study was to characterize the CSR of young...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2854-1
更新日期：2011-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-008-1662-8
更新日期：2009-03-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-006-0743-9
更新日期：2007-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-018-5205-7
更新日期：2018-04-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2844-3
更新日期：2011-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/pl00005663
更新日期：1997-05-01 00:00:00
abstract：:Previous research has demonstrated that negative affect influences attentional processes. Here, we investigate whether pre-experimental negative affect predicts a hypervigilant neural response as indicated by increased event-related potential amplitudes in response to neutral and positive visual stimuli. In our study,...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4544-x
更新日期：2016-06-01 00:00:00
abstract：:Many vertebrates generate blinks as a component of saccadic gaze shifts. We investigated the nature of this linkage between saccades and blinking in normal humans. Activation of the orbicularis oculi, the lid closing muscle, EMG occurred with 97% of saccadic gaze shifts larger than 33 degrees. The blinks typically beg...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227203
更新日期：1994-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050574
更新日期：1998-12-01 00:00:00
abstract：:The companion article (Sholomenko et al. 1991) described the brainstem locomoter regions in the bird where direct intracerebral injection of a number of putative excitatory neurochemicals, including cholinergic agonists, N-methyl-d-aspartate (NMDA) and Substance P, evoke locomotion. Using the same experimental protoco...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00231753
更新日期：1991-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00242177
更新日期：1995-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239148
更新日期：1979-02-15 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2014-06-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
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更新日期：2000-04-01 00:00:00
abstract：:Tactile motion perception is one of the most important functions for realizing a delicate appreciation of the tactile world. To explore the neural dynamics of motion processing in the brain, the motion adaptation phenomenon can be a useful probe. Tactile motion aftereffects (MAE), however, have not been reported in a ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-0979-z
更新日期：2007-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
abstract：:Evidence suggests that there are positive effects of exercise on learning and memory. Moreover, some studies have demonstrated that forced exercise plays the role of a stressor. This study was aimed at investigating the effects of different timing of exercise and exercise withdrawal on memory, and serum and hippocampa...
journal_title：Experimental brain research
pub_type： 杂志文章
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