Viral infections in prostate carcinomas in Chilean patients.


BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patients. METHODS:Sixty-nine primary prostate carcinomas were analyzed for the presence of HPV, BKPyV and JCPyV using standard polymerase chain reaction protocols. In addition, when samples were positive for HPyV, large T antigen (TAg) transcripts were analyzed using reverse transcriptase PCR. RESULTS:HPV and JCPyV were not detected in any specimens (0/69, 0 %); whereas, BKPyV was detected in 6/69 PCas (8.7 %). We did not find a statistically significant association between the presence of BKPyV and age (p = 0.198) or Gleason score (p = 0.268). In addition, 2/6 (33 %) BKPyV positive specimens showed detectable levels of TAg transcripts. CONCLUSIONS:There was no association between HPV or JCPyV presence and prostate cancer development. The presence of BKPyV in a small subset of prostate carcinomas in Chilean patients could indicate that this virus plays a potential role in prostate cancer development and requires further investigation.


Infect Agent Cancer


Rodríguez H,Levican J,Muñoz JP,Carrillo D,Acevedo ML,Gaggero A,León O,Gheit T,Espinoza-Navarro O,Castillo J,Gallegos I,Tommasino M,Aguayo F




Has Abstract


2015-09-01 00:00:00










  • HIV and cancer: a comparative retrospective study of Brazilian and U.S. clinical cohorts.

    abstract:BACKGROUND:With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Castilho JL,Luz PM,Shepherd BE,Turner M,Ribeiro SR,Bebawy SS,Netto JS,McGowan CC,Veloso VG,Engels EA,Sterling TR,Grinsztejn B

    更新日期:2015-02-02 00:00:00

  • The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma.

    abstract:BACKGROUND:Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Althoug...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Ambrosio MR,Navari M,Di Lisio L,Leon EA,Onnis A,Gazaneo S,Mundo L,Ulivieri C,Gomez G,Lazzi S,Piris MA,Leoncini L,De Falco G

    更新日期:2014-04-14 00:00:00

  • The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis.

    abstract::Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription fact...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审


    authors: Charostad J,Nakhaie M,Dehghani A,Faghihloo E

    更新日期:2020-10-15 00:00:00

  • Introduction of p16INK4a as a surrogate biomarker for HPV in women with invasive cervical cancer in Sudan.

    abstract:BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Sarwath H,Bansal D,Husain NE,Mohamed M,Sultan AA,Bedri S

    更新日期:2017-09-30 00:00:00

  • MDM2 285G>C and 344T>A gene variants and their association with hepatocellular carcinoma: a Moroccan case-control study.

    abstract:BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Rebbani K,Ezzikouri S,Marchio A,Kandil M,Pineau P,Benjelloun S

    更新日期:2014-04-07 00:00:00

  • Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.

    abstract:BACKGROUND:Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Vidal AC,Murphy SK,Hernandez BY,Vasquez B,Bartlett JA,Oneko O,Mlay P,Obure J,Overcash F,Smith JS,van der Kolk M,Hoyo C

    更新日期:2011-11-14 00:00:00

  • Bcr-Abl tyrosine kinase inhibitors- current status.

    abstract::Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Mughal A,Aslam HM,Khan AM,Saleem S,Umah R,Saleem M

    更新日期:2013-06-20 00:00:00

  • Cross-sectional study about primary health care professionals views on the inclusion of the vaccine against human papillomavirus in the vaccine schedules.

    abstract:BACKGROUND:Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have received from many source. The Knowledge of primary health care professionals affects the information...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Pérez MR,Violeta VB,Del Campo AV,Ruiz C,Castaño SY,Conde LP,López JS

    更新日期:2015-11-16 00:00:00

  • The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis.

    abstract:BACKGROUND:The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM:To review the literature on studies examining the association between ovarian cancer and bacterial or ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审


    authors: Ingerslev K,Hogdall E,Schnack TH,Skovrider-Ruminski W,Hogdall C,Blaakaer J

    更新日期:2017-05-18 00:00:00

  • Salvage chemotherapy for adults with relapsed or refractory lymphoma in Malawi.

    abstract:BACKGROUND:Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are no second-line treatment descriptions for adults with relapsed or refractory lymphoma (RRL) in SSA. ...

    journal_title:Infectious agents and cancer



    authors: Kaimila B,van der Gronde T,Stanley C,Kasonkanji E,Chikasema M,Tewete B,Fox P,Gopal S

    更新日期:2017-08-09 00:00:00

  • Prevalence of "unclassified" HPV genotypes among women with abnormal cytology.

    abstract:Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Annunziata C,Stellato G,Greggi S,Sanna V,Curcio MP,Losito S,Botti G,Buonaguro L,Buonaguro FM,Tornesello ML

    更新日期:2018-07-24 00:00:00

  • The relationship between anti-HPV-16 IgG seropositivity and cancer of the cervix, anogenital organs, oral cavity and pharynx, oesophagus and prostate in a black South African population.

    abstract:BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Sitas F,Urban M,Stein L,Beral V,Ruff P,Hale M,Patel M,O'Connell D,Yu XQ,Verzijden A,Marais D,Williamson AL

    更新日期:2007-03-02 00:00:00

  • Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic.

    abstract:BACKGROUND:Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Though NPCs are more radiosensitive and chemosensitive than other tumors of the upper aero-digestive tract, many therapeutic challenges remain. In a previous report, we have presented data supporting a possible the...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Vérillaud B,Gressette M,Morel Y,Paturel C,Herman P,Lo KW,Tsao SW,Wassef M,Jimenez-Pailhes AS,Busson P

    更新日期:2012-12-03 00:00:00

  • Immunization of mice with the nef gene from Human Immunodeficiency Virus type 1: study of immunological memory and long-term toxicology.

    abstract:BACKGROUND:The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitopes. Several clinical trials include gene-based vaccines encoding this protein. ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Bråve A,Gudmundsdotter L,Gasteiger G,Hallermalm K,Kastenmuller W,Rollman E,Boberg A,Engström G,Reiland S,Cosma A,Drexler I,Hinkula J,Wahren B,Erfle V

    更新日期:2007-07-10 00:00:00

  • Comparison of human papillomavirus detection between freshly frozen tissue and paraffin embedded tissue of invasive cervical cancer.

    abstract:BACKGROUND:Human Papillomavirus (HPV) detection results comparing paraffin embedded cervical tissue and other cervical specimens have been done with varying degrees of agreement. However, studies comparing freshly frozen specimens and paraffin embedded specimens of invasive cervical carcinomas are lacking. The aim of t...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Odida M,de Sanjose S,Sandin S,Quiros B,Alemany L,Lloveras B,Quint W,Kleter B,Alejo M,van Doorn LJ,Weiderpass E

    更新日期:2010-09-16 00:00:00

  • The effects of antiviral treatment on breast cancer cell line.

    abstract:BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Shaimerdenova M,Karapina O,Mektepbayeva D,Alibek K,Akilbekova D

    更新日期:2017-03-23 00:00:00

  • Possible stimulation of anti-tumor immunity using repeated cold stress: a hypothesis.

    abstract:BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Shevchuk NA,Radoja S

    更新日期:2007-11-13 00:00:00

  • Host proteome linked to HPV E7-mediated specific gene hypermethylation in cancer pathways.

    abstract:Background:Human papillomavirus (HPV) infection causes around 90% of cervical cancer cases, and cervical cancer is a leading cause of female mortality worldwide. HPV-derived oncoprotein E7 participates in cervical carcinogenesis by inducing aberrant host DNA methylation. However, the targeting specificity of E7 methyla...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Na Rangsee N,Yanatatsaneejit P,Pisitkun T,Somparn P,Jintaridth P,Topanurak S

    更新日期:2020-02-03 00:00:00

  • Quantification of human bocavirus in lower respiratory tract infections in China.

    abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Lin F,Zeng A,Yang N,Lin H,Yang E,Wang S,Pintel D,Qiu J

    更新日期:2007-01-31 00:00:00

  • Association between oncogenic human papillomavirus type 16 and Killian polyp.

    abstract:BACKGROUND:Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. METHODS:DNA from antral (n = 14) and nasal (n = 14...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Oton-Gonzalez L,Rotondo JC,Cerritelli L,Malagutti N,Lanzillotti C,Bononi I,Ciorba A,Bianchini C,Mazziotta C,De Mattei M,Pelucchi S,Tognon M,Martini F

    更新日期:2021-01-07 00:00:00

  • Presence of Porphyromonas gingivalis in esophagus and its association with the clinicopathological characteristics and survival in patients with esophageal cancer.

    abstract:BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Gao S,Li S,Ma Z,Liang S,Shan T,Zhang M,Zhu X,Zhang P,Liu G,Zhou F,Yuan X,Jia R,Potempa J,Scott DA,Lamont RJ,Wang H,Feng X

    更新日期:2016-01-19 00:00:00

  • Human papillomavirus genotypes distribution among Gabonese women with normal cytology and cervical abnormalities.

    abstract:BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Zoa Assoumou S,Ndjoyi Mbiguino A,Mabika Mabika B,Nguizi Ogoula S,El Mzibri M,Khattabi A,Ennaji MM

    更新日期:2016-01-15 00:00:00

  • HIV status, age at cervical Cancer screening and cervical cytology outcomes in an opportunistic screening setting in Nigeria: a 10-year Cross sectional data analysis.

    abstract:Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Musa J,Achenbach CJ,Evans CT,Jordan N,Daru PH,Silas O,Sagay AS,Anorlu R,Mehta SD,Wehbe F,Simon MA,Adewole IF,Hou L,Murphy RL

    更新日期:2019-11-29 00:00:00

  • Mentoring future Kenyan oncology researchers.

    abstract::This is a summary of the 1st Academic Model Providing Access to Healthcare (AMPATH) Oncology Institute research grant writing workshop organized in collaboration with the Kenya Medical Research Institute (KEMRI) and held in Kisumu, Kenya from January 16th to 18th, 2013. The goal of this meeting was to mentor future Ke...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Moormann A,Skiles J,Koros E,Asirwa FC,Busakhala N,Loehrer P

    更新日期:2013-10-07 00:00:00

  • Hepatocellular carcinoma and liver metastases: clinical data on a new dual-lumen catheter kit for surgical sealant infusion to prevent perihepatic bleeding and dissemination of cancer cells following biopsy and loco-regional treatments.

    abstract:BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study i...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Izzo F,Palaia R,Albino V,Amore A,di Giacomo R,Piccirillo M,Leongito M,Nasto A,Granata V,Petrillo A,Lastoria S

    更新日期:2015-04-10 00:00:00

  • Prevalence and predictors of kaposi sarcoma herpes virus seropositivity: a cross-sectional analysis of HIV-infected adults initiating ART in Johannesburg, South Africa.

    abstract:BACKGROUND:Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS. KSHV co-infection may be associated with worse outcomes in HIV disease and elevated KSHV viral load may be an early marker for advanced H...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Maskew M,Macphail AP,Whitby D,Egger M,Wallis CL,Fox MP

    更新日期:2011-11-17 00:00:00

  • Prevalence of type-specific HPV among female university students from northern Brazil.

    abstract:BACKGROUND:Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availability of data on the prevalence of type-specific HPV in young women in the pre-immunization period, alt...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Vieira RC,Monteiro Jdo S,Manso EP,Dos Santos MR,Tsutsumi MY,Ishikawa EA,Ferrari SF,Lima KV,de Sousa MS

    更新日期:2015-07-22 00:00:00

  • Plasmablastic lymphoma in Malawi.

    abstract::Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HI...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Zuze T,Painschab MS,Seguin R,Kudowa E,Kaimila B,Kasonkanji E,Tomoka T,Dhungel BM,Mulenga M,Chikasema M,Tewete B,Ntangwanika A,Chiyoyola S,Chimzimu F,Kampani C,Krysiak R,Montgomery ND,Fedoriw Y,Gopal S

    更新日期:2018-06-28 00:00:00

  • Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection.

    abstract:BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Grützmeier S,Porwit A,Schmitt C,Sandström E,Åkerlund B,Ernberg I

    更新日期:2016-08-22 00:00:00

  • Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs.

    abstract:BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章


    authors: Kantathavorn N,Mahidol C,Sritana N,Sricharunrat T,Phoolcharoen N,Auewarakul C,Teerayathanakul N,Taepisitpong C,Saeloo S,Sornsamdang G,Udomchaiprasertkul W,Krongthong W,Arnamwong A

    更新日期:2015-03-02 00:00:00