Abstract：
:Middle cerebral artery occlusion (MCAO) models have become well established as the most suitable way to simulate stroke in experimental studies. The high variability in the size of the resulting infarct due to filament composition, rodent strain and vessel anatomy makes the setup of such models very complex. Beside controllable variables of homeostasis, the choice of anesthetics and the grade of ischemia and reperfusion played a major role for extent of neurological injury. Transient MCAO was induced during either isoflurane or ketamine/xylazine (ket/xyl) anesthesia with simultaneously measurement of cerebral blood flow (CBF) in 60 male Wistar rats (380-420 g). Neurological injury was quantified after 24 h. Isoflurane compared with ket/xyl improved mortality 24 h after MCAO (10 vs. 50 %, p = 0.037) and predominantly led to striatal infarcts (78 vs. 18 %, p = 0.009) without involvement of the neocortex and medial caudoputamen. Independent of anesthesia type, cortical infarcts could be predicted with a sensitivity of 67 % and a specificity of 100 % if CBF did not exceed 35 % of the baseline value during ischemia. In all other cases, cortical infarcts developed if the reperfusion values remained below 50 %. Hyperemia during reperfusion significantly increased infarct and edema volumes. The cause of frequent striatal infarcts after isoflurane anesthesia might be attributed to an improved CBF during ischemia (46 ± 15 % vs. 35 ± 19 %, p = 0.04). S-100β release, edema volume and upregulation of IL-6 and IL-1β expression were impeded by isoflurane. Thus, anesthetic management as well as the grade of ischemia and reperfusion after transient MCAO demonstrated important effects on neurological injury.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Bleilevens C,Roehl AB,Goetzenich A,Zoremba N,Kipp M,Dang J,Tolba R,Rossaint R,Hein Mdoi
10.1007/s00221-012-3296-0subject
Has Abstractpub_date
2013-01-01 00:00:00pages
155-64issue
2eissn
0014-4819issn
1432-1106journal_volume
224pub_type
杂志文章,随机对照试验abstract：:We measured the amount of information transmitted by the direction of two-dimensional (2-D) arm movements of human subjects, and by neuronal populations in the motor cortex and area 5 of monkeys. We also compared the information transmitted by a motor cortical population when the predictability of the direction of mov...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247577
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更新日期：2007-04-01 00:00:00
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更新日期：2012-02-01 00:00:00
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