Abstract:
:Unilateral lesions of the right superior colliculus (SC) were made in hamsters on the day after birth. In order to quantify the extent of abnormal innervation by left eye fibers in the diencephalon and midbrain, the left eye was removed on postnatal day 12 or 36, and after an appropriate survival time, the brains were stained for degenerating axons and axon terminals with the Fink-Heimer method. In additional cases, anterograde transport of 3H proline-leucine or horseradish peroxidase was used to assess left eye connectivity. In agreement with previous reports we found abnormal projections in the ventral nucleus of the lateral geniculate body (LGv), in the lateral posterior nucleus (LP) of the thalamus, and in the left SC (the 'recrossing' pathway). We also noted areas of abnormally heavy terminal fields arranged in patches in coronal sections in the dorsal nucleus of the lateral geniculate body (LGd). These patches arise from columns of dense innervation that are oriented along a rostral-to-caudal axis. If the right SC lesion was made large enough to diminish the recrossing pathway, retinofugal axons establish a significantly smaller distal terminal field in the left SC. In these cases, a corresponding increase in the size of terminal fields in all major proximal structures (LGd, LGv, LP, DTN) was observed. The sum of abnormal proximal growth ("compensatory sprouting") was found to truly compensate for the distal loss of terminals. The evaluation of hamsters in which left eye connectivity was assessed at the age of 12 days revealed that lesion-induced patches of abnormal growth have already reached their full size by that time. These findings provide evidence for the 'pruning-effect' and demonstrate that retinofugal axons support a fixed number of terminal arborizations (the principle of 'conservation of total axonal arborizations').
journal_name
Exp Brain Resjournal_title
Experimental brain researchauthors
Sabel BA,Schneider GEdoi
10.1007/BF00406608subject
Has Abstractpub_date
1988-01-01 00:00:00pages
505-18issue
3eissn
0014-4819issn
1432-1106journal_volume
73pub_type
杂志文章abstract::We investigated the association between the degree of lesion overlap with the corticospinal tract and walking performance before and after 4-weeks of partial body weight support (PBWS) treadmill training in 18 individuals (ten male, eight female) with a mean age 59 +/- 13 years (mean +/- SD), range 32-74 years, who we...
journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Experimental brain research
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doi:10.1007/s00221-014-4129-0
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00241503
更新日期:1995-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05802-1
更新日期:2020-08-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231751
更新日期:1991-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00236561
更新日期:1981-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-019-05693-x
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-006-0462-2
更新日期:2006-09-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s002210000536
更新日期:2000-12-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00231260
更新日期:1990-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4367-9
更新日期:2015-11-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-015-4343-4
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00227954
更新日期:1996-12-01 00:00:00
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journal_title:Experimental brain research
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journal_title:Experimental brain research
pub_type: 杂志文章
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journal_title:Experimental brain research
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pub_type: 杂志文章
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更新日期:2007-02-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00249914
更新日期:1989-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章,meta分析
doi:10.1007/s002210000400
更新日期:2000-07-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/BF00238613
更新日期:1982-01-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
doi:10.1007/s00221-020-05871-2
更新日期:2020-10-01 00:00:00
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journal_title:Experimental brain research
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Experimental brain research
pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00