Abstract:
:Descending vestibular pathways have been shown to influence recruitment thresholds of alpha motoneurones in both human and cat. However, whereas parallel connections to the fusimotor system have been shown in the cat, such connections have not yet been demonstrated in humans. In the present study we investigated whether vestibular inputs can influence the firing of spontaneously active muscle spindles in the leg via activation of gamma motoneurones. Unitary recordings were made from 30 muscle spindle afferents via tungsten microelectrodes inserted percutaneously into the common peroneal nerve of seated awake human subjects. Sinusoidal bipolar binaural galvanic vestibular stimulation (GVS; frequency 0.2, 0.5, 0.8 Hz, amplitude +/-2 mA, 100 cycles) was applied to the mastoid processes. This continuous stimulation produced a sustained frequency-dependent illusion of "rocking in a boat" or "swinging in a hammock". Despite these robust illusions none of the spontaneously active muscle spindles exhibited phase-locked modulation of firing during sinusoidal GVS. We conclude that this dynamic vestibular input was not sufficient to recruit gamma motoneurones, which are known to have little spontaneous activity in relaxed human muscles.
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Bent LR,Bolton PS,Macefield VGdoi
10.1007/s00221-006-0836-5subject
Has Abstractpub_date
2007-06-01 00:00:00pages
97-103issue
1eissn
0014-4819issn
1432-1106journal_volume
180pub_type
杂志文章abstract::In a previous study of the heat grill illusion, sensations of burning and stinging were sometimes reported when the skin was cooled by as little as 2 degrees C. Informal tests subsequently indicated that these nociceptive sensations were experienced if cooling occurred when the stimulating thermode rested on the skin,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-002-1280-9
更新日期:2003-02-01 00:00:00
abstract::The amyloid precursor protein (APP) is one of the key proteins in Alzheimer's disease (AD), as it is the precursor of amyloid β (Aβ) peptides accumulating in amyloid plaques. The processing of APP and the pathogenic features of especially Aβ oligomers have been analyzed in detail. Remarkably, there is accumulating evi...
journal_title:Experimental brain research
pub_type: 杂志文章,评审
doi:10.1007/s00221-011-2878-6
更新日期:2012-04-01 00:00:00
abstract::Using different tracer substances the pathways connecting the superior colliculus with the diencephalon were studied in the Madagascan hedgehog tenrec (Echinops telfairi), a nocturnal insectivore with tiny eyes, a small and little differentiated superior colliculus and a visual cortex with no obvious fourth granular l...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00228725
更新日期:1996-10-01 00:00:00
abstract::The size-weight illusion induced by visually perceived sizes was reexamined to investigate whether this illusion is a sensory based or cognitive-based phenomenon. A computer-augmented environment was utilized to manipulate visual size information of target objects independently of their haptic information. Two physica...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0803-1
更新日期:2007-05-01 00:00:00
abstract::A photograph of an action contains implicit information about the depicted motion. Previous studies using either psychophysics or neuroimaging suggested that the neural processing of implied-motion images shares some features of real-motion processing. According to the hypothesis that the target depicted in photograph...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-011-2598-y
更新日期:2011-04-01 00:00:00
abstract::Based on the observations that the psychostimulant drug amphetamine in combination with physiotherapy can promote recovery of brain function after brain injury, we have studied the ability of the vigilance promoting drug Modafinil to counteract 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-(MPTP)-induced degeneration o...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02259133
更新日期:1992-01-01 00:00:00
abstract::Deep brain stimulation of the subthalamic nucleus (STN DBS) significantly improves clinical motor symptoms, as well as intensive aspects of movement like velocity and amplitude in patients with Parkinson's disease (PD). However, the effects of bilateral STN DBS on integrative and coordinative aspects of motor control ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5197-3
更新日期:2018-04-01 00:00:00
abstract::The axonal conduction latency of brisk-sustained and brisk-transient cat retinal ganglion cells increases with proximity to the area centralis. The trend is gradual with considerable local scatter of latencies, and is similar for cells with crossed and uncrossed axons. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238731
更新日期:1975-07-11 00:00:00
abstract::Fetal spinal cord tissue was grafted to the anterior chamber of the eye of adult recipients. Transverse segments from the cervical and high thoracic levels were divided in halves which were grafted directly or further divided into ventral horn and dorsal horn parts before grafting. Survival and intraocular growth was ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237016
更新日期:1985-01-01 00:00:00
abstract::Reactive responses to balance perturbations have been shown to be improved by training. This investigation aimed to compare the effects of block and random training perturbation schedules on stability gains of compensatory arm and leg movements in response to unpredictable large-magnitude balance perturbations. Pertur...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05806-x
更新日期:2020-05-01 00:00:00
abstract::An object held in precision grip creates predictable load forces on the hand during voluntary hand movement and these are associated with anticipatory modulation of grip force. Conflicting results have been obtained over whether predictable external load perturbations result in anticipatory grip force responses (e.g. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0537-0
更新日期:2006-10-01 00:00:00
abstract::The fast-twitch flexor digitorum longus (FDL) muscle was partially denervated by a unilateral section of the L7 ventral root. After approximately 100 days the isometric, force-velocity and histochemical properties of single motor units from the partially denervated muscle were determined. The diameter of the nerve axo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236946
更新日期:1985-01-01 00:00:00
abstract::Deficits in postural control are one of the hallmarks of disability in children with cerebral palsy (CP). Yet, much remains unknown regarding the etiology of postural deficits in these children. Here we evaluated postural control at a simplified task level by measuring head stability during quiet sitting while systema...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-2001-4
更新日期:2010-02-01 00:00:00
abstract::In order to navigate efficiently, animals can benefit from internal representations of their moment-to-moment orientation. Head-direction (HD) cells are neurons that discharge maximally when the head of a rat is oriented in a specific ("preferred") direction in the horizontal plane, independently from position or ongo...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000365
更新日期:2000-07-01 00:00:00
abstract::When the head rotates, vestibulocollic reflexes counteract the rotation by causing contraction of the neck muscles that pull against the imposed motion. With voluntary head rotations, these same muscles contract and assist the movement of the head. The purpose of this study was to determine if an infinite variety of m...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF02259112
更新日期:1992-01-01 00:00:00
abstract::The current study examines the modulation of the motion-onset response based on the frequency-range of sound stimuli. Delayed motion-onset and stationary stimuli were presented in a free-field by sequentially activating loudspeakers on an azimuthal plane keeping the natural percept of externalized sound presentation. ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-018-5329-9
更新日期:2018-10-01 00:00:00
abstract::The synRas transgenic mice express constitutively activated Valin12-Harvey Ras in postnatal neocortical pyramidal neurons. This leads to somatodendritic hypertrophy, higher densities of spines and synapses, and an enhancement of synaptic long-term potentiation associated with an increased glutamate receptor-mediated a...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-008-1688-y
更新日期:2009-12-01 00:00:00
abstract::The adaptation and habituation characteristics produced by the repeated presentation of a moving visual stimulus were studied in single cells in the pigeon's optic tectum. Units located near the surface in the stratum opticum showed little adaptation. However, cells located in deeper layers exhibited varying rates and...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00235509
更新日期:1977-03-30 00:00:00
abstract::Experimental neurogenic tumors were induced transplacentally in rats by single injections of ethylnitrosourea (ENU). The resulting primary tumors as well as isogenic transplantation tumor lines and clonal cell lines derived therefrom were examined for their content of the brain specific protein 14-3-2 by a quantitativ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00237328
更新日期:1976-05-10 00:00:00
abstract::This study exploited the alterations in pedal speed and joints kinematics elicited by changing crank length (CL) to test how altered task mechanics during cycling will modulate the muscle activation characteristics in human rectus femoris (RF), biceps femoris long head (BF), soleus (SOL) and tibialis anterior (TA). Ki...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-003-1561-y
更新日期:2003-10-01 00:00:00
abstract::The uptake of tritiated gamma-aminobutyric acid (3H-GABA) in the oculomotor nucleus of the cat was studied, using light and electron microscopic examination of radioautograms after intracerebral in vivo administration of the amino-acid. A glial uptake by oligodendrocytes was seen together with a neuronal uptake of the...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00239581
更新日期:1982-01-01 00:00:00
abstract::To address the hypothesis that Parkinson's disease (PD) patients have deficits in controlling acceleration, a drawing task was used in which target size, frequency, and weight of pen were manipulated. In accordance with previous results, it was found that, relative to controls, PD patients produced movements at the re...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-009-1925-z
更新日期:2009-08-01 00:00:00
abstract::Previous studies have shown that the "synaptic" bodies of mammalian pinealocytes are a heterogeneous group of organelles. Whereas "synaptic" ribbons (SR) exhibit a day/night rhythm with small numbers during daytime and high numbers at night, the so-called "synaptic" spherules (SS) show species-specific differences in ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236214
更新日期:1987-01-01 00:00:00
abstract::Dementia due to cerebral ischemic lesions is relatively common in the elderly. Since many of these lesions are probably caused by emboli, studying emboli-induced cerebral lesions in rabbits should, hopefully, provide information that is useful when searching for a means of preventing and treating vascular dementia in ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210050622
更新日期:1999-01-01 00:00:00
abstract::Peak grip aperture has often been used to quantify the influence of illusions on judgments of size for action. However, a larger peak grip aperture need not mean that the object looks larger. It could also mean that it was grasped more carefully. These two possibilities can be distinguished on the basis of the velocit...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0744-8
更新日期:2007-01-01 00:00:00
abstract::We investigated the effects of intracerebroventricular (i.c.v.) pertussis toxin upon the sensitivity of supraoptic oxytocin neurones to intravenous morphine (1-5000 micrograms/kg) in urethane-anaesthetized rats. The maximal inhibitory capacity of morphine was diminished by prior administration of pertussis toxin. Some...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00230292
更新日期:1993-01-01 00:00:00
abstract::The present study extends our previous findings in challenging the traditional interpretation of irregularities in the velocity profile of pointing movements as corrective submovements performed to improve accuracy of target achievement. The study is driven by a hypothesis that pointing includes at least two subtasks,...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0603-7
更新日期:2007-01-01 00:00:00
abstract::Caloric vestibular stimulation (CVS) is a physiological technique demonstrated to transiently improve hemianaesthesia in right brain-damaged patients (Bottini et al. in Exp Brain Res 99(1):164-169, 1994, Nature 376:778-781, 1995, Neurology 65(8):1278-1283, 2005). Recent studies suggest that these effects are based on ...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-010-2450-9
更新日期:2011-01-01 00:00:00
abstract::The survival of grafts of dissociated allogeneic fetal neural dopamine (DA) rich tissue in the striatum has been studied after transplantation between inbred strains of mice differing at defined immunogenetical loci between donor and recipient. Six to 7 weeks and 15 weeks after grafting, surviving grafted DA neurons w...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00253636
更新日期:1989-01-01 00:00:00
abstract::A gradual increase in iron occurs in the lesioned hippocampus after neuronal injury induced by the excitotoxin kainate, and the present study was carried out to investigate whether this increase in iron might be associated with changes in expression of the iron binding protein, ferritin. An increase in ferritin immuno...
journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-004-2110-z
更新日期:2005-03-01 00:00:00