Abstract：
:Recent morphological observations have suggested neurotransmitter specific degeneration of amongst others, the serotonergic system in the aged rat brain. However, morphological studies can only give a static picture of the events that take place over a period of several months. In the present study we used an experimental model in which degeneration of the serotonergic system in the young adult rat brain was produced on a short time scale. Morphological changes were studied 2 h and 1 or 14 days after intracerebroventricular injection of 5,7-dihydroxytryptamine (5,7-DHT). Non-specific damage and severe depletion of serotonergic fibers was observed in the immediate surroundings of the injection site, representing the effects of high local concentrations of 5,7-DHT. Sometime after injection swollen varicosities and dilated non-varicose fibers were observed. Fourteen days after the 5,7-DHT treatment cluster-like fibers appeared. It is argued that these swollen and crumpled fiber knots are slowly degenerating fibers. A comparison is made with the abnormal serotonergic fibers in the aged rat brain and it is concluded that these aged abnormal fibers represent axonal degeneration of the serotonergic system in the senescent rat brain.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
van Luijtelaar MG,Steinbusch HW,Tonnaer JAdoi
10.1007/BF00230689subject
Has Abstractpub_date
1989-01-01 00:00:00pages
81-9issue
1eissn
0014-4819issn
1432-1106journal_volume
78pub_type
杂志文章abstract：:Extracellular focal synaptic potentials (FSPs) were recorded in forelimb segments of cats in the region where corticospinal volleys (pyramidal stimulation) gave a maximal FSP. No FSP was recorded in this region on stimulation of the medial part of the lateral reticular nucleus (LRN), provided that ventral spinal pathw...
journal_title：Experimental brain research
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