Inactivation of the fis gene leads to reduced growth rate.

Abstract:

:The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli. In this report the growth behaviour of a fis bacterium was studied under steady-state conditions and in competition experiments with a wild-type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.

journal_name

FEMS Microbiol Lett

authors

Nilsson L,Verbeek H,Hoffmann U,Haupt M,Bosch L

doi

10.1016/0378-1097(92)90292-v

keywords:

subject

Has Abstract

pub_date

1992-11-15 00:00:00

pages

85-8

issue

1

eissn

0378-1097

issn

1574-6968

journal_volume

78

pub_type

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