Abstract：
:Trypsin and pronase treatment of purified human neutral bronchial mucins released small fragments from the C-terminal end of these molecules and resulted in slight increases in their sedimentation coefficient presumably reflecting conformational changes. The antigenic determinant of neutral bronchial mucins which appears to be located on this C-terminal fragment is destroyed by pronase or by treatments such as periodate oxidation or galactose oxidase-bromine oxidation which modify the carbohydrate moieties. Thus, both amino acid and carbohydrate residues are involved in the structure of the antigenic determinant.
journal_name
Biochimiejournal_title
Biochimieauthors
Lhermitte M,Lambin G,Lafitte JJ,Rousseau J,Degand P,Roussel Pdoi
10.1016/s0300-9084(76)80444-0subject
Has Abstractpub_date
1976-01-01 00:00:00pages
367-72issue
3eissn
0300-9084issn
1638-6183pii
S0300-9084(76)80444-0journal_volume
58pub_type
杂志文章相关文献
BIOCHIMIE文献大全abstract：:We have analyzed the interference of antitumoral drugs acting through the inhibition of DNA topoisomerase II on the human HeLa cell metabolism. Different compounds characterized by a diverse mechanism of action have been used, namely m-amsacrine, an intercalative drug, etoposide, which does not intercalate DNA, and su...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(95)90009-8
更新日期：1995-01-01 00:00:00
abstract：:Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that process growth factors, growth factor binding proteins, cell surface proteins, degrade extracellular matrix (ECM) components and thereby play a central role in tissue remodeling and tumor progression. Membrane-type matrix metalloproteinases (MT-...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2004.07.012
更新日期：2005-03-01 00:00:00
abstract：:Pseudouridine [Ψ] is a frequent base modification in the ribosomal RNA [rRNA] and may be involved in the modulation of the conformational flexibility of rRNA helix-loop structures during protein synthesis. Helix 69 of 23S rRNA contains pseudouridines at the positions 1911, 1915 and 1917 which are formed by the helix 6...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.12.018
更新日期：2011-05-01 00:00:00
abstract：:Personalized and regenerative medicine is an emerging therapeutic strategy that is based on cell biology and biomedical engineering used to develop biological substitutes to maintain normal function or restore damaged tissues and organs. The secretory capacities of different cell types are now explored as such possibl...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2018.04.015
更新日期：2018-12-01 00:00:00
abstract：:In the present study we have investigated the thermal stability of the globular transport protein human serum albumin (HSA), in the presence of two small chain polyethylene glycols (namely PEG 200 and PEG 400). Both near- and far-UV circular dichroism (CD) study reveal that addition of PEG moderately increases the α-h...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.05.009
更新日期：2014-09-01 00:00:00
abstract：:The proximity of cerebrospinal fluid (CSF) with the brain, its permanent renewal and better availability for research than tissue biopsies, as well as ganglioside (GG) shedding from brain to CSF, impelled lately the development of protocols for the characterization of these glycoconjugates and discovery of central ner...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2019.12.008
更新日期：2020-03-01 00:00:00
abstract：:Two soluble forms of brain glutamate dehydrogenase isoproteins were inactivated by pyridoxal 5'-phosphate. Restoration of catalytic activity can be accomplished by dialysis and addition of an excess of cysteine or lysine. Spectral evidence is presented to indicate that the inactivation proceeds through Schiff base for...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(97)84333-7
更新日期：1996-01-01 00:00:00
abstract：:Pulmonary fibrosis (PF) is a progressive lethal disorder. In this study, the effect of daidzein, a soyisoflavone against Bleomycin (BLM) induced PF in rats was elucidated. A single intratracheal instillation of BLM (3 U/kg.bw) was administered in rats to induce PF. Daidzein (0.2 mg/kg) was administered subcutaneously,...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.04.005
更新日期：2014-08-01 00:00:00
abstract：:Sm and Sm-like (Lsm) proteins are considered as an evolutionary conserved family involved in RNA metabolism in organisms from bacteria and archaea to human. Currently, the function of Sm-like archaeal proteins (SmAP) is not well understood. Here, we report the crystal structures of SmAP proteins from Sulfolobus acidoc...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.05.001
更新日期：2020-08-01 00:00:00
abstract：:A lignin model compound, named in short guaiagylglycerol beta-guaiacyl ether (GGE), contains the beta-0-4 ether linkage that is common in the chemical structure of lignin. A Pseudomonas sp. (GU5) had been isolated as an organism able to grow with GGE as the sole source of carbon and energy. When grown on vanillate, th...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(85)80292-3
更新日期：1985-09-01 00:00:00
abstract：:Secondary structure-forming DNA motifs have achieved infamy because of their association with a variety of human diseases and cancer. The 3rd FASEB summer conference on dynamic DNA structures focused on the mechanisms responsible for the instabilities inherent to repetitive DNA and presented many exciting and novel as...
journal_title：Biochimie
pub_type：
doi：10.1016/j.biochi.2012.10.005
更新日期：2013-02-01 00:00:00
abstract：:Multiple forms of acetylcholinesterase have been studied in Goldfish adapted to 15 degrees C and 25 degrees C. Three forms of enzyme (sedimenting at 18S, 12S and 5S) could be distinguished by sucrose gradient centrifugation. Their molecular and enzymatic properties did not vary with environmental temperature. It was n...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(76)80257-x
更新日期：1976-01-01 00:00:00
abstract：:A methylene group of camphor is hydroxylated by a P450 monoxygenase system containing in addition to the cytochrome and flavoprotein dehydrogenase a two-iron, two-sulfur redox protein termed putidaredoxin. The regulatory control of electron transport equilibrium occurs via ligation of substrate and redoxin to the cyto...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(76)80364-1
更新日期：1976-01-01 00:00:00
abstract：:It is now over 10 years since the discovery of peroxisome proliferator activated receptor gamma (PPAR gamma) and its unique role in adipogenesis. The subsequent identification of PPAR gamma as the target of insulin sensitizing drugs certified this ligand-regulated transcription factor as an exciting link between adipo...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2004.10.021
更新日期：2005-01-01 00:00:00
abstract：:A HU-like protein (HBl) of Bifidobacterium longum was purified and characterized. HBl is heat-stable and acid-resistant, and has a molecular weight of about 9.1 kDa as estimated by its mobility on electrophoresis. HBl is intermediate in basicity (pI 9.8) between the HU-1 and HU-2 proteins of Escherichia coli, and is d...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(90)90074-q
更新日期：1990-04-01 00:00:00
abstract：:We have studied through the late foetal period of the rat, the evolution of two enzymes involved in glycogen metabolism of the liver : UDPG glycogen synthetase (a and b forms) and branching enzyme. The activities were measured during the development of normal foetuses and of foetuses experimentally deprived of cortico...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(75)80140-4
更新日期：1975-01-01 00:00:00
abstract：:Cell walls of flocculent strains (0006) and non flocculent strains (0019) of Saccharomyces uvarum (Carlsbergensis), grown in different media and taken in both growth and stationary phases, were treated with water and with 2 per cent (W/V) potassium hydroxide. This treatment yielded four fractions (FI, FII, FIII and FR...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(81)80055-7
更新日期：1981-07-01 00:00:00
abstract：:Split luciferase complementary assay has been used to investigate the effect of WD domain deletion on Apaf-1 oligomerization. Apaf-1 is an adaptor molecule in formation of apoptosome that activates caspase-9, an activation that is a key event in the mitochondrial cell death pathway. Structural studies suggest that nor...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.10.013
更新日期：2021-01-01 00:00:00
abstract：:Evidence from clinical, animal and cell culture studies demonstrates that increased autotaxin (ATX) expression is responsible for enhancing tumor progression, cell migration, metastases, angiogenesis and chemo-resistance. These effects depend mainly on the rapid formation of lysophosphatidate (LPA) by ATX. Circulating...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2010.08.002
更新日期：2011-01-01 00:00:00
abstract：:Unspliced human immunodeficiency virus-1 (HIV-1) mRNA is capped and therefore can be translated via conventional scanning mechanism. In addition, its 5' untranslated region (5'UTR) is thought to function as an internal ribosome entry site (IRES) during G2/M-phase of cell cycle or when cap-dependent translation is inhi...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:The kinetoplastid protozoan Leishmania encodes major surface glycoprotein GP63, a zinc metallo-peptidase (EC.3.4.24.36) expressed both in promastigote and amastigote life stages. In the present study, we explored for the first time the role of C-terminal domain (CTD) in proteinase activity by serial truncation of Leis...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.07.014
更新日期：2010-12-01 00:00:00
abstract：:The human liver fatty acid binding protein (hFABP1) participates in cellular long-chain fatty acid trafficking and regulation of lipid metabolism and changes in hFABP1 are associated with an increased risk for type 2 diabetes, cardiovascular disease (CVD), and metabolic syndromes. Gene regulation of hFABP1 is not full...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.08.006
更新日期：2012-02-01 00:00:00
abstract：:Here we report two novel 17-mer amidated linear peptides (TsAP-1 and TsAP-2) whose structures were deduced from cDNAs cloned from a venom-derived cDNA library of the Brazilian yellow scorpion, Tityus serrulatus. Both mature peptides were structurally-characterised following their location in chromatographic fractions ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2013.06.003
更新日期：2013-09-01 00:00:00
abstract：:Simian Virus 40 (SV40) DNA replication was studied in vitro using cell free extracts prepared from SV40 infected CV1 cells. The cells were fractionated into a soluble cytoplasmic fraction and nuclei. The nuclei were lysed with high salt and used to prepare a soluble nuclear fraction. Both fractions displayed DNA polym...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(76)80088-0
更新日期：1976-11-13 00:00:00
abstract：:We describe a method to compare two fluorescence anisotropy decay curves. After numerical deconvolution of both decays by a non a priori method [1], their difference, D, is considered. The variance is computed for each point of D. A confidence interval is defined which allows a decision to be made as to the significan...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(84)90117-2
更新日期：1984-09-01 00:00:00
abstract：:Contradictory results for concentrations of vitamin B12, holotranscobalamin (holoTC), and methylmalonic acid (MMA) have been reported. We tested the hypothesis that the extracellular vitamin B12 markers are not reflecting the intracellular vitamin B12-dependent biochemical reactions in individuals with type 2 diabetes...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2012.10.028
更新日期：2013-05-01 00:00:00
abstract：:The automation of the mica surface displacement of a surface force apparatus (SFA) increases the accuracy of the intermolecular force measurements that is obtained without the presence of the experimenter. The automatic device cancels any thermal drift and the stability of the mica surfaces is optimum. The distance be...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(00)80007-3
更新日期：1998-05-01 00:00:00
abstract：:Adipose tissue lipoprotein lipase activity (LPL) falls dramatically during experimental infection of mice by Plasmodium chabaudi. The decrease in this activity accounts for the seric accumulation of triacyl-glyceride-rich lipoproteins (chylomicrons mainly and Very Low Density Lipoproteins (VLDL) partly). This loss of ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(82)80414-8
更新日期：1982-02-01 00:00:00
abstract：:The effect of adenosine was tested on the energetic metabolism of fed rat liver cells after isolation. The cells were incubated in a buffered saline medium with glucose (5 mM) and adenosine (1 mM) for 30 minutes at 37 degrees C. This increased the concentration of the adenylic nucleotides ATP (+57 per cent, ADP (+39 p...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(80)80286-0
更新日期：1979-01-01 00:00:00
abstract：:Honeybee-plant relationships are based on a conditioning process in which olfactory (plant aroma) and gustatory cues (mainly nectars) are closely linked, leading to a selective foraging behaviour. Among crops dependent upon entomophilous cross-pollination, the sunflower has recently undergone extensive expansion due t...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(87)90186-6
更新日期：1987-06-01 00:00:00
