Hypothesis: membrane domains and hyperstructures control bacterial division.

abstract：:Disintegrins are small non-enzymatic proteins common in the venoms of many viperid snakes. These proteins have received significant attention due to their ability to inhibit platelet aggregation and cell adhesion, making them model compounds in drug development and design investigations. The present study used a combi...

journal_title：Biochimie

authors： Saviola AJ,Modahl CM,Mackessy SP

更新日期：2015-09-01 00:00:00

abstract：:Cell walls of flocculent strains (0006) and non flocculent strains (0019) of Saccharomyces uvarum (Carlsbergensis), grown in different media and taken in both growth and stationary phases, were treated with water and with 2 per cent (W/V) potassium hydroxide. This treatment yielded four fractions (FI, FII, FIII and FR...

journal_title：Biochimie

authors： Amri MA,Bonaly R,Duteurtre B,Moll M

更新日期：1981-07-01 00:00:00

abstract：:The human liver fatty acid binding protein (hFABP1) participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in hFABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes. Gene regulation of hFABP1 is not full...

journal_title：Biochimie

authors： Wu YL,Peng XE,Wang D,Chen WN,Lin X

更新日期：2012-02-01 00:00:00

abstract：:The rate of hydrolysis of long chain triglycerides by pure bovine pancreatic lipase has been determined in the presence of variable amounts of bile salts and colipase. Cofactor-free lipase is strongly inhibited by sodium taurodesoxycholate and by mixed bovine bile salts at concentrations higher than the critical micel...

journal_title：Biochimie

authors： Rathelot J,Julien R,Canioni P,Coeroli C,Sarda L

更新日期：1975-01-01 00:00:00

abstract：:The product of the sex-determining gene SRY is a member of the HMG box containing protein superfamily. The HMG box is a DNA-binding domain of about 80 amino acids shared by many proteins with diverse functions. It seems that the functions of the full length protein are restricted to the HMG box but their molecular bas...

journal_title：Biochimie

authors： Soullier S,Poulat F,Boizet-Bonhoure B,Calas B,Bennes R,Heitz F,Berta P

更新日期：1994-01-01 00:00:00

abstract：:A synthetic phosphonate inhibitor designed for lipase inhibition but displaying a broader range of activity was covalently immobilized on a solid support to generate a function-directed tool targeting serine hydrolases. To achieve this goal, straightforward and reliable analytical techniques were developed, allowing t...

journal_title：Biochimie

authors： Delorme V,Raux B,Puppo R,Leclaire J,Cavalier JF,Marc S,Kamarajugadda PK,Buono G,Fotiadu F,Canaan S,Carrière F

更新日期：2014-12-01 00:00:00

abstract：:Oxidative stress is the main mechanism behind efficient disinfectants, causing damage in bacterial macromolecules. Importantly, bacteria activate resistance mechanisms in response to damage generated by oxidative stress. Strategies allowing pathogens to survive oxidative stress are highly conserved among microorganism...

journal_title：Biochimie

authors： Cabezas CE,Laulié AM,Briones AC,Pardo-Esté C,Lorca DE,Cofré AA,Morales EH,Mora AY,Krüger GI,Bueno SM,Hidalgo AA,Saavedra CP

更新日期：2021-01-01 00:00:00

abstract：:The regulation of transcription of the pckA gene coding for phosphoenolpyruvate carboxykinase in Escherichia coli was analysed by site-directed mutagenesis of the promoter region and measurement of in vitro transcription initiation. Mutation of the guanine residue at position -14 to either cytosine or thymine was foun...

journal_title：Biochimie

authors： Prost JF,Cozzone AJ

更新日期：1999-03-01 00:00:00

abstract：:The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic index and increased toxicity profile. Hence, there still exists ample opportunity to discover safe and effective anti...

journal_title：Biochimie

authors： Singh M,Malhotra L,Haque MA,Kumar M,Tikhomirov A,Litvinova V,Korolev AM,Ethayathulla AS,Das U,Shchekotikhin AE,Kaur P

更新日期：2021-01-06 00:00:00

abstract：:Bothropstoxin-I (BthTx-I) is a homodimeric Lys49-PLA2 from the venom of the snake Bothrops jararacussu, which lacks hydrolytic activity against phospholipid substrates, yet permeabilizes membranes by a Ca2+-independent mechanism. The interaction of the BthTx-I with model membranes has been studied by intrinsic tryptop...

journal_title：Biochimie

authors： Ferreira TL,Ruller R,Chioato L,Ward RJ

更新日期：2008-09-01 00:00:00

abstract：:Polysialylated neural cell adhesion molecule (NCAM) was immunoaffinity-purified from the brains of newborn calves. A degree of polymerization of up to 40 was chromatographically determined for released polysialic acid (PSA) chains. For characterization of N-glycan structures and attachment sites, PSA-NCAM was digested...

journal_title：Biochimie

authors： Wuhrer M,Geyer H,von der Ohe M,Gerardy-Schahn R,Schachner M,Geyer R

更新日期：2003-01-01 00:00:00

abstract：:The misfolding of amyloid proteins is closely correlated with the pathogenesis of protein conformation-related diseases, such as Alzheimer's disease (AD), prion disease, and type 2 diabetes mellitus (T2DM). The deposition of human islet amyloid polypeptide (hIAPP) and amyloid-β (Aβ) protein is entangled in AD and diab...

journal_title：Biochimie

authors： Xu J,Zhao C,Huang X,Du W

更新日期：2020-07-01 00:00:00

abstract：:The hypothesis is proposed that pre-biotic bacterial cell(s) and the first cells capable of growth/division did not require a cytoplasmic membrane. A gel-like microscopic structure less than a cubic micrometer may have had a dual role as both an ancient pre-cytoplasm and a boundary layer to the higher-entropy external...

journal_title：Biochimie

authors： Trevors JT,Pollack GH

更新日期：2012-01-01 00:00:00

abstract：:This review article outlines some potentials and limits of the recent application of high resolution Nuclear Magnetic Resonance technique--coupled to the Fourier transformation methods--to the study of biological membranes. Molecular arrangement and dynamical structure characters can be assessed at the level of indivi...

journal_title：Biochimie

authors： Podo F

更新日期：1975-01-01 00:00:00

abstract：:The proton NMR data of a synthetic model of deoxy-myoglobin and hemoglobin show one that:(i) the ground state of the high spin iron (II) complex must be described by at least two electronic levels separated by ca.200 cm-1 and resulting from the removal of the degeneracy of the 5E level; (ii) this in-plane rhombic dist...

journal_title：Biochimie

authors： Mispelter J,Momenteau M,Lhoste JM

更新日期：1981-11-01 00:00:00

abstract：:Ceramidase plays an important role in regulating the metabolism of sphingolipids, such as ceramide, sphingosine (SPH), and sphingosine-1-phosphate (S1P), by controlling the hydrolysis of ceramide. Here we report the cloning and biochemical characterization of a neutral ceramidase from the red flour beetle Tribolium ca...

journal_title：Biochimie

authors： Zhou Y,Lin XW,Yang Q,Zhang YR,Yuan JQ,Lin XD,Xu R,Cheng J,Mao C,Zhu ZR

更新日期：2011-07-01 00:00:00

abstract：:The widespread nature of protein phosphorylation/dephosphorylation underscores its key role in cell signaling metabolism, growth and differentiation. Tyrosine phosphorylation of cytoplasmic proteins is a critical event in the regulation of intracellular signaling pathways activated by external stimuli. An adequate bal...

journal_title：Biochimie

authors： Zambuzzi WF,Milani R,Teti A

更新日期：2010-04-01 00:00:00

abstract：:In the present study we have investigated the thermal stability of the globular transport protein human serum albumin (HSA), in the presence of two small chain polyethylene glycols (namely PEG 200 and PEG 400). Both near- and far-UV circular dichroism (CD) study reveal that addition of PEG moderately increases the α-h...

journal_title：Biochimie

authors： Samanta N,Mahanta DD,Hazra S,Kumar GS,Mitra RK

更新日期：2014-09-01 00:00:00

abstract：:Knowing the structure of a protein is essential to characterize its function and mechanism at the molecular level. Despite major advances in solving structures experimentally, most membrane protein native conformations remain unknown. This lack of available structures, along with the physical constraints imposed by th...

journal_title：Biochimie

authors： Postic G,Ghouzam Y,Gelly JC

更新日期：2015-08-01 00:00:00

abstract：:RNA domain swapping typically demonstrates conservation of the native function of the domain in a non-native context. In contrast, we employed RNA engineering to demonstrate deviation of G-quadruplex (GQ) function that is contingent upon its context dependent location, which is opposite to their native functional role...

journal_title：Biochimie

authors： Bhattacharyya D,Morris MJ,Kharel P,Mirihana Arachchilage G,Fedeli KM,Basu S

更新日期：2017-06-01 00:00:00

abstract：:The single channel data for 4 different linear gramicidins containing either 4 Trp, 4 Phe, 4 Tyr or TyrBzl have been analyzed on the basis of 3 barriers-2 sites model. They form 2 families which differ by their single channel behavior and thus different energy profiles of the channel. A relationship between the surfac...

journal_title：Biochimie

authors： Heitz F,Van Mau N,Bennes R,Daumas P,Trudelle Y

更新日期：1989-01-01 00:00:00

abstract：:Nephropathy is one of the most frequent complications of chronic diabetes. The main reason for nephropathy despite being hyperglycemia, but it progresses even after good glycemic control has been achieved in diabetic patients. The effects of prior exposure to high blood glucose conditions depend upon the severity and ...

journal_title：Biochimie

authors： Kushwaha K,Sharma S,Gupta J

更新日期：2020-03-01 00:00:00

abstract：:Leptin is a cytokine secreted by the adipose tissue that is involved in the control of body weight. We previously showed that a point mutation (R105W) in leptin results in leptin deficiency, marked obesity and hypogonadism in humans adults. Expression in COS1 cells showed impaired secretion and intracellular accumulat...

journal_title：Biochimie

authors： Boute N,Zilberfarb V,Camoin L,Bonnafous S,Le Marchand-Brustel Y,Issad T

更新日期：2004-06-01 00:00:00

abstract：:The structure difference between the free operator of the lac system d(GCTCACAAT).d(ATTGTGAGC) and the same operator complexed to the headpiece of the lac repressor has been investigated by 2-D-1H NMR spectroscopy in conjunction with molecular modelling in internal coordinates (JUMNA). The free and complexed operator ...

journal_title：Biochimie

authors： Gincel E,Lancelot G,Maurizot JC,Thuong NT,Vovelle F

更新日期：1994-01-01 00:00:00

abstract：:LamB, an integral outer membrane protein of E coli K12, is highly resistant to protease digestion. We had previously genetically inserted a foreign sequence corresponding to an epitope from the poliovirus next to amino acids 146, 153, 189, and 374 of LamB. In 3 cases (sites 146, 153, 374), insertion of the foreign pep...

journal_title：Biochimie

authors： Ronco J,Charbit A,Hofnung M

更新日期：1990-02-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-infected cells actively release the transcriptional activator (Tat) viral protein that is required for efficient HIV gene transcription. Extracellular Tat is able to enter uninfected cells. We recently reported that internalized Tat escapes endosomes to reach the cytosol and is then ...

journal_title：Biochimie

authors： Beaumelle B,Tóth P,Malak OA,Chopard C,Loussouarn G,Vitale N

更新日期：2017-10-01 00:00:00

abstract：:Lipolytic activities of Yarrowia lipolytica LIP2 lipase (YLLIP2), human pancreatic (HPL) and dog gastric (DGL) lipases were first compared using lecithin-stabilized triacylglycerol (TAG) emulsions (Intralipid) at various pH and bile salt concentrations. Like DGL, YLLIP2 was able to hydrolyze TAG droplets covered by a ...

journal_title：Biochimie

authors： Bénarouche A,Point V,Carrière F,Cavalier JF

更新日期：2014-07-01 00:00:00

abstract：:The potent cytotoxicity of reactive oxygen species (ROS) can cause various diseases, however, it may also serve as a powerful chemotherapeutic strategy capable of killing cancer cells. Oxalomalate (OMA, α-hydroxy-β-oxalosuccinic acid), a tricarboxylic acid intermediate, is a well-known competitive inhibitor of two cla...

journal_title：Biochimie

authors： Kim SH,Kil IS,Kwon OS,Kang BS,Lee DS,Lee HS,Lee JH,Park JW

更新日期：2019-03-01 00:00:00

abstract：:A depletion in long-chain polyunsaturated omega3 fatty acids may affect fuel homeostasis. In such a perspective, the present study deals mainly with the in vitro fate of D-[U-(14)C]glucose in hemidiaphragms, stretched soleus and plantaris muscle pieces obtained from normal and omega3-depleted rats (second generation) ...

journal_title：Biochimie

authors： Agascioglu E,Zhang Y,Sener A,Portois L,Chardigny JM,Malaisse WJ,Carpentier YA

更新日期：2007-03-01 00:00:00

abstract：:During clinical trials, a number of fully characterized molecules are dropped along the way because they do not provide enough benefit for the patient. Some of them show limited side effects and might be of great use for other applications. AS1411 is a nucleolin-targeting aptamer that underwent phase II clinical trial...

journal_title：Biochimie

authors： Métifiot M,Amrane S,Mergny JL,Andreola ML

更新日期：2015-11-01 00:00:00