Prevalence of "unclassified" HPV genotypes among women with abnormal cytology.

Abstract:

Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liquid-based cytological samples were collected from 337 women referred for colposcopy following an abnormal cytological diagnosis. HPV DNA was detected by broad-spectrum PCR and genotypes identified by nucleotide sequencing analysis and reverse line blot (RLB). Results:The overall frequency of HPV infection was 36.5% (35 out of 96) in samples negative for intraepithelial lesions or malignancy (NILM), 80% (181 out of 226) in low grade SIL and 93.3% (14 out of 15) in high grade SIL (P < 0.001). Thirty-five different genotypes were identified among the 230 HPV-positive cases. The Group 1 oncogenic viruses (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59) were found in 21.9, 46.5, and 86.7% of NILM, low grade SIL and high grade SIL, respectively. The Group 2A, including the probably oncogenic virus HPV68, was found in 1 and 0.8% of NILM and low grade SIL, respectively. The Group 2b possibly oncogenic HPVs (HPV34, 53, 66, 67, 70, 73, 82 and 85) were found in 4.2, 21.7 and 26.7% of NILM, low grade SIL and high grade SIL, respectively. The unclassified viruses (HPV12, 42, 54, 55, 61, 62, 81, 83, 84, 89, 90, 91) were detected in 8.3 and 14.6% of NILM and low grade SIL, respectively, and never in high grade SIL. Conclusions:Group 1 HPVs were mainly prevalent in high grade SIL and low grade SIL while Group 2B were equally distributed among the two groups. The dominant frequency of unclassified HPVs in low grade SIL and NILM and their rarity in high grade SIL suggests their marginal role in cervical neoplasia of the studied population.

journal_name

Infect Agent Cancer

authors

Annunziata C,Stellato G,Greggi S,Sanna V,Curcio MP,Losito S,Botti G,Buonaguro L,Buonaguro FM,Tornesello ML

doi

10.1186/s13027-018-0199-0

subject

Has Abstract

pub_date

2018-07-24 00:00:00

pages

26

issn

1750-9378

pii

199

journal_volume

13

pub_type

杂志文章
  • Fulminant anaplastic large cell lymphoma (ALCL) concomitant with primary cytomegalovirus (CMV) infection, and human herpes virus 8 (HHV-8) infection together with Epstein-Barr-virus (EBV) reactivation in a patient with asymptomatic HIV-infection.

    abstract:BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-016-0094-5

    authors: Grützmeier S,Porwit A,Schmitt C,Sandström E,Åkerlund B,Ernberg I

    更新日期:2016-08-22 00:00:00

  • Infections and cancer: debate about using vaccines as a cancer control tool.

    abstract::In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-8-16

    authors: Mbulaiteye SM,Buonaguro FM

    更新日期:2013-05-04 00:00:00

  • Prevalence of human papillomavirus in saliva of women with HPV genital lesions.

    abstract:BACKGROUND:The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Ora...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-016-0096-3

    authors: Visalli G,Currò M,Facciolà A,Riso R,Mondello P,Laganà P,Di Pietro A,Picerno I,Spataro P

    更新日期:2016-08-26 00:00:00

  • The effects of the use of platelet-rich plasma gel on local recurrence in an animal model of human fibrosarcoma.

    abstract:Background:Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors. Material ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-019-0237-6

    authors: Barbieri A,Bimonte S,Loquercio G,Rea D,Cascella M,Anniciello A,Luciano A,Palma G,Di Costanzo G,Rosa A,Giuliano P,Arra C

    更新日期:2019-08-28 00:00:00

  • The co-evolved Helicobacter pylori and gastric cancer: trinity of bacterial virulence, host susceptibility and lifestyle.

    abstract::Helicobacter pylori is an important yet unproven etiological agent of gastric cancer. H. pylori infection is more prevalent in developing Asian countries like India and it is usually acquired at an early age. It has been two decades since Marshall and Warren (1984) first described curved bacilli in the stomach of ulce...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-2-2

    authors: Akhter Y,Ahmed I,Devi SM,Ahmed N

    更新日期:2007-01-04 00:00:00

  • The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma.

    abstract:BACKGROUND:Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Althoug...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-9-12

    authors: Ambrosio MR,Navari M,Di Lisio L,Leon EA,Onnis A,Gazaneo S,Mundo L,Ulivieri C,Gomez G,Lazzi S,Piris MA,Leoncini L,De Falco G

    更新日期:2014-04-14 00:00:00

  • Dissecting the roles of thymoquinone on the prevention and the treatment of hepatocellular carcinoma: an overview on the current state of knowledge.

    abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s13027-019-0226-9

    authors: Bimonte S,Albino V,Barbieri A,Tamma ML,Nasto A,Palaia R,Molino C,Bianco P,Vitale A,Schiano R,Giudice A,Cascella M

    更新日期:2019-04-16 00:00:00

  • Viral infections in prostate carcinomas in Chilean patients.

    abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-015-0024-y

    authors: Rodríguez H,Levican J,Muñoz JP,Carrillo D,Acevedo ML,Gaggero A,León O,Gheit T,Espinoza-Navarro O,Castillo J,Gallegos I,Tommasino M,Aguayo F

    更新日期:2015-09-01 00:00:00

  • Relapses of primary cutaneous anaplastic large-cell lymphoma in a female immunocompetent patient with persistent chlamydophila pneumoniae and human herpesvirus 8 infection.

    abstract:BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-016-0079-4

    authors: Caselli E,Borghi A,Maritati M,Gafà R,Lanza G,Di Luca D,Virgili A,Contini C

    更新日期:2016-07-05 00:00:00

  • Association between oncogenic human papillomavirus type 16 and Killian polyp.

    abstract:BACKGROUND:Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. METHODS:DNA from antral (n = 14) and nasal (n = 14...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-020-00342-3

    authors: Oton-Gonzalez L,Rotondo JC,Cerritelli L,Malagutti N,Lanzillotti C,Bononi I,Ciorba A,Bianchini C,Mazziotta C,De Mattei M,Pelucchi S,Tognon M,Martini F

    更新日期:2021-01-07 00:00:00

  • Prevalence of type-specific HPV among female university students from northern Brazil.

    abstract:BACKGROUND:Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availability of data on the prevalence of type-specific HPV in young women in the pre-immunization period, alt...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-015-0017-x

    authors: Vieira RC,Monteiro Jdo S,Manso EP,Dos Santos MR,Tsutsumi MY,Ishikawa EA,Ferrari SF,Lima KV,de Sousa MS

    更新日期:2015-07-22 00:00:00

  • HIV and cancer in Africa: mutual collaboration between HIV and cancer programs may provide timely research and public health data.

    abstract:: The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men in 1981 in the West heralded the onset of the human immunodeficiency virus (HIV) infection epidemic, which remains one of the biggest challenges to global public health and science ever. Because KS and NHL were incre...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-6-16

    authors: Mbulaiteye SM,Bhatia K,Adebamowo C,Sasco AJ

    更新日期:2011-10-17 00:00:00

  • The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis.

    abstract::Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription fact...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s13027-020-00317-4

    authors: Charostad J,Nakhaie M,Dehghani A,Faghihloo E

    更新日期:2020-10-15 00:00:00

  • Infrequent detection of human papillomavirus infection in head and neck cancers in the Central African Republic: a retrospective study.

    abstract::We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-019-0225-x

    authors: Kofi B,Mossoro-Kpinde CD,Mboumba Bouassa RS,Péré H,Robin L,Gresenguet G,Bélec L

    更新日期:2019-04-08 00:00:00

  • The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis.

    abstract:BACKGROUND:The etiological cause of ovarian cancer is poorly understood. It has been theorized that bacterial or viral infection as well as pelvic inflammatory disease could play a role in ovarian carcinogenesis. AIM:To review the literature on studies examining the association between ovarian cancer and bacterial or ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s13027-017-0134-9

    authors: Ingerslev K,Hogdall E,Schnack TH,Skovrider-Ruminski W,Hogdall C,Blaakaer J

    更新日期:2017-05-18 00:00:00

  • Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic.

    abstract:BACKGROUND:Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Though NPCs are more radiosensitive and chemosensitive than other tumors of the upper aero-digestive tract, many therapeutic challenges remain. In a previous report, we have presented data supporting a possible the...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-7-36

    authors: Vérillaud B,Gressette M,Morel Y,Paturel C,Herman P,Lo KW,Tsao SW,Wassef M,Jimenez-Pailhes AS,Busson P

    更新日期:2012-12-03 00:00:00

  • Hepatitis C virus (HCV) genotypes distribution: an epidemiological up-date in Europe.

    abstract::Hepatitis C virus (HCV) infection is a major public health burden in Europe, causing an increasing level of liver-related morbidity and mortality, characterized by several regional variations in the genotypes distribution. A comprehensive review of the literature from 2000 to 2015 was used to gather country-specific d...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s13027-016-0099-0

    authors: Petruzziello A,Marigliano S,Loquercio G,Cacciapuoti C

    更新日期:2016-10-12 00:00:00

  • Seroprevalence of Human herpesvirus 8 (HHV-8) and incidence of Kaposi's sarcoma in Iran.

    abstract:: Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the M...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-6-5

    authors: Jalilvand S,Shoja Z,Mokhtari-Azad T,Nategh R,Gharehbaghian A

    更新日期:2011-04-28 00:00:00

  • HPV vaccines and cancer prevention, science versus activism.

    abstract:: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-8-6

    authors: Tomljenovic L,Wilyman J,Vanamee E,Bark T,Shaw CA

    更新日期:2013-02-01 00:00:00

  • High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues.

    abstract:BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which ha...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-9-15

    authors: Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Gogusev J,Jaubert F,Nakamoto S,Yamakawa M,Nakamine H,Takata K,Oka T,Yoshino T

    更新日期:2014-05-06 00:00:00

  • Distribution of HPV genotypes in cervical intraepithelial lesions and cervical cancer in Tanzanian women.

    abstract:BACKGROUND:Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-6-20

    authors: Vidal AC,Murphy SK,Hernandez BY,Vasquez B,Bartlett JA,Oneko O,Mlay P,Obure J,Overcash F,Smith JS,van der Kolk M,Hoyo C

    更新日期:2011-11-14 00:00:00

  • Hepatocellular carcinoma and liver metastases: clinical data on a new dual-lumen catheter kit for surgical sealant infusion to prevent perihepatic bleeding and dissemination of cancer cells following biopsy and loco-regional treatments.

    abstract:BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study i...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-015-0006-0

    authors: Izzo F,Palaia R,Albino V,Amore A,di Giacomo R,Piccirillo M,Leongito M,Nasto A,Granata V,Petrillo A,Lastoria S

    更新日期:2015-04-10 00:00:00

  • Dissecting the mechanisms and molecules underlying the potential carcinogenicity of red and processed meat in colorectal cancer (CRC): an overview on the current state of knowledge.

    abstract::Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), al...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章,评审

    doi:10.1186/s13027-018-0174-9

    authors: Cascella M,Bimonte S,Barbieri A,Del Vecchio V,Caliendo D,Schiavone V,Fusco R,Granata V,Arra C,Cuomo A

    更新日期:2018-01-15 00:00:00

  • HIV status, age at cervical Cancer screening and cervical cytology outcomes in an opportunistic screening setting in Nigeria: a 10-year Cross sectional data analysis.

    abstract:Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-019-0263-4

    authors: Musa J,Achenbach CJ,Evans CT,Jordan N,Daru PH,Silas O,Sagay AS,Anorlu R,Mehta SD,Wehbe F,Simon MA,Adewole IF,Hou L,Murphy RL

    更新日期:2019-11-29 00:00:00

  • MDM2 285G>C and 344T>A gene variants and their association with hepatocellular carcinoma: a Moroccan case-control study.

    abstract:BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-9-11

    authors: Rebbani K,Ezzikouri S,Marchio A,Kandil M,Pineau P,Benjelloun S

    更新日期:2014-04-07 00:00:00

  • Quantification of human bocavirus in lower respiratory tract infections in China.

    abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-2-3

    authors: Lin F,Zeng A,Yang N,Lin H,Yang E,Wang S,Pintel D,Qiu J

    更新日期:2007-01-31 00:00:00

  • Molecular screening for Epstein Barr virus (EBV) among Sudanese patients with nasopharyngeal carcinoma (NPC).

    abstract:OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-015-0002-4

    authors: Ahmed HG,Suliman RS,El Aziz MS,Alshammari FD

    更新日期:2015-02-17 00:00:00

  • Host proteome linked to HPV E7-mediated specific gene hypermethylation in cancer pathways.

    abstract:Background:Human papillomavirus (HPV) infection causes around 90% of cervical cancer cases, and cervical cancer is a leading cause of female mortality worldwide. HPV-derived oncoprotein E7 participates in cervical carcinogenesis by inducing aberrant host DNA methylation. However, the targeting specificity of E7 methyla...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/s13027-020-0271-4

    authors: Na Rangsee N,Yanatatsaneejit P,Pisitkun T,Somparn P,Jintaridth P,Topanurak S

    更新日期:2020-02-03 00:00:00

  • Is human cytomegalovirus associated with breast cancer progression?

    abstract:BACKGROUND:It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possi...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-8-12

    authors: Utrera-Barillas D,Valdez-Salazar HA,Gómez-Rangel D,Alvarado-Cabrero I,Aguilera P,Gómez-Delgado A,Ruiz-Tachiquin ME

    更新日期:2013-04-04 00:00:00

  • Are food patterns associated with prostate cancer in Jamaican men: a preliminary report.

    abstract:BACKGROUND:Morbidity and mortality data highlight prostate cancer as the most commonly diagnosed neoplasm in Jamaican males. This report examines the association between dietary patterns and risk of prostate cancer in Jamaican men. MATERIALS AND METHODS:Case-control study of 204 histologically confirmed newly diagnose...

    journal_title:Infectious agents and cancer

    pub_type: 杂志文章

    doi:10.1186/1750-9378-4-S1-S5

    authors: Jackson M,Walker S,Simpson C,McFarlane-Anderson N,Bennett F

    更新日期:2009-02-10 00:00:00