Abstract:
BACKGROUND:Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer; however, these genotypes remain poorly characterized in many African countries. To contribute to the characterization of HPV genotypes in Northeastern Tanzania, we recruited 215 women from the Reproductive Health Clinic at Kilimanjaro Christian Medical Centre. Cervical scrapes and biopsies were obtained for cytology and HPV DNA detection. RESULTS:79 out of 215 (36.7%) enrolled participants tested positive for HPV DNA, with a large proportion being multiple infections (74%). The prevalence of HPV infection increased with lesion grade (14% in controls, 67% in CIN1 cases and 88% in CIN2-3). Among ICC cases, 89% had detectable HPV. Overall, 31 HPV genotypes were detected; the three most common HPV genotypes among ICC were HPV16, 35 and 45. In addition to these genotypes, co-infection with HPV18, 31, 33, 52, 58, 68 and 82 was found in 91% of ICC. Among women with CIN2-3, HPV53, 58 and 84/83 were the most common. HPV35, 45, 53/58/59 were the most common among CIN1 cases. CONCLUSIONS:In women with no evidence of cytological abnormalities, the most prevalent genotypes were HPV58 with HPV16, 35, 52, 66 and 73 occurring equally. Although numerical constraints limit inference, findings that 91% of ICC harbor only a small number of HPV genotypes suggests that prevention efforts including vaccine development or adjuvant screening should focus on these genotypes.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Vidal AC,Murphy SK,Hernandez BY,Vasquez B,Bartlett JA,Oneko O,Mlay P,Obure J,Overcash F,Smith JS,van der Kolk M,Hoyo Cdoi
10.1186/1750-9378-6-20subject
Has Abstractpub_date
2011-11-14 00:00:00pages
20issue
1issn
1750-9378pii
1750-9378-6-20journal_volume
6pub_type
杂志文章abstract:Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0191-8
更新日期:2018-06-08 00:00:00
abstract::Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV are highly endemic. We identified 12 patients with pathologically confirmed PBL from a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26-71), seven (58%) were male, and six (50%) were HI...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0195-4
更新日期:2018-06-28 00:00:00
abstract::This is a summary of the 1st Academic Model Providing Access to Healthcare (AMPATH) Oncology Institute research grant writing workshop organized in collaboration with the Kenya Medical Research Institute (KEMRI) and held in Kisumu, Kenya from January 16th to 18th, 2013. The goal of this meeting was to mentor future Ke...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-40
更新日期:2013-10-07 00:00:00
abstract::Human polyomaviruses (HPyV), which are small DNA viruses classified into the polyomaviridae family, are widely distributed in human populations. Thirteen distinct HPyVs have been described to date. Some of these viruses have been found in human tumors, suggesting an etiological relationship with cancer. In particular,...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0182-9
更新日期:2018-04-05 00:00:00
abstract::In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-16
更新日期:2013-05-04 00:00:00
abstract:Background:Hepatitis C virus (HCV) represents a major risk factor for hepatocellular carcinoma (HCC) development and anti-HCV therapy is a significant measure to reduce the incidence of HCC, however development of HCC in HCV treated patients is an emerging clinical problem which needs to be investigated. In this study ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-00300-z
更新日期:2020-05-27 00:00:00
abstract::Meat is a crucial nutrient for human health since it represents a giant supply of proteins, minerals, and vitamins. On the opposite hand, the intake of red and processed meat is taken into account dangerous due to its potential of carcinogenesis and cancer risk improvement, particularly for colorectal cancer (CRC), al...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-018-0174-9
更新日期:2018-01-15 00:00:00
abstract:BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0049-x
更新日期:2016-01-19 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0159-0
更新日期:2017-09-30 00:00:00
abstract:BACKGROUND:Cervical cancer is one of the most common tumors affecting women with a disproportionate mortality occurring in developing countries. Despite the high prevalence of cervical cancer and cervical neoplasia in Gabon, few studies have been performed to evaluate the prevalence and determinants of HPV infection in...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0046-0
更新日期:2016-01-15 00:00:00
abstract:Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0199-0
更新日期:2018-07-24 00:00:00
abstract:BACKGROUND:Human papillomavirus type 16 (HPV-16) infection is an important cause of cervical cancer, other anogenital cancers and, possibly, some oral and pharyngeal cancers. The association of HPV-16 with oesophageal and with prostate cancers has not been firmly established. METHODS:We analysed sera from 3,757 HIV se...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-6
更新日期:2007-03-02 00:00:00
abstract:BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0079-4
更新日期:2016-07-05 00:00:00
abstract:OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0002-4
更新日期:2015-02-17 00:00:00
abstract:: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-6
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). METHODS:In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of di...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-18
更新日期:2010-10-12 00:00:00
abstract:: Seroepidemiological surveys show that the prevalence of human herpesvirus 8 (HHV-8) infection mostly varies in various geographical areas and reflects the local incidence of classic and endemic KS, being widespread in sub-Saharan Africa and Mediterranean countries and uncommon in the USA and Northern Europe. In the M...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-5
更新日期:2011-04-28 00:00:00
abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-3
更新日期:2007-01-31 00:00:00
abstract::Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-23
更新日期:2013-06-20 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Though NPCs are more radiosensitive and chemosensitive than other tumors of the upper aero-digestive tract, many therapeutic challenges remain. In a previous report, we have presented data supporting a possible the...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-7-36
更新日期:2012-12-03 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV). GOAL:Compare the prevalence of different HPV types and the risk factors for HPV positivity in thre...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-3-5
更新日期:2008-03-14 00:00:00
abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-019-0226-9
更新日期:2019-04-16 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-19
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:Human Papillomavirus (HPV) detection results comparing paraffin embedded cervical tissue and other cervical specimens have been done with varying degrees of agreement. However, studies comparing freshly frozen specimens and paraffin embedded specimens of invasive cervical carcinomas are lacking. The aim of t...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-15
更新日期:2010-09-16 00:00:00
abstract:BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-11
更新日期:2014-04-07 00:00:00
abstract:BACKGROUND:It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possi...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-12
更新日期:2013-04-04 00:00:00
abstract:Background:The aims of this study were to evaluate whether HPV infection has a prognostic role in patients with esophageal squamous cell carcinoma who underwent oncological treatment and also to compare the heat shock proteins (Hsp) 90, 27 and 16.2 and growth hormone-releasing hormone receptor (GHRH-R) expression patte...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0210-9
更新日期:2018-11-29 00:00:00
abstract::The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses,...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-48
更新日期:2013-12-10 00:00:00
abstract:BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study i...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0006-0
更新日期:2015-04-10 00:00:00
abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0024-y
更新日期:2015-09-01 00:00:00