Abstract:
:An immunological demonstration of alpha-fetoprotein (AFP) in uterine cytosol from immature rats is reported. The identity between serum AFP and the estrogen binding 4.5 S macromolecular complex of uterine cytosol was demonstrated by the use of a specific immunoadsorbent to AFP. Analysis of the sedimentation profile in glycerol gradients of uterine cytosol incubated with tritiated estrone or estradiol suggests that the total estrogen binding capacity of the 4.5 S complex is provided by AFP. Changes of AFP content in rat uterus with the age of the animals suggest that this protein is probably present in the cytosol as a serum contaminant.
journal_name
Biochimiejournal_title
Biochimieauthors
Aussel C,Uriel J,Michel G,Baulieu EEdoi
10.1016/s0300-9084(74)80075-1subject
Has Abstractpub_date
1974-01-01 00:00:00pages
567-70issue
4eissn
0300-9084issn
1638-6183pii
S0300-9084(74)80075-1journal_volume
56pub_type
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