Bcr-Abl tyrosine kinase inhibitors- current status.

Abstract:

:Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Dasatinib (BMS-345825) are second generation drugs that are intended to have less resistance and intolerance than imatinib. Ponatinib (AP24534) an orally active Bcr-Abl Tyrosine Kinase Inhibitor and Bafetinib (INNO-406) have efficacy against various point mutations in the Bcr-Abl kinase. 1, 3, 4 thiadiazole derivatives has also displayed moderate inhibitory action on both Abl and Src kinase family. However there are varieties of Bcr-Abl inhibitors but Nilotinib is still the frontline tyrosine kinase inhibitors.

journal_name

Infect Agent Cancer

authors

Mughal A,Aslam HM,Khan AM,Saleem S,Umah R,Saleem M

doi

10.1186/1750-9378-8-23

subject

Has Abstract

pub_date

2013-06-20 00:00:00

pages

23

issue

1

issn

1750-9378

pii

1750-9378-8-23

journal_volume

8

pub_type

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