Abstract:
OBJECTIVES:To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV). GOAL:Compare the prevalence of different HPV types and the risk factors for HPV positivity in three sites. RESULTS:The most frequently detected HPV types in all sites were, in decreasing order, HPV16, 53, 18, 61 and 81. Agreement between the cervix and vagina was good (kappa 0.60 - 0.80) for HPV16 and 53 and excellent (Kappa > 0.80) for HPV18 and 61. HPV positivity was inversely associated with age for all combinations including the anal site. CONCLUSION:In HIV positive women, HPV18 is the most spread HPV type found in combinations of anal and genital sites. The relationship of anal to genital infection has implications for the development of anal malignancies. Thus, the efficacy of the current HPV vaccine may be considered not only for the cervix, but also for prevention of HPV18 anal infection among immunossuppressed individuals.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Gonçalves MA,Randi G,Arslan A,Villa LL,Burattini MN,Franceschi S,Donadi EA,Massad Edoi
10.1186/1750-9378-3-5subject
Has Abstractpub_date
2008-03-14 00:00:00pages
5issn
1750-9378pii
1750-9378-3-5journal_volume
3pub_type
杂志文章abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-019-0226-9
更新日期:2019-04-16 00:00:00
abstract:Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0199-0
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). METHODS:In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of di...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-18
更新日期:2010-10-12 00:00:00
abstract:Background:The Instituto Angolano de Controlo do Cancer (IACC) Cancer Registry in Luanda, Angola is the most ancient and organized hospital-based cancer registry in Angola and provides data on cancer cases treated in several hospital facilities in Luanda. Methods:Newly-diagnosed cancer cases (2012-2016) of IACC were c...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0249-2
更新日期:2019-11-08 00:00:00
abstract:BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0049-x
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-24
更新日期:2014-07-18 00:00:00
abstract:Background:Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0231-z
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-19
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-6
更新日期:2007-03-02 00:00:00
abstract:BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0094-5
更新日期:2016-08-22 00:00:00
abstract:BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which ha...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-15
更新日期:2014-05-06 00:00:00
abstract:: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-6
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study i...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0006-0
更新日期:2015-04-10 00:00:00
abstract:BACKGROUND:The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM:To review the literature on studies examining the association between ovarian cancer and bacterial or ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-017-0134-9
更新日期:2017-05-18 00:00:00
abstract::Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. In particular,...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0182-9
更新日期:2018-04-05 00:00:00
abstract:BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0128-7
更新日期:2017-03-23 00:00:00
abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-3
更新日期:2007-01-31 00:00:00
abstract::In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-16
更新日期:2013-05-04 00:00:00
abstract::Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), al...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0174-9
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0024-y
更新日期:2015-09-01 00:00:00
abstract:UNLABELLED: BACKGROUND:Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection d...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-7-19
更新日期:2012-08-08 00:00:00
abstract::The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0110-9
更新日期:2016-12-06 00:00:00
abstract:Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0191-8
更新日期:2018-06-08 00:00:00
abstract:BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0001-5
更新日期:2015-03-02 00:00:00
abstract::Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. The...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-46
更新日期:2013-12-02 00:00:00
abstract:: Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the M...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-5
更新日期:2011-04-28 00:00:00
abstract::Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-23
更新日期:2013-06-20 00:00:00
abstract:Background:Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in HCV treated patients is an emerging clinical problem which needs to be investigated. In this study ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-00300-z
更新日期:2020-05-27 00:00:00
abstract:: The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men in 1981 in the West heralded the onset of the human immunodeficiency virus (HIV) infection epidemic, which remains one of the biggest challenges to global public health and science ever. Because KS and NHL were incre...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-16
更新日期:2011-10-17 00:00:00
abstract:BACKGROUND:Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0151-8
更新日期:2017-07-19 00:00:00