Abstract：
:Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. These drugs seem to target tumor cells in a moment of vulnerability when they are undergoing DNA repair. In the past few years this class of anti-cancer drug has been discovered to show a promising niche in the clinic.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Usmani H,Hussain SA,Sheikh Adoi
10.1186/1750-9378-8-46subject
Has Abstractpub_date
2013-12-02 00:00:00pages
46issue
1issn
1750-9378pii
1750-9378-8-46journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0151-8
更新日期：2017-07-19 00:00:00
abstract：BACKGROUND:Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. METHODS:DNA from antral (n = 14) and nasal (n = 14...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-00342-3
更新日期：2021-01-07 00:00:00
abstract：: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-6
更新日期：2013-02-01 00:00:00
abstract：BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0079-4
更新日期：2016-07-05 00:00:00
abstract：:Helicobacter pylori is an important yet unproven etiological agent of gastric cancer. H. pylori infection is more prevalent in developing Asian countries like India and it is usually acquired at an early age. It has been two decades since Marshall and Warren (1984) first described curved bacilli in the stomach of ulce...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-2
更新日期：2007-01-04 00:00:00
abstract：BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0128-7
更新日期：2017-03-23 00:00:00
abstract：:We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0225-x
更新日期：2019-04-08 00:00:00
abstract：BACKGROUND:Human Papillomavirus (HPV) detection results comparing paraffin embedded cervical tissue and other cervical specimens have been done with varying degrees of agreement. However, studies comparing freshly frozen specimens and paraffin embedded specimens of invasive cervical carcinomas are lacking. The aim of t...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-5-15
更新日期：2010-09-16 00:00:00
abstract：:The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa including information on the availability of data on cancer burden, screening and prevention for cancer in Africa, cancer care ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0110-9
更新日期：2016-12-06 00:00:00
abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS. KSHV co-infection may be associated with worse outcomes in HIV disease and elevated KSHV viral load may be an early marker for advanced H...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-22
更新日期：2011-11-17 00:00:00
abstract：OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0002-4
更新日期：2015-02-17 00:00:00
abstract：Background:The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patte...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0210-9
更新日期：2018-11-29 00:00:00
abstract：BACKGROUND:With successful antiretroviral therapy, non-communicable diseases, including malignancies, are increasingly contributing to morbidity and mortality among HIV-infected persons. The epidemiology of AIDS-defining cancers (ADCs) and non-AIDS-defining cancers (NADCs) in HIV-infected populations in Brazil has not ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-10-4
更新日期：2015-02-02 00:00:00
abstract：BACKGROUND:Morbidity and mortality data highlight prostate cancer as the most commonly diagnosed neoplasm in Jamaican males. This report examines the association between dietary patterns and risk of prostate cancer in Jamaican men. MATERIALS AND METHODS:Case-control study of 204 histologically confirmed newly diagnose...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-4-S1-S5
更新日期：2009-02-10 00:00:00
abstract：BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-6
更新日期：2007-03-02 00:00:00
abstract：Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0191-8
更新日期：2018-06-08 00:00:00
abstract：BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-20
更新日期：2007-11-13 00:00:00
abstract：BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0024-y
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0094-5
更新日期：2016-08-22 00:00:00
abstract：:The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-016-0077-6
更新日期：2016-07-19 00:00:00
abstract：BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0046-0
更新日期：2016-01-15 00:00:00
abstract：Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0263-4
更新日期：2019-11-29 00:00:00
abstract：BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0001-5
更新日期：2015-03-02 00:00:00
abstract：BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0159-0
更新日期：2017-09-30 00:00:00
abstract：Background:Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0231-z
更新日期：2019-06-28 00:00:00
abstract：Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0199-0
更新日期：2018-07-24 00:00:00
abstract：BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-11
更新日期：2014-04-07 00:00:00
abstract：Background:The Instituto Angolano de Controlo do Cancer (IACC) Cancer Registry in Luanda, Angola is the most ancient and organized hospital-based cancer registry in Angola and provides data on cancer cases treated in several hospital facilities in Luanda. Methods:Newly-diagnosed cancer cases (2012-2016) of IACC were c...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0249-2
更新日期：2019-11-08 00:00:00
abstract：BACKGROUND:Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Althoug...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-12
更新日期：2014-04-14 00:00:00
abstract：: The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men in 1981 in the West heralded the onset of the human immunodeficiency virus (HIV) infection epidemic, which remains one of the biggest challenges to global public health and science ever. Because KS and NHL were incre...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-16
更新日期：2011-10-17 00:00:00
