Isolation and characterization of a Staphylococcus warneri strain producing an anti-Legionella peptide.

Abstract:

:Legionella pneumophila is a pathogenic bacterium found in freshwater environments that is responsible for pneumonia. People become infected through inhalation of contaminated droplets from water devices, such as cooling towers and showers. It is important to find new treatments that decrease the development of Legionella. We found a Staphylococcus warneri strain that inhibits Legionella growth. This activity is due to a molecule secreted by S. warneri. This molecule displayed a high heat-stability and its activity was lost after protease treatments, suggesting that it might be a bacteriocin. Its purification led us to conclude that this anti-Legionella molecule is an highly hydrophobic peptide. It has an original and very specific spectrum of activity, directed only toward the Legionella genus. This is the first description of an antibacterial peptide active against Legionella.

journal_name

FEMS Microbiol Lett

authors

Héchard Y,Ferraz S,Bruneteau E,Steinert M,Berjeaud JM

doi

10.1016/j.femsle.2005.03.046

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

19-23

issue

1

eissn

0378-1097

issn

1574-6968

pii

S0378-1097(05)00206-5

journal_volume

252

pub_type

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