Outer membrane proteins of gentamicin induced small colony variants of Pseudomonas aeruginosa.

Abstract:

:Small colony variants (SCVs) of Pseudomonas aeruginosa NCTC 6750 (WT) were repeatedly isolated in an in vitro kinetic model after exposure to gentamicin (GM). There were minor differences biochemically and in phage and serotyping between the wild type (WT) strain and SCVs. Changes in outer membrane protein profiles were found. SCVs were more resistant to polymixin and to a range of aminoglycosides (except kanamycin), but were more susceptible to a range of other antibiotics (hydrophilic and hydrophobic) with differing modes of action.

journal_name

FEMS Microbiol Lett

authors

Langford PR,Anwar H,Gonda I,Brown MR

doi

10.1016/0378-1097(89)90165-1

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

33-6

issue

1-2

eissn

0378-1097

issn

1574-6968

journal_volume

52

pub_type

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