Abstract:
Background:The Instituto Angolano de Controlo do Cancer (IACC) Cancer Registry in Luanda, Angola is the most ancient and organized hospital-based cancer registry in Angola and provides data on cancer cases treated in several hospital facilities in Luanda. Methods:Newly-diagnosed cancer cases (2012-2016) of IACC were collected. A total of 6638 malignant neoplasms were recorded. After excluding duplicates, missing data and non-melanoma skin cancers cases, a final number of 5609 cancer cases was considered valid for analysis. Results:From 5609 new cases, 2059 were males and 3550 females. Of all cases, 9.7% was in children below the age of 15 years. Most of the cases were residents from the Luanda district. The five most common cancers for all periods were breast (21.4%), cervix (16.8%), prostate (7.1%), non-Hodgkin lymphoma (4.5%) and Kaposi sarcoma (4.3%). For men, 19.3% of the cancers were prostate, 7.5% Kaposi sarcoma and 7.5% non-Hodgkin lymphoma. Cancers of the breast and cervix together accounted 60% of all cancers in females. Comparison of our data onto the 5 most frequent tumours, by sex, according to GLOBOCAN 2018 estimations for Angola, highlights the potential deviation from reality that estimates may have and reinforces the urgent need to build a truly population-based cancer registry in Luanda. Conclusion:To accomplish that task, it is mandatory to implement a more rigorous quality control program at the hospital-based cancer registry at IACC and to optimize the network of health institutions that actively working on and contributing to the cancer registry, in Luanda.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Miguel F,Bento MJ,de Lacerda GF,Weiderpass E,Santos LLdoi
10.1186/s13027-019-0249-2subject
Has Abstractpub_date
2019-11-08 00:00:00pages
35issn
1750-9378pii
249journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS. KSHV co-infection may be associated with worse outcomes in HIV disease and elevated KSHV viral load may be an early marker for advanced H...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-22
更新日期:2011-11-17 00:00:00
abstract:BACKGROUND:The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Ora...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0096-3
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availability of data on the prevalence of type-specific HPV in young women in the pre-immunization period, alt...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0017-x
更新日期:2015-07-22 00:00:00
abstract:BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0128-7
更新日期:2017-03-23 00:00:00
abstract:BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0079-4
更新日期:2016-07-05 00:00:00
abstract:BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0001-5
更新日期:2015-03-02 00:00:00
abstract:BACKGROUND:Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have received from many source. The Knowledge of primary health care professionals affects the information...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0034-9
更新日期:2015-11-16 00:00:00
abstract::The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses,...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-48
更新日期:2013-12-10 00:00:00
abstract:BACKGROUND:Morbidity and mortality data highlight prostate cancer as the most commonly diagnosed neoplasm in Jamaican males. This report examines the association between dietary patterns and risk of prostate cancer in Jamaican men. MATERIALS AND METHODS:Case-control study of 204 histologically confirmed newly diagnose...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-4-S1-S5
更新日期:2009-02-10 00:00:00
abstract:BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-6
更新日期:2007-03-02 00:00:00
abstract:UNLABELLED: BACKGROUND:Liver disease is the second cause of death among HIV patients receiving highly active antiretroviral therapy (HAART) in Europe. HIV patients have a high prevalence of chronic HBV (6-10%) and HCV (33%) co-infection, and accelerated progression of viral hepatitis. Furthermore, the long duration of...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-7-15
更新日期:2012-06-28 00:00:00
abstract:BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0046-0
更新日期:2016-01-15 00:00:00
abstract::Helicobacter pylori is an important yet unproven etiological agent of gastric cancer. H. pylori infection is more prevalent in developing Asian countries like India and it is usually acquired at an early age. It has been two decades since Marshall and Warren (1984) first described curved bacilli in the stomach of ulce...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-2
更新日期:2007-01-04 00:00:00
abstract:BACKGROUND:Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0151-8
更新日期:2017-07-19 00:00:00
abstract:BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study i...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0006-0
更新日期:2015-04-10 00:00:00
abstract:Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0263-4
更新日期:2019-11-29 00:00:00
abstract::Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. In particular,...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0182-9
更新日期:2018-04-05 00:00:00
abstract::Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), al...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0174-9
更新日期:2018-01-15 00:00:00
abstract::The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0110-9
更新日期:2016-12-06 00:00:00
abstract:BACKGROUND:Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-20
更新日期:2011-11-14 00:00:00
abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-019-0226-9
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0002-4
更新日期:2015-02-17 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0159-0
更新日期:2017-09-30 00:00:00
abstract::We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0225-x
更新日期:2019-04-08 00:00:00
abstract::Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HI...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0195-4
更新日期:2018-06-28 00:00:00
abstract:BACKGROUND:The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM:To review the literature on studies examining the association between ovarian cancer and bacterial or ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-017-0134-9
更新日期:2017-05-18 00:00:00
abstract:Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0191-8
更新日期:2018-06-08 00:00:00
abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0024-y
更新日期:2015-09-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific d...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-016-0099-0
更新日期:2016-10-12 00:00:00
abstract:BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0049-x
更新日期:2016-01-19 00:00:00