Abstract:
BACKGROUND:RFA is a safe and effective procedure for treating unresectable primary or secondary liver malignancies, but it is not without complications. The most common reported complications include abdominal hemorrhage, bile leakage, biloma formation, hepatic abscesses, and neoplastic seeding. The aim of this study is to evaluate the feasibility of percutaneous use of surgical sealant with a new coaxial bilumen catheter, to prevent the perihepatic bleeding and dissemination of cancer cells through the needle-electrode (neoplastic seeding) or along the needle track. METHODS:We designed a novel dual-lumen catheter to facilitate the optimal application of fibrin sealant after diagnostic and therapeutic percutaneous procedures. Percutaneous RFA has been performed using mask ventilation or neuroleptanalgesia. The main aims of this study, after the ablation procedure, in the treatment of unresectable liver cancer were to prevent major adverse events: a) the perihepatic bleeding; b) dissemination of cancer cells through the needle-electrode and or needle track. RESULTS:A total of 181 patients were evaluated for this study at National Cancer Institute of Naples from January 2012 to January 2014. The association of blood loss (≤1 g/dl; ≥1 g/dl) with age, gender, histological diagnosis were analyzed. No statistical significance was observed between bleeding and age (p = 0.840), gender (p = 0.607) and histological diagnosis (p = 0,571), respectively. CONCLUSIONS:This study demonstrated that fibrin sealant or other surgical sealant injection, after any locoregional procedure such as biopsy or ablation, could make adverse events even more rare.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Izzo F,Palaia R,Albino V,Amore A,di Giacomo R,Piccirillo M,Leongito M,Nasto A,Granata V,Petrillo A,Lastoria Sdoi
10.1186/s13027-015-0006-0subject
Has Abstractpub_date
2015-04-10 00:00:00pages
11issn
1750-9378pii
6journal_volume
10pub_type
杂志文章abstract::The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-016-0077-6
更新日期:2016-07-19 00:00:00
abstract:BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which ha...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-15
更新日期:2014-05-06 00:00:00
abstract::Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title:Infectious agents and cancer
pub_type: 杂志文章,评审
doi:10.1186/s13027-019-0226-9
更新日期:2019-04-16 00:00:00
abstract:OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0002-4
更新日期:2015-02-17 00:00:00
abstract:BACKGROUND:The human papilloma viruses (HPVs) are DNA viruses associated with benign and malignant lesions of skin and mucous membranes. The HPVs has been implicated as the cause of virtually all cervical cancers worldwide but studies showed that these viruses can cause numerous cancers in several tissues including Ora...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0096-3
更新日期:2016-08-26 00:00:00
abstract:BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0128-7
更新日期:2017-03-23 00:00:00
abstract::A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-3
更新日期:2007-01-31 00:00:00
abstract:BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-9-11
更新日期:2014-04-07 00:00:00
abstract:BACKGROUND:We have previously reported the case of an immunocompetent female patient with a primary cutaneous CD30+ anaplastic large-cell lymphoma (PCALCL) located on her upper right eyelid characterized by the presence of a concurrent active infection by C. pneumoniae and Human herpesvirus 8 (HHV8). This finding sugge...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-016-0079-4
更新日期:2016-07-05 00:00:00
abstract:: The rationale behind current worldwide human papilloma virus (HPV) vaccination programs starts from two basic premises, 1) that HPV vaccines will prevent cervical cancers and save lives and, 2) have no risk of serious side effects. Therefore, efforts should be made to get as many pre-adolescent girls vaccinated in or...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-6
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-20
更新日期:2007-11-13 00:00:00
abstract:: The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men in 1981 in the West heralded the onset of the human immunodeficiency virus (HIV) infection epidemic, which remains one of the biggest challenges to global public health and science ever. Because KS and NHL were incre...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-16
更新日期:2011-10-17 00:00:00
abstract:BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-19
更新日期:2007-10-24 00:00:00
abstract:BACKGROUND:It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possi...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-12
更新日期:2013-04-04 00:00:00
abstract:BACKGROUND:The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitopes. Several clinical trials include gene-based vaccines encoding this protein. ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-2-14
更新日期:2007-07-10 00:00:00
abstract:OBJECTIVES:To evaluate the prevalence of human papillomavirus (HPV) types, and risk factors for HPV positivity across cervix, vagina and anus, we conducted a study among 138 women with human immunodeficiency virus (HIV). GOAL:Compare the prevalence of different HPV types and the risk factors for HPV positivity in thre...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-3-5
更新日期:2008-03-14 00:00:00
abstract::This is a summary of the 1st Academic Model Providing Access to Healthcare (AMPATH) Oncology Institute research grant writing workshop organized in collaboration with the Kenya Medical Research Institute (KEMRI) and held in Kisumu, Kenya from January 16th to 18th, 2013. The goal of this meeting was to mentor future Ke...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-40
更新日期:2013-10-07 00:00:00
abstract:BACKGROUND:Human Papillomavirus (HPV) detection results comparing paraffin embedded cervical tissue and other cervical specimens have been done with varying degrees of agreement. However, studies comparing freshly frozen specimens and paraffin embedded specimens of invasive cervical carcinomas are lacking. The aim of t...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-15
更新日期:2010-09-16 00:00:00
abstract::We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0225-x
更新日期:2019-04-08 00:00:00
abstract:BACKGROUND:Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availability of data on the prevalence of type-specific HPV in young women in the pre-immunization period, alt...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0017-x
更新日期:2015-07-22 00:00:00
abstract:Background:Invasive cervical cancer (ICC) is more prevalent in HIV infected women and occurs at younger median age than in HIV negative women. Organized cervical cancer screening (CCS) is presently lacking in Nigeria, and the age at CCS is not known in this population. We sought to examine the age at CCS, the cytology ...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-019-0263-4
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:Cervical cancer is the major cause of morbidity and mortality in Thai women. Nevertheless, the preventive strategy such as HPV vaccination program has not been implemented at the national level. This study explored the HPV prevalence and genotypic distribution in a large cohort of Thai women. METHODS:A hosp...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0001-5
更新日期:2015-03-02 00:00:00
abstract:BACKGROUND:Cervical cancer is the fourth most common cancer in women worldwide with highest incidence reported in Eastern Africa in 2012. The primary goal of this study was to study the expression of p16INK4a in squamous cell carcinoma (SCC) of the cervix by immunohistochemistry (IHC) and determine relation with clinic...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-017-0159-0
更新日期:2017-09-30 00:00:00
abstract:BACKGROUND:A few viruses have been detected in prostate cancer, however their role in the development of this malignancy has not been determined. The aim of this study was to analyze the presence and functionality of human papillomavirus (HPV) and polyomaviruses (BKPyV and JCPyV) in prostate carcinomas in Chilean patie...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-015-0024-y
更新日期:2015-09-01 00:00:00
abstract:Background:Human papillomavirus (HPV) infection causes around 90% of cervical cancer cases, and cervical cancer is a leading cause of female mortality worldwide. HPV-derived oncoprotein E7 participates in cervical carcinogenesis by inducing aberrant host DNA methylation. However, the targeting specificity of E7 methyla...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-020-0271-4
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Infection with human papillomavirus (HPV) is associated with uterine cervical intraepithelial neoplasia (CIN) and invasive cancers (ICC). Approximately 80% of ICC cases are diagnosed in under-developed countries. Vaccine development relies on knowledge of HPV genotypes characteristic of LSIL, HSIL and cancer...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-6-20
更新日期:2011-11-14 00:00:00
abstract:Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/s13027-018-0199-0
更新日期:2018-07-24 00:00:00
abstract::In 2012, Infectious Agents and Cancer commissioned a thematic series collection of articles on Prevention of HPV related cancer. The articles have attracted wide interest and stimulated debate, including about the utility of vaccines in cancer control. The application of vaccines to cancer control fulfills a promise e...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-8-16
更新日期:2013-05-04 00:00:00
abstract:BACKGROUND:Nasopharyngeal carcinomas (NPC) are consistently associated with the Epstein-Barr virus (EBV). Though NPCs are more radiosensitive and chemosensitive than other tumors of the upper aero-digestive tract, many therapeutic challenges remain. In a previous report, we have presented data supporting a possible the...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-7-36
更新日期:2012-12-03 00:00:00
abstract:BACKGROUND:To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). METHODS:In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of di...
journal_title:Infectious agents and cancer
pub_type: 杂志文章
doi:10.1186/1750-9378-5-18
更新日期:2010-10-12 00:00:00