Abstract:
Background:Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors. Material and methods:Our study aimed to investigate the effects of PRP-gel on the rate of tumor relapse by using a mouse model of Human Fibrosarcoma (HF). The radical resection of tumors of mice was conducted under fluorescence-guidance (FGR) by using MacroFluo microscope, after a primary tumor removal with bright-light surgery (BLS). Results:It was found that the lesion recurrence and the tumor growth were reduced in mice treated with PRP observed in each group of treatment (50%) after 30 days from tumor excision, respect to controls (without statistical significance; p = 0.12). The histopathological and immune-histochemical analysis did not report differences in cellular morphology between the tumors of control and PRP-treated mice. Conclusion:Our data suggest that PRP-gel, used as an adjuvant treatment for the stimulation of tissue repair and speed up recovery, can impair tumor growth and slow the tumor.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Barbieri A,Bimonte S,Loquercio G,Rea D,Cascella M,Anniciello A,Luciano A,Palma G,Di Costanzo G,Rosa A,Giuliano P,Arra Cdoi
10.1186/s13027-019-0237-6subject
Has Abstractpub_date
2019-08-28 00:00:00pages
21issn
1750-9378pii
237journal_volume
14pub_type
杂志文章abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-019-0226-9
更新日期:2019-04-16 00:00:00
abstract:Background:The Instituto Angolano de Controlo do Cancer (IACC) Cancer Registry in Luanda, Angola is the most ancient and organized hospital-based cancer registry in Angola and provides data on cancer cases treated in several hospital facilities in Luanda. Methods:Newly-diagnosed cancer cases (2012-2016) of IACC were c...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0249-2
更新日期:2019-11-08 00:00:00
abstract::Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. The...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-46
更新日期:2013-12-02 00:00:00
abstract::This is a summary of the 1st Academic Model Providing Access to Healthcare (AMPATH) Oncology Institute research grant writing workshop organized in collaboration with the Kenya Medical Research Institute (KEMRI) and held in Kisumu, Kenya from January 16th to 18th, 2013. The goal of this meeting was to mentor future Ke...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-40
更新日期:2013-10-07 00:00:00
abstract:BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0094-5
更新日期:2016-08-22 00:00:00
abstract::Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-23
更新日期:2013-06-20 00:00:00
abstract:BACKGROUND:The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-24
更新日期:2014-07-18 00:00:00
abstract:BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0046-0
更新日期:2016-01-15 00:00:00
abstract:BACKGROUND:With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-10-4
更新日期:2015-02-02 00:00:00
abstract::We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0225-x
更新日期:2019-04-08 00:00:00
abstract:BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which ha...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-15
更新日期:2014-05-06 00:00:00
abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-3
更新日期:2007-01-31 00:00:00
abstract::Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific d...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-016-0099-0
更新日期:2016-10-12 00:00:00
abstract:Background:Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in HCV treated patients is an emerging clinical problem which needs to be investigated. In this study ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-00300-z
更新日期:2020-05-27 00:00:00
abstract:Background:The detection of the Epstein-Barr capsid antigen (VCA) immunoglobulin A (IgA) is widely used in the diagnosis of nasopharyngeal carcinoma (NPC), but a reference standard for evaluating the presence of VCA-IgA is not yet available. Therefore, a reference standard is urgently needed for a uniform and quantitat...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-00294-8
更新日期:2020-04-29 00:00:00
abstract:Background:The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patte...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0210-9
更新日期:2018-11-29 00:00:00
abstract:OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0002-4
更新日期:2015-02-17 00:00:00
abstract::The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0110-9
更新日期:2016-12-06 00:00:00
abstract:BACKGROUND:To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). METHODS:In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of di...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-18
更新日期:2010-10-12 00:00:00
abstract:: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-6
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0024-y
更新日期:2015-09-01 00:00:00
abstract:UNLABELLED: BACKGROUND:Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection d...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-7-19
更新日期:2012-08-08 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV). GOAL:Compare the prevalence of different HPV types and the risk factors for HPV positivity in thre...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-3-5
更新日期:2008-03-14 00:00:00
abstract:BACKGROUND:Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. METHODS:DNA from antral (n = 14) and nasal (n = 14...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-00342-3
更新日期:2021-01-07 00:00:00
abstract:Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0263-4
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Morbidity and mortality data highlight prostate cancer as the most commonly diagnosed neoplasm in Jamaican males. This report examines the association between dietary patterns and risk of prostate cancer in Jamaican men. MATERIALS AND METHODS:Case-control study of 204 histologically confirmed newly diagnose...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-4-S1-S5
更新日期:2009-02-10 00:00:00
abstract:BACKGROUND:The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitopes. Several clinical trials include gene-based vaccines encoding this protein. ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-14
更新日期:2007-07-10 00:00:00
abstract:BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-20
更新日期:2007-11-13 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0159-0
更新日期:2017-09-30 00:00:00
abstract::Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription fact...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-020-00317-4
更新日期:2020-10-15 00:00:00