Abstract：
:Coenzymes are small organic molecules that supply a varied set of reactive groups to protein enzymes, thereby diversifying catalysis beyond the chemistries of amino acid sidechains. As RNA structures begin with a more limited chemical diversity than proteins, it seems likely that RNA enzymes would also use functional groups from other molecules to support a complex RNA world metabolism. In fact, ribonucleotide moieties in many coenzymes have long been thought to be surviving vestiges of covalently bound coenzymes in an RNA world. The idea of coenzyme utilization by ribozymes can be explored by selection-amplification of coenzyme-binding RNAs and coenzyme-assisted ribozymes. Here, we review coenzyme-RNAs, and discuss their possible significance for RNA-mediated metabolism. In summary, a plausible route from prebiotic chemistry to ribozyme biochemistry exists for CoA, and via similar activities, likely exists for all the nucleotidyl coenzymes.
journal_name
Biochimiejournal_title
Biochimieauthors
Jadhav VR,Yarus Mdoi
10.1016/s0300-9084(02)01404-9keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
877-88issue
9eissn
0300-9084issn
1638-6183pii
S0300908402014049journal_volume
84pub_type
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