Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC).

Abstract:

OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR was performed to amplify two viral genes; EBV nuclear antigen-4 (EBNA-4) and latent membrane protein-1 (LMP1). RESULTS:EBV genes were detected in 92/150 (61.3%) tissue samples. Of the 92 infected samples, 58/92 (63%) were found among males and 34/92 (37%) were among females. CONCLUSION:EBV is prevalent in the Sudan and responsible of the vast majority of cases of NPC.

journal_name

Infect Agent Cancer

authors

Ahmed HG,Suliman RS,El Aziz MS,Alshammari FD

doi

10.1186/s13027-015-0002-4

subject

Has Abstract

pub_date

2015-02-17 00:00:00

pages

6

issn

1750-9378

pii

2

journal_volume

10

pub_type

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