Abstract：
BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection were associated with serum prostate-specific antigen (PSA) concentration, a marker of prostatic disease and inflammation. RESULTS:The percentage of men between the ages of 40 and 59 with a PSA > or = 4.0 ng/ml was 2.6% (95% confidence interval [CI], 1.8% - 3.8%). The percentage of men between the ages of 40 and 59 self-reporting a past diagnosis of genital warts or genital herpes, or a recent diagnosis of gonorrhea or chlamydia is estimated to be 7.3% (95% CI, 6.2% - 8.6%). Men self-reporting that they had had sex without using a condom in the past month had a lower PSA concentration and higher %fPSA than those who did not. There were no associations between any of the other sexual activity or laboratory measures and PSA or %fPSA. CONCLUSION:In this nationally representative sample of middle-aged American men, we did not find consistent evidence for an association between sexual behavior or a history of STIs and PSA levels. Therefore, sexual factors are unlikely to lead to falsely elevated PSA tests in this population. We cannot rule out the role of these factors in causing false positive PSA tests in subgroups of the population that have a higher prevalence of high-risk sexual behavior, and more protracted or recent exposures to these agents.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Werny DM,Saraiya M,Chen X,Platz EAdoi
10.1186/1750-9378-2-19subject
Has Abstractpub_date
2007-10-24 00:00:00pages
19issn
1750-9378pii
1750-9378-2-19journal_volume
2pub_type
杂志文章abstract：Background:The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patte...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0210-9
更新日期：2018-11-29 00:00:00
abstract：BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0024-y
更新日期：2015-09-01 00:00:00
abstract：Background:Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0231-z
更新日期：2019-06-28 00:00:00
abstract：BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0049-x
更新日期：2016-01-19 00:00:00
abstract：:The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses,...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-48
更新日期：2013-12-10 00:00:00
abstract：Background:The detection of the Epstein-Barr capsid antigen (VCA) immunoglobulin A (IgA) is widely used in the diagnosis of nasopharyngeal carcinoma (NPC), but a reference standard for evaluating the presence of VCA-IgA is not yet available. Therefore, a reference standard is urgently needed for a uniform and quantitat...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-00294-8
更新日期：2020-04-29 00:00:00
abstract：BACKGROUND:The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM:To review the literature on studies examining the association between ovarian cancer and bacterial or ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-017-0134-9
更新日期：2017-05-18 00:00:00
abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS. KSHV co-infection may be associated with worse outcomes in HIV disease and elevated KSHV viral load may be an early marker for advanced H...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-22
更新日期：2011-11-17 00:00:00
abstract：BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0128-7
更新日期：2017-03-23 00:00:00
abstract：:Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), al...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-018-0174-9
更新日期：2018-01-15 00:00:00
abstract：:The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0110-9
更新日期：2016-12-06 00:00:00
abstract：Background:The Instituto Angolano de Controlo do Cancer (IACC) Cancer Registry in Luanda, Angola is the most ancient and organized hospital-based cancer registry in Angola and provides data on cancer cases treated in several hospital facilities in Luanda. Methods:Newly-diagnosed cancer cases (2012-2016) of IACC were c...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0249-2
更新日期：2019-11-08 00:00:00
abstract：BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-20
更新日期：2007-11-13 00:00:00
abstract：:A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-3
更新日期：2007-01-31 00:00:00
abstract：BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-11
更新日期：2014-04-07 00:00:00
abstract：:Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific d...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-016-0099-0
更新日期：2016-10-12 00:00:00
abstract：Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0263-4
更新日期：2019-11-29 00:00:00
abstract：: Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the M...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-5
更新日期：2011-04-28 00:00:00
abstract：BACKGROUND:The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Ora...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0096-3
更新日期：2016-08-26 00:00:00
abstract：BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0001-5
更新日期：2015-03-02 00:00:00
abstract：:Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-23
更新日期：2013-06-20 00:00:00
abstract：Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0191-8
更新日期：2018-06-08 00:00:00
abstract：: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-6
更新日期：2013-02-01 00:00:00
abstract：:Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-019-0226-9
更新日期：2019-04-16 00:00:00
abstract：BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0094-5
更新日期：2016-08-22 00:00:00
abstract：BACKGROUND:The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-24
更新日期：2014-07-18 00:00:00
abstract：BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-6
更新日期：2007-03-02 00:00:00
abstract：UNLABELLED: BACKGROUND:Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E. coli) infection is responsible for 70% of urinary tract infection. This study aimed to evaluate the role of chronic E. coli infection d...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-7-19
更新日期：2012-08-08 00:00:00
abstract：:Helicobacter pylori is an important yet unproven etiological agent of gastric cancer. H. pylori infection is more prevalent in developing Asian countries like India and it is usually acquired at an early age. It has been two decades since Marshall and Warren (1984) first described curved bacilli in the stomach of ulce...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-2
更新日期：2007-01-04 00:00:00
abstract：:In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-16
更新日期：2013-05-04 00:00:00
