Abstract：
:The purpose of this study was to determine if recovery of neurologically impaired hand function following isolated motor cortex injury would occur without constraint of the non-impaired limb, and without daily forced use of the impaired limb. Nine monkeys (Macaca mulatta) received neurosurgical lesions of various extents to arm representations of motor cortex in the hemisphere contralateral to the preferred hand. After the lesion, no physical constraints were placed on the ipsilesional arm/hand and motor testing was carried out weekly with a maximum of 40 attempts in two fine motor tasks that required use of the contralesional hand for successful food acquisition. These motor tests were the only "forced use" of the contralesional hand. We also tested regularly for spontaneous use of the contralesional hand in a fine motor task in which either hand could be used for successful performance. This minimal intervention was sufficient to induce recovery of the contralesional hand to such a functional level that eight of the monkeys chose to use that hand on some trials when either hand could be used. Percentage use of the contralesional hand (in the task when either hand could be used) varied considerably among monkeys and was not related to lesion volume or recovery of motor skill. These data demonstrate a remarkable capacity for recovery of spontaneous use of the impaired hand following localized frontal lobe lesions. Clinically, these observations underscore the importance of therapeutic intervention to inhibit the induction of the learned nonuse phenomenon after neurological injury.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Darling WG,Pizzimenti MA,Rotella DL,Hynes SM,Ge J,Stilwell-Morecraft KS,Vanadurongvan T,McNeal DW,Solon-Cline KM,Morecraft RJdoi
10.1007/s00221-010-2157-ysubject
Has Abstractpub_date
2010-05-01 00:00:00pages
529-42issue
3eissn
0014-4819issn
1432-1106journal_volume
202pub_type
杂志文章abstract：:The effects of L-DOPA, naloxone, and the opioids (D-Ala2,N-Me-Phe4,Gly5-ol)-enkephalin (DAGO) and D-Ser2-Leu-enkephalin-Thr6 (DSLET) on spinal motor rhythm generation were compared in anemically decapitated high spinal cats. After premedication with nialamide, DOPA caused the well-known, slow rhythmic motor activity w...
journal_title：Experimental brain research
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doi：10.1007/s00221-007-1184-9
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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