Abstract：
:Studies of the effects of physical activity on cognition suggest that aerobic fitness can improve cognitive abilities. However, the physiological mechanisms for the cognitive benefit of aerobic fitness are less well understood. We examined the association between aerobic fitness and cerebrovascular function with neurocognitive functions in healthy, young adults. Participants aged 18-29 years underwent measurements of cerebral vasomotor reactivity (CVMR) in response to rebreathing-induced hypercapnia, maximal oxygen uptake (VO2max) during cycle ergometry to voluntary exhaustion, and simple- and complex-neurocognitive assessments at rest. Ten subjects were identified as having low-aerobic fitness (LF < 15th fitness percentile), and twelve subjects were identified as having high-aerobic fitness (HF > 80th fitness percentile). There were no LF versus HF group differences in cerebrovascular hemodynamics during the baseline condition. Changes in middle cerebral artery blood velocity and CVMR during hypercapnia were elevated more in the HF than the LF group. Compared to the LF, the HF performed better on a complex-cognitive task assessing fluid reasoning, but not on simple attentional abilities. Statistical modeling showed that measures of VO2max, CVMR, and fluid reasoning were positively inter-correlated. The relationship between VO2max and fluid reasoning, however, did not appear to be reliably mediated by CVMR. In conclusion, a high capacity for maximal oxygen uptake among healthy, young adults was associated with greater CVMR and better fluid reasoning, implying that high-aerobic fitness may promote cerebrovascular and cognitive functioning abilities.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Hwang J,Kim K,Brothers RM,Castelli DM,Gonzalez-Lima Fdoi
10.1007/s00221-018-5230-6subject
Has Abstractpub_date
2018-05-01 00:00:00pages
1421-1430issue
5eissn
0014-4819issn
1432-1106pii
10.1007/s00221-018-5230-6journal_volume
236pub_type
杂志文章abstract：:Interval timing deficiencies in Parkinson's disease (PD) patients have been a matter of debate. Here we test the possibility of PD heterogeneity as a source for this discrepancy. Temporal performance of PD patients and control subjects was assessed during two interval tapping tasks and during a categorization task of ...
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Experimental brain research
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journal_title：Experimental brain research
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
pub_type： 杂志文章
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journal_title：Experimental brain research
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