Abstract:
:Lymphotoxin-beta receptor (LTbetaR) is a member of the tumor necrosis factor receptor (TNFR) superfamily that activates nuclear factor-kappaB (NF-kappaB) through the IkappaB kinase (IKK) complex, the core of which is comprised of IKK1, IKK2 and NF-kappaB essential modulator (NEMO). We demonstrate here that the LTbetaR signaling to NF-kappaB activation does not necessarily require NEMO, which is essential for TNFR signaling. In the absence of NEMO, the p50 and RelB, but not RelA subunits of NF-kappaB are found in the nuclear DNA binding complexes induced by the LTbetaR signaling. Our results thus disclose NEMO-independent NF-kappaB activation by LTbetaR.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Saitoh T,Nakano H,Yamamoto N,Yamaoka Sdoi
10.1016/s0014-5793(02)03622-0keywords:
subject
Has Abstractpub_date
2002-12-04 00:00:00pages
45-51issue
1-2eissn
0014-5793issn
1873-3468pii
S0014579302036220journal_volume
532pub_type
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