Abstract：
:Seizure susceptibility waxes and wanes in an apparently circadian manner in many epileptic patients. Fluctuations of melatonin concentration with highest levels during the night and lowest levels in the early morning could be involved in this phenomenon. Therefore, the action of melatonin on epileptic activity was tested. The experiments were carried out on human temporal neocortical slices cut from tissue resected for surgical treatment of epilepsy. Autoradiographic studies were performed on parallel slices with 100-120 pmol 2-[125I]iodomelatonin/l in the absence or presence of unlabelled melatonin. High-affinity binding sites of melatonin could be demonstrated in layers II-V of the temporal cortex. The binding was saturable, specific and occurred with low capacity. In electrophysiological studies, epileptiform field potentials were elicited by omission of Mg2+ from the superfusate and recorded from layers II-V. The frequency of occurrence of epileptiform field potentials was reduced to 0.5 of the initial value with application of melatonin (10 and 100 nmol/l) in each case. This effect was reversible upon washing. The findings favour the hypothesis that melatonin depresses epileptiform neuronal activity through specific neocortical receptors.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Fauteck JD,Bockmann J,Böckers TM,Wittkowski W,Köhling R,Lücke A,Straub H,Speckmann EJ,Tuxhorn I,Wolf Pdoi
10.1007/BF00230052subject
Has Abstract,Author List Incompletepub_date
1995-01-01 00:00:00pages
321-5issue
2eissn
0014-4819issn
1432-1106journal_volume
107pub_type
杂志文章abstract：:The 2-deoxyglucose (2-DG) autoradiographic technique was used to map functional activity in the central auditory system of the mongolian gerbil, throughout the period of functional onset. Uptake of 2-DG during exposure to 105 dB SPL wide band noise (WBN) was compared to silence in adults and in neonates at 12, 14, 16 ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239360
更新日期：1982-01-01 00:00:00
abstract：:The luminance detectors in the olivary pretectal nucleus, which are likely candidates mediating the pupillary light reflex, responded to all frequencies of sinusoidally modulated light up to 12-25 Hz. At low frequencies (0.05-4.0 Hz) the luminance detectors responded with modulated firing to different stimulation rate...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00237669
更新日期：1985-01-01 00:00:00
abstract：:The ensemble properties of unit activity in the rat hippocampus were studied during different behavioral states defined by the presence or absence of the theta rhythm. A 24-channel microelectrode was used to monitor the parallel activity of several single neurons simultaneously. Individual units were characterized by ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00239532
更新日期：1986-01-01 00:00:00
abstract：:Objective attempts to characterize postural control in subjects with cerebellar (Cb) pathology have focused primarily on sagittal plane responses to static standing, semi-dynamic standing, and platform perturbation. Repeated, dynamic, functional movement may provide a better opportunity to study the effects of ataxia ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002219900291
更新日期：2000-05-01 00:00:00
abstract：:The relations among spatial memory, Stroop-like colour-word subtests, and errors on antisaccade and memory-guided saccadic eye-movement trials for older and younger adults were tested. Two types of errors in the antisaccade task were identified: short latency prosaccade errors that were immediately corrected and longe...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-011-2921-7
更新日期：2012-01-01 00:00:00
abstract：:Optokinetic circular vection (CV) was investigated in 12 subjects using an optokinetic pattern rotating at 15 degrees /s, 30 degrees /s, or 60 degrees /s, and four viewing conditions: FOL, subjects attentively followed details of pattern; STA, subjects stared at the pattern; SUP, subjects suppressed their optokinetic ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1104-y
更新日期：2002-06-01 00:00:00
abstract：:Activities of 53 neurons in the brain stem were recorded with chronically implanted fine wires in freely eating and drinking rats. Twenty units were isolated from the trigeminal mesencephalic nucleus; 18 were spindle afferents and 2 periodontal afferents. The spindle units were classified into 4 types: 5 units showed ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247896
更新日期：1989-01-01 00:00:00
abstract：:Caloric vestibular stimulation (CVS) is a physiological technique demonstrated to transiently improve hemianaesthesia in right brain-damaged patients (Bottini et al. in Exp Brain Res 99(1):164-169, 1994, Nature 376:778-781, 1995, Neurology 65(8):1278-1283, 2005). Recent studies suggest that these effects are based on ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-010-2450-9
更新日期：2011-01-01 00:00:00
abstract：:Our understanding of how perception operates in real-world environments has been substantially advanced by studying both multisensory processes and "top-down" control processes influencing sensory processing via activity from higher-order brain areas, such as attention, memory, and expectations. As the two topics have...
journal_title：Experimental brain research
pub_type： 杂志文章,评审
doi：10.1007/s00221-016-4590-z
更新日期：2016-05-01 00:00:00
abstract：:Recent studies suggest that recreational use of cocaine is associated with significant impairments in the same cognitive control functions that are affected by chronic use. Here we tested whether recreational cocaine use can impact the emergence and resolution of response conflict in conflict-inducing tasks. Recreatio...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-013-3724-9
更新日期：2014-01-01 00:00:00
abstract：:We investigated the effect of correlation in background noise on the ability of participants to detect a kinaesthetic target on the index fingers of their hands. Participants had to judge whether the target (a smoothed ramp with quarter-sine onset and offset), was on the left or right finger (experiments 1 and 2). The...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-005-2273-2
更新日期：2005-08-01 00:00:00
abstract：:Two rhesus monkeys were trained to make saccadic eye movements from a central fixation point towards a peripheral target. Saccadic reaction times (SRTs) were measured in the gap paradigm (200 ms pause between offset of fixation point and onset of peripheral target). Target position for extensive training (SRTs of 150 ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00230109
更新日期：1990-01-01 00:00:00
abstract：:This report describes two models of human behavior when detecting displacements of joints that allow one to compare and integrate findings from different proprioception tests in a quantitative way. Results from various tests have led to different and often conflicting conclusions about proprioceptive behaviors and the...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00227954
更新日期：1996-12-01 00:00:00
abstract：:Receptive field (RF) characteristics of cells in primary visual cortex of the mouse (C57B16 strain) were studied by single unit recording. We have studied the functional organization of area 17 along both the radial and tangential dimensions of the cortex. Eighty seven percent of the visual neurons could be classified...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247312
更新日期：1988-01-01 00:00:00
abstract：:The position of the center of gravity (CG) is a reference value that is controlled by the nervous system during the performance of movements. In order to maintain equilibrium, leg movement is preceded by a shift of the CG towards the supporting side. This CG shift is initiated by an early displacement of the center of...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050453
更新日期：1998-07-01 00:00:00
abstract：:A growing body of evidence suggests that the mode of movement selection is relevant for the readiness potential, namely, internal (or free) selection of movements is associated with increased readiness potential amplitudes compared to predetermined or externally guided selection. It is little acknowledged, however, th...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-020-05878-9
更新日期：2020-10-01 00:00:00
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journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s002210050509
更新日期：1998-09-01 00:00:00
abstract：:We previously showed that proprioceptive sensory input from the hindlimbs to the anterior cerebellar cortex of the cat may not be simply organized with respect to a body map, but it may also be distributed to multiple discrete functional areas extending beyond classical body map boundaries. With passive hindlimb stepp...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-017-5067-4
更新日期：2017-11-01 00:00:00
abstract：:Our perception of the vertical depends on allocentric information about the visual surrounds, egocentric information about the own body axis and gravicentric information about the pull of gravity. Previous work has documented that some individuals rely strongly on allocentric information, while others do not, and the ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-015-4526-z
更新日期：2016-04-01 00:00:00
abstract：:A central network of neurones in the spinal cord has been shown to produce a rhythmic motor output similar to locomotion after suppression of all afferent inflow. The experiments were performed mainly in acute spinal cats (th. 12), which had received DOPA i.v. and the monoamine oxidase inhibitor Nialamide. In some pre...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00235671
更新日期：1979-01-15 00:00:00
abstract：:The coordination between eye and head movements during a rapid orienting gaze shift has been investigated mainly when subjects made horizontal movements towards visual targets with the eyes starting at the centre of the orbit. Under these conditions, it is difficult to identify the signals driving the two motor system...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
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更新日期：1997-05-01 00:00:00
abstract：:The effects on striatal high affinity glutamate uptake (HAGU) of an apomorphine injection administered either alone or along with an electrical stimulation of the frontal cortex were compared between intact control rats and animals with 6-hydroxydopamine (6-OHDA) induced lesions of the nigrostriatal dopaminergic neuro...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00247588
更新日期：1988-01-01 00:00:00
abstract：:The purpose of this study is to analyze the coordination patterns of the elevation angles of lower limb segments following the onset of unsupported walking in children and to look for the existence of a planar covariation rule as previously described in adult human locomotion. The kinematic patterns of locomotion were...
journal_title：Experimental brain research
pub_type： 临床试验,杂志文章
doi：10.1007/s002210000663
更新日期：2001-04-01 00:00:00
abstract：:Perhaps the most intriguing disorders of body representation are those that are not due to primary disease of brain tissue. Strange and sometimes painful phantom limb sensations can result from loss of afference to the brain; and Complex Regional Pain Syndrome (CRPS)-the subject of the current report-can follow limb t...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-009-2107-8
更新日期：2010-07-01 00:00:00
abstract：:The purpose of this study was to investigate whether repetitive electrical stimulation of the common peroneal nerve (CPN) is associated with changes in the motor response of the tibialis anterior (TA) muscle elicited by focal magnetic stimulation of the motor cortex. Motor evoked potentials (MEP) with a stimulation in...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-002-1094-9
更新日期：2002-08-01 00:00:00
abstract：:The primary objective of this study was to explore why preischemic hypoglycemia, which restricts tissue acidosis during the ischemic insult, does not ameliorate cell damage incurred as a result of transient ischemia. The question arose whether hypoglycemia (plasma glucose concentration 2-3 mM) delays resumption of ext...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00233036
更新日期：1995-01-01 00:00:00
abstract：:Generally, increases in cortical activity go in parallel with negative shifts and decreases with positive shifts of cortical d.c. potentials. The aim of the present investigation was to test the effects of the inhibitory transmitter gamma-aminobutyric acid (GABA) and of GABA receptor agonists on cortical d.c. potentia...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/pl00005614
更新日期：1997-03-01 00:00:00
abstract：:Interval timing deficiencies in Parkinson's disease (PD) patients have been a matter of debate. Here we test the possibility of PD heterogeneity as a source for this discrepancy. Temporal performance of PD patients and control subjects was assessed during two interval tapping tasks and during a categorization task of ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-007-1097-7
更新日期：2008-01-01 00:00:00
abstract：:The Ca++ -dependence of the repetitive firing of neostriatal neurons was studied in an in vitro slice preparation of the rat neostriatum. Neuronal firing was evoked by injecting depolarizing currents of 100-200 ms duration. In normal conditions, the mode of firing was tonic and showed very little adaptation. The frequ...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/BF00248539
更新日期：1989-01-01 00:00:00
abstract：:The aim of this study was to investigate the effect of single joint displacement on the pattern of leg muscle electromyographic (EMG) activity during locomotion. For the first time, unilateral rotational hip or knee joint displacements were applied by a driven orthotic device at three phases of swing during locomotion...
journal_title：Experimental brain research
pub_type： 杂志文章
doi：10.1007/s00221-004-1904-3
更新日期：2004-10-01 00:00:00
