Abstract：
BACKGROUND:Langerhans cell (LC) sarcoma (LCS) is a high-grade neoplasm with overtly malignant cytologic features and an LC phenotype. We very recently suggested that LC behaves as a reservoir for common dermotropic Merkel cell polyomavirus (MCPyV) and determined the relationship between LC histiocytosis (LCH), which has an underlining oncogenic capacity, and MCPyV as a trigger for a reactive process rather than a neoplastic process. We propose LC to be a reservoir for MCPyV and hypothesize that some LCS subtypes may be related to the MCPyV agent. FINDINGS:We examined seven LCS tissues using multiplex quantitative PCR (Q-PCR) and immunohistochemistry with anti MCPyV large-T (LT) antigen antibody. High viral loads of MCPyV DNA sequences (viral load = relative levels of MCPyV) were detected (0.328-0.772 copies/cell (Merkel cell carcinoma (MCC) = 1.0)) using Q-PCR in 43% (3/7) tissues, but LT antigen expression was not observed (0/7). CONCLUSIONS:Frequent MCPyV-DNA amplification suggests that LCS in some patients may be related to MCPyV infection. Moreover, the higher viral load of LCS (median, 0.453 copies/cell) than low load of LCH (0.003, median of 12 cases) (P < 0.01) may suggest a virally induced tumorigenic process in some LCS. Although the absence of LT antigen expression may indicate a different role for MCPyV in this pathology, some subtypes of LCS may develop in the background of MCPyV-infected LC. To the best of our knowledge, this is the first report on the relationship between MCPyV and LCS. The recent discovery of MCPyV opened new therapeutic avenues for MCC. These data open novel possibilities for therapeutic interventions against LCS.
journal_name
Infect Agent Cancerjournal_title
Infectious agents and cancerauthors
Murakami I,Matsushita M,Iwasaki T,Kuwamoto S,Kato M,Horie Y,Hayashi K,Gogusev J,Jaubert F,Nakamoto S,Yamakawa M,Nakamine H,Takata K,Oka T,Yoshino Tdoi
10.1186/1750-9378-9-15subject
Has Abstractpub_date
2014-05-06 00:00:00pages
15issn
1750-9378pii
1750-9378-9-15journal_volume
9pub_type
杂志文章abstract：Background:Platelet-rich-plasma (PRP) is largely used, thanks to its properties, as wound therapy after surgical resection. Several studies and clinical findings have demonstrated that the PRP can accelerate the regeneration and the repair of tissues through the action of the platelet-derived growth factors. Material ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0237-6
更新日期：2019-08-28 00:00:00
abstract：BACKGROUND:Kaposi sarcoma (KS) is the most common AIDS-defining tumour in HIV-infected individuals in Africa. Kaposi sarcoma herpes virus (KSHV) infection precedes development of KS. KSHV co-infection may be associated with worse outcomes in HIV disease and elevated KSHV viral load may be an early marker for advanced H...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-22
更新日期：2011-11-17 00:00:00
abstract：BACKGROUND:Gastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0151-8
更新日期：2017-07-19 00:00:00
abstract：BACKGROUND:Most malignant lymphomas in HIV-patients are caused by reactivation of EBV-infection. Some lymphomas have a very rapid fulminant course. HHV-8 has also been reported to be a cause of lymphoma. The role of CMV in the development of lymphoma is not clear, though both CMV and HHV-8 have been reported in tissues...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0094-5
更新日期：2016-08-22 00:00:00
abstract：BACKGROUND:Lymphoma is highly associated with HIV in sub-Saharan Africa (SSA), which contributes to worse outcomes relative to resource-rich settings, and frequent failure of first-line chemotherapy. However, there are no second-line treatment descriptions for adults with relapsed or refractory lymphoma (RRL) in SSA. ...
journal_title：Infectious agents and cancer
pub_type：
doi：10.1186/s13027-017-0156-3
更新日期：2017-08-09 00:00:00
abstract：:A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections (LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-3
更新日期：2007-01-31 00:00:00
abstract：Background:Human papillomavirus (HPV) infection causes around 90% of cervical cancer cases, and cervical cancer is a leading cause of female mortality worldwide. HPV-derived oncoprotein E7 participates in cervical carcinogenesis by inducing aberrant host DNA methylation. However, the targeting specificity of E7 methyla...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-0271-4
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possi...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-12
更新日期：2013-04-04 00:00:00
abstract：BACKGROUND:Human papillomavirus (HPV) infection is associated with cervical cancer, the most frequent cancer in women from northern Brazil. Assessment of the short-term impact of HPV vaccination depends on the availability of data on the prevalence of type-specific HPV in young women in the pre-immunization period, alt...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0017-x
更新日期：2015-07-22 00:00:00
abstract：BACKGROUND:The phenomenon of hormesis, whereby small amounts of seemingly harmful or stressful agents can be beneficial for the health and lifespan of laboratory animals has been reported in literature. In particular, there is accumulating evidence that daily brief cold stress can increase both numbers and activity of ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-20
更新日期：2007-11-13 00:00:00
abstract：BACKGROUND:MDM2 gene polymorphisms 285G/C and 344 T/A are two single nucleotide polymorphisms (SNPs) recently identified as important variants that could influence the expression of MDM2 gene through the modulation of transcription factors binding on the SNP309T/G. The 285C variant seems to present a geographically dis...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-11
更新日期：2014-04-07 00:00:00
abstract：:Poly(ADP-ribose) polymerases (PARPs) comprise of a large family of 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation of gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both PARP 1 and PARP 2. The...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-46
更新日期：2013-12-02 00:00:00
abstract：Background:Cervical cancer is a common cancer among women worldwide and is closely related to high-risk human papillomavirus infection (HR-HPV). The immune microenvironment is thought to play an essential role in viral infection and cancer development; however, this relationship remains controversial. Cytokines are an ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0231-z
更新日期：2019-06-28 00:00:00
abstract：BACKGROUND:Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. However, the possible role of the keystone periodontal pathogen, Porphyromonas gingivalis, in esophageal squamous cell carcinoma (ESCC) remains unknown. Therefore, we examined t...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-016-0049-x
更新日期：2016-01-19 00:00:00
abstract：OBJECTIVE:The aim of this study was to screen for the presence of Epstein Barr Virus (EBV) among Sudanese patients with Nasopharyngeal Carcinoma (NPC). METHODS:In this study, 150 tissue samples that were previously diagnosed as having NPC were screened for the presence of EBV using Polymerase Chain Reaction (PCR). PCR...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0002-4
更新日期：2015-02-17 00:00:00
abstract：BACKGROUND:The human immunodeficiency virus type 1 (HIV-1) regulatory protein, Nef, is an attractive vaccine target because it is involved in viral pathogenesis, is expressed early in the viral life cycle and harbors many T and B cell epitopes. Several clinical trials include gene-based vaccines encoding this protein. ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-14
更新日期：2007-07-10 00:00:00
abstract：BACKGROUND:Recent studies have revealed the positive antiproliferative and cytotoxic effects of antiviral agents in cancer treatment. The real effect of adjuvant antiviral therapy is still controversial due to the lack of studies in biochemical mechanisms. Here, we studied the effect of the antiviral agent acyclovir on...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-017-0128-7
更新日期：2017-03-23 00:00:00
abstract：BACKGROUND:Although the inclusion of the HPV vaccine has been registered in Spain since 2007, vaccination rates are lower than expected. The patients wish to be vaccinated is heavily influenced by information they have received from many source. The Knowledge of primary health care professionals affects the information...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-015-0034-9
更新日期：2015-11-16 00:00:00
abstract：: The eruption of Kaposi sarcoma (KS) and aggressive non-Hodgkin lymphoma (NHL) in young homosexual men in 1981 in the West heralded the onset of the human immunodeficiency virus (HIV) infection epidemic, which remains one of the biggest challenges to global public health and science ever. Because KS and NHL were incre...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-6-16
更新日期：2011-10-17 00:00:00
abstract：:Thymoquinone (TQ) is the principal active monomer isolated from the seed of the medicinal plant Nigella sativa. This compound has antitumor effects against various types of cancer including hepatocellular carcinoma (HCC), mainly due to its anti-inflammatory and anti-oxidant properties. Several pre-clinical studies sho...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-019-0226-9
更新日期：2019-04-16 00:00:00
abstract：BACKGROUND:Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in the onset of KP. METHODS:DNA from antral (n = 14) and nasal (n = 14...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-020-00342-3
更新日期：2021-01-07 00:00:00
abstract：:Bcr-Abl plays a central role in the development of chromosome positive leukaemia. Chronic Myeloid leukaemia occurs due to increase proliferation and resistance to apoptosis by Bcr-Abl positive cells. Imatinib (STI571) is the first drug in the family of Bcr-Abl tyrosine kinase inhibitors while Nilotinib (AMN107) and Da...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-23
更新日期：2013-06-20 00:00:00
abstract：:The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses,...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-8-48
更新日期：2013-12-10 00:00:00
abstract：BACKGROUND:Sexually transmitted infections (STIs) are hypothesized to play a role in the development of prostate cancer, perhaps due to inflammation-induced oncogenesis. We assessed in a nationally representative population of middle-aged men whether sexual behavior indicators for an increased risk of genital infection...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-2-19
更新日期：2007-10-24 00:00:00
abstract：BACKGROUND:To clarify the immunological alterations leading to classical Kaposi sarcoma (cKS) among people infected with KS-associated herpesvirus (KSHV). METHODS:In a population-based study of 119 cKS cases, 105 KSHV-seropositive controls, and 155 KSHV-seronegative controls, we quantified plasma soluble cluster of di...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-5-18
更新日期：2010-10-12 00:00:00
abstract：Background:Tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are recommended as the first-line choices regarding the treatment of chronic hepatits B. The impact of the two antiviral agents on prognosis of Chronic hepatitis B (CHB) related hepatocellular carcinoma (HCC) remains to be explored. We aim to investigat...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0191-8
更新日期：2018-06-08 00:00:00
abstract：BACKGROUND:The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphisms in this gene can in...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/1750-9378-9-24
更新日期：2014-07-18 00:00:00
abstract：:The evolutionarily novel genes originated through different molecular mechanisms are expressed in tumors. Sometimes the expression of evolutionarily novel genes in tumors is highly specific. Moreover positive selection of many human tumor-related genes in primate lineage suggests their involvement in the origin of new...
journal_title：Infectious agents and cancer
pub_type： 杂志文章,评审
doi：10.1186/s13027-016-0077-6
更新日期：2016-07-19 00:00:00
abstract：Background:High risk human papillomaviruses (HPVs) have been unequivocally recognised as the necessary cause of squamous intraepithelial lesions (SIL) and invasive carcinoma of the cervix. The distribution and the role of unclassified risk HPV genotypes in cervical neoplasia has not been fully elucidated. Methods:Liqu...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-018-0199-0
更新日期：2018-07-24 00:00:00
abstract：:We carried out a retrospective study on the prevalence of HPV and genotype distribution by nested PCR and nucleotide sequencing analysis, in formalin-fixed, paraffin-embedded biopsies of 135 head and neck cancers (HNC) and 29 cervical cancers received between 2009 and 2017 for diagnosis at the Laboratoire National de ...
journal_title：Infectious agents and cancer
pub_type： 杂志文章
doi：10.1186/s13027-019-0225-x
更新日期：2019-04-08 00:00:00
