Abstract：
: Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the Middle East only few populations, such as Ashkenazi and Sephardic groups in Israel, have been adequately evaluated for HHV-8 seroprevalence. Among Iranian population a striking higher seroprevalence of HHV8 has been reported among haemodialysis (16.9%), renal transplant recipients (25%) and HIV (45.7%) patients compared to blood donors (2%). Kaposi's sarcoma (KS) is the rarest cancer in Iran, with an annual age-standardized incidence varying from 0.10 to 0.17 per 100,000 in males and from 0.06 to 0.08 per 100,000 in females. KS, however, is one of the most important malignancies in Iranian renal transplanted patients affecting up to 2.4% of organ recipients. The epidemiology of HHV8 and KS in Iran needs further evaluation. While the high prevalence of HHV-8 antibodies in HIV positive and haemodialysis individuals may be attributed to high-risk sexual behavior and polytransfusions, respectively, unknown determinants may be responsible for high seroprevalence of HHV8 and high incidence of KS in solid organ recipients. A global survey on HHV8 seroprevalence in Iran is mandatory to define co-factors associated with HHV8 infection and KS risk in the general Iranian population and in specific patient groups.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Jalilvand S,Shoja Z,Mokhtari-Azad T,Nategh R,Gharehbaghian Adoi
10.1186/1750-9378-6-5subject
Has Abstractpub_date
2011-04-28 00:00:00pages
5issn
1750-9378pii
1750-9378-6-5journal_volume
6pub_type
杂志文章abstract：BACKGROUND:Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Althoug...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-12
更新日期：2014-04-14 00:00:00
abstract：Background:Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in HCV treated patients is an emerging clinical problem which needs to be investigated. In this study ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-00300-z
更新日期：2020-05-27 00:00:00
abstract：BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-6
更新日期：2007-03-02 00:00:00
abstract：BACKGROUND:The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitopes. Several clinical trials include gene-based vaccines encoding this protein. ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-14
更新日期：2007-07-10 00:00:00
abstract：OBJECTIVES:To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV). GOAL:Compare the prevalence of different HPV types and the risk factors for HPV positivity in thre...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-3-5
更新日期：2008-03-14 00:00:00
abstract：BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0128-7
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0079-4
更新日期：2016-07-05 00:00:00
abstract：:In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-16
更新日期：2013-05-04 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific d...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-016-0099-0
更新日期：2016-10-12 00:00:00
abstract：:Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription fact...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-020-00317-4
更新日期：2020-10-15 00:00:00
abstract：BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which ha...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-15
更新日期：2014-05-06 00:00:00
abstract：Background:Human papillomavirus (HPV) infection causes around 90% of cervical cancer cases, and cervical cancer is a leading cause of female mortality worldwide. HPV-derived oncoprotein E7 participates in cervical carcinogenesis by inducing aberrant host DNA methylation. However, the targeting specificity of E7 methyla...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-0271-4
更新日期：2020-02-03 00:00:00
abstract：Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0263-4
更新日期：2019-11-29 00:00:00
abstract：BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-20
更新日期：2007-11-13 00:00:00
abstract：:Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-019-0226-9
更新日期：2019-04-16 00:00:00
abstract：Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0199-0
更新日期：2018-07-24 00:00:00
abstract：: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-6
更新日期：2013-02-01 00:00:00
abstract：:The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses,...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-48
更新日期：2013-12-10 00:00:00
abstract：BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0024-y
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-19
更新日期：2007-10-24 00:00:00
abstract：UNLABELLED: BACKGROUND:Liver disease is the second cause of death among HIV patients receiving highly active antiretroviral therapy (HAART) in Europe. HIV patients have a high prevalence of chronic HBV (6-10%) and HCV (33%) co-infection, and accelerated progression of viral hepatitis. Furthermore, the long duration of...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-7-15
更新日期：2012-06-28 00:00:00
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journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0159-0
更新日期：2017-09-30 00:00:00
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journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-00294-8
更新日期：2020-04-29 00:00:00
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journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0110-9
更新日期：2016-12-06 00:00:00
abstract：:Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. In particular,...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-018-0182-9
更新日期：2018-04-05 00:00:00
abstract：:A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-3
更新日期：2007-01-31 00:00:00
abstract：BACKGROUND:Human Papillomavirus (HPV) detection results comparing paraffin embedded cervical tissue and other cervical specimens have been done with varying degrees of agreement. However, studies comparing freshly frozen specimens and paraffin embedded specimens of invasive cervical carcinomas are lacking. The aim of t...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-5-15
更新日期：2010-09-16 00:00:00
abstract：BACKGROUND:With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-10-4
更新日期：2015-02-02 00:00:00
abstract：BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0046-0
更新日期：2016-01-15 00:00:00
abstract：Background:Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0231-z
更新日期：2019-06-28 00:00:00
