When secondary comes first--the importance of non-canonical DNA structures.

Abstract:

:Secondary structure-forming DNA motifs have achieved infamy because of their association with a variety of human diseases and cancer. The 3rd FASEB summer conference on dynamic DNA structures focused on the mechanisms responsible for the instabilities inherent to repetitive DNA and presented many exciting and novel aspects related to the metabolism of secondary structures. In addition, the meeting encompassed talks and posters on the dynamic structures that are generated during DNA metabolism including nicked DNA, Holliday junctions and RNA:DNA hybrids. New approaches for analysis and sequencing technologies put forth secondary structures and other DNA intermediates as vital regulators of a variety of cellular processes that contribute to evolution, polymorphisms and diseases.

journal_name

Biochimie

journal_title

Biochimie

authors

Saini N,Zhang Y,Usdin K,Lobachev KS

doi

10.1016/j.biochi.2012.10.005

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

117-23

issue

2

eissn

0300-9084

issn

1638-6183

pii

S0300-9084(12)00405-1

journal_volume

95

pub_type

  • Subcellular localization and self-interaction of plant-specific Nt-4/1 protein.

    abstract::The Nicotiana tabacum Nt-4/1 protein is a plant-specific protein of unknown function. Analysis of bacterially expressed Nt-4/1 protein in vitro revealed that the protein secondary structure is mostly alpha-helical and suggested that it could consist of three structural domains. Earlier studies of At-4/1, the Arabidops...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2013.02.015

    authors: Solovyev AG,Minina EA,Makarova SS,Erokhina TN,Makarov VV,Kaplan IB,Kopertekh L,Schiemann J,Richert-Pöggeler KR,Morozov SY

    更新日期:2013-07-01 00:00:00

  • Biotechnology tools and applications for development of oilseed crops with healthy vegetable oils.

    abstract::Vegetable oils, consisting principally of triacylglycerols (TAG), are major sources of calories and essential fatty acids in the human diet. The fatty acid composition of TAG is a primary determinant of the nutritional quality and health-promoting properties of vegetable oils. TAG fatty acid composition also affects t...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2020.09.020

    authors: Msanne J,Kim H,Cahoon EB

    更新日期:2020-11-01 00:00:00

  • Dietary choline is related to increased risk of acute myocardial infarction in patients with stable angina pectoris.

    abstract::High plasma choline has been associated with the metabolic syndrome and risk of chronic diseases, including cardiovascular disease. However, dietary choline is not correlated with choline plasma concentrations, and there are few studies and contradictory evidence regarding dietary choline and cardiovascular events. In...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2019.11.001

    authors: Van Parys A,Lysne V,Svingen GFT,Ueland PM,Dhar I,Øyen J,Dierkes J,Nygård OK

    更新日期:2020-06-01 00:00:00

  • Alterations of endogenous sphingolipid metabolism in cardiometabolic diseases: Towards novel therapeutic approaches.

    abstract::The increasing prevalence of obesity and metabolic diseases is a worldwide public health concern, and the advent of new analytical technologies has made it possible to highlight the involvement of some molecules, such as sphingolipids (SL), in their pathophysiology. SL are constituents of cell membranes, lipoproteins ...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2019.10.003

    authors: Le Barz M,Boulet MM,Calzada C,Cheillan D,Michalski MC

    更新日期:2020-02-01 00:00:00

  • Effect of genetic and physiological manipulations onthe kinetic and binding parameters of the adenine nucleotide translocator in Saccharomyces cervisiae and Candida utilis.

    abstract::1. Ghe kinetic and binding parameters of adenine-nucleotide transport have been studied in mitochondria isolated from yeast cells in which the mitochondrial protein-synthetizing system had been inhibited by growth in the presence of erythromycin. These parameters have also been studied in promitochondria isolated from...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/s0300-9084(76)80120-4

    authors: Lauquin G,Lunardi J,Vignais PV

    更新日期:1976-01-01 00:00:00

  • Fate of mRNA extremities generated by intrinsic termination: detailed analysis of reactions catalyzed by ribonuclease II and poly(A) polymerase.

    abstract::In all living cells 3' ends of RNA are posttranscriptionally elongated or shortened by nucleotidyl transferases and ribonucleases. The detailed analysis of the rpsO mRNA of Escherichia coli presented here demonstrates that transcription terminates in vivo at two sites located seven and eight nucleotides downstream fro...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2005.02.012

    authors: Folichon M,Marujo PE,Arluison V,Le Derout J,Pellegrini O,Hajnsdorf E,Régnier P

    更新日期:2005-09-01 00:00:00

  • Hormonal regulation of liver phosphoenolpyruvate carboxykinase and glucokinase gene expression at weaning in the rat.

    abstract::During the suckling period, the rats are fed continuously with milk, which is a high-fat low-carbohydrate diet (HF). At weaning, milk is progressively replaced by the rat's laboratory chow which is a high-carbohydrate low-fat diet (HCHO), and this is accompanied by large hormonal modifications: an increase in plasma i...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/0300-9084(91)90077-e

    authors: Girard J,Perdereau D,Narkewicz M,Coupé C,Ferré P,Decaux JF,Bossard P

    更新日期:1991-01-01 00:00:00

  • Dynamic expression of novel and conserved microRNAs and their targets in diploid and tetraploid of Paulownia tomentosa.

    abstract::MicroRNAs (miRNAs) play profound roles in plant growth and development by regulating gene expression. Tetraploid plants often have better physical characteristics and stress tolerance than their diploid progenitors, but the role of miRNAs in this superiority is unclear. Paulownia tomentosa, (Paulowniaceae) is attracti...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2014.02.008

    authors: Fan G,Zhai X,Niu S,Ren Y

    更新日期:2014-07-01 00:00:00

  • Evidence for a phosphoenolpyruvate dependent sugar-phosphotransferase system in the mollicute Acholeplasma florum.

    abstract::In order to confirm the presence of a phosphoenolpyruvate (PEP)-dependent sugar-phosphotransferase system (PTS) in the mollicute Acholeplasma florum we studied the ability of cell free extracts of this organism to phosphorylate glucose and/or fructose in the presence of PEP. We also cloned and sequenced a DNA fragment...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/0300-9084(93)90098-d

    authors: Navas-Castillo J,Laigret F,Hocquellet A,Chang CJ,Bove JM

    更新日期:1993-01-01 00:00:00

  • Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase.

    abstract::Endothelial nitric oxide synthase (eNOS) plays a crucial role in the regulation of a variety of cardiovascular functions. Many studies have shown that dietary n-3 polyunsaturated fatty acids (PUFAs) have beneficial effects on coronary atherosclerosis. However, the mechanisms of n-3 PUFAs regulation in eNOS activation ...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2006.10.009

    authors: Li Q,Zhang Q,Wang M,Zhao S,Ma J,Luo N,Li N,Li Y,Xu G,Li J

    更新日期:2007-01-01 00:00:00

  • High altitude mediated skeletal muscle atrophy: Protective role of curcumin.

    abstract::Chronic hypobaric hypoxia induced muscle atrophy results in decreased physical performance at high altitude. Curcumin has been shown to have muscle sparing effects under cachectic conditions. However, the protective effects of curcumin under chronic hypobaric hypoxia have not been studied till now. Therefore, the pres...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2018.10.012

    authors: Chaudhary P,Sharma YK,Sharma S,Singh SN,Suryakumar G

    更新日期:2019-01-01 00:00:00

  • May omega-3 fatty acid dietary supplementation help reduce severe complications in Covid-19 patients?

    abstract::In around 10% of SARS-CoV-2 infected patients, coronavirus disease-2019 (Covid-19) symptoms are complicated with a severe lung damage called Acute Respiratory Distress Syndrome (ARDS), which is often lethal. ARDS is mainly associated with an uncontrolled overproduction of immune cells and cytokines, called "cytokine s...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2020.09.003

    authors: Weill P,Plissonneau C,Legrand P,Rioux V,Thibault R

    更新日期:2020-12-01 00:00:00

  • Dose-response estrogen promotes osteogenic differentiation via GPR40 (FFAR1) in murine BMMSCs.

    abstract::Estrogen plays an essential role in bone formation, and estrogen modulation dysfunction is tightly associated with postmenopausal osteoporosis (PMOP). The underlying mechanisms of estrogen-mediated osteogenic differentiation have not been well defined. In this study, murine bone marrow mesenchymal stem cells were indu...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2015.01.001

    authors: Gao B,Huang Q,Jie Q,Wang L,Zhang HY,Liu J,Yang L,Luo ZJ

    更新日期:2015-03-01 00:00:00

  • Antioxidant and antitumor activities of 4-arylcoumarins and 4-aryl-3,4-dihydrocoumarins.

    abstract::Five 4-arylcoumarins (1c-g) and twelve 3,4-dihydro-4-arylcoumarins (2a-l) were synthesized and tested for antioxidant activity, antitumor activity, toxicity and structure-activity relationships analysis. 4-Arylcoumarins and 3,4-dihydro-4-arylcoumarins that possess two hydroxyl groups in ortho position, such as 1d, 1f,...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2014.03.014

    authors: Zhang K,Ding W,Sun J,Zhang B,Lu F,Lai R,Zou Y,Yedid G

    更新日期:2014-12-01 00:00:00

  • Distinct functional properties of secretory l-asparaginase Rv1538c involved in phagosomal survival of Mycobacterium tuberculosis.

    abstract::The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) stains has escalated the need for developing more efficient drugs and therapeutic strategies against tuberculosis. Here we functionally annotate a secretory mycobacterial asparaginase Rv1538c (MtA) and describe its biochemical properties. MtA primarily e...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2020.12.023

    authors: Kataria A,Patel AK,Kundu B

    更新日期:2021-01-05 00:00:00

  • MicroRNA-149 is associated with clinical outcome in human neuroblastoma and modulates cancer cell proliferation through Rap1 independent of MYCN amplification.

    abstract:PURPOSE:We evaluated the clinical relevance of microRNA-149 (miR-149) in neuroblastoma (NB) and its functional roles in regulating NB proliferation in vitro. METHODS:QRT-PCR was used to evaluate miR-149 expression in NB cell lines and primary NB tumors. Association between endogenous miR-149 expression in primary NB t...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2017.04.011

    authors: Xu Y,Chen X,Lin L,Chen H,Yu S,Li D

    更新日期:2017-08-01 00:00:00

  • Protein engineering of ribonucleases.

    abstract::Natural bovine seminal RNase possesses a potent antitumor action. We have mutagenized monomeric bovine pancreatic RNase A, devoid of any cytotoxic action, to insert residues present at corresponding positions in the subunit of dimeric, antitumor, seminal RNase. Like naturally dimeric seminal RNase, the mutant dimeric ...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/s0300-9084(00)88887-2

    authors: Cafaro V,Bracale A,Formiggini F,Notomista E,D'Alessio G,Di Donato A

    更新日期:1998-11-01 00:00:00

  • Therapeutic potential of Mediator complex subunits in metabolic diseases.

    abstract::The multisubunit Mediator is an evolutionary conserved transcriptional coregulatory complex in eukaryotes. It is needed for the transcriptional regulation of gene expression in general as well as in a gene specific manner. Mediator complex subunits interact with different transcription factors as well as components of...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2017.10.012

    authors: Ranjan A,Ansari SA

    更新日期:2018-01-01 00:00:00

  • lncRNA in the liver: Prospects for fundamental research and therapy by RNA interference.

    abstract::Long non-coding RNAs constitute the most abundant part of the transcribed mammalian genome. lncRNAs affect all essential processes in the living cell including transcription, splicing, translation, replication, shaping of chromatin and post translational modification of proteins. Alterations in lncRNA expression have ...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2016.06.007

    authors: Smekalova EM,Kotelevtsev YV,Leboeuf D,Shcherbinina EY,Fefilova AS,Zatsepin TS,Koteliansky V

    更新日期:2016-12-01 00:00:00

  • The human testis determining factor SRY: a new member of the HMG box protein family.

    abstract::The product of the sex-determining gene SRY is a member of the HMG box containing protein superfamily. The HMG box is a DNA-binding domain of about 80 amino acids shared by many proteins with diverse functions. It seems that the functions of the full length protein are restricted to the HMG box but their molecular bas...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/0300-9084(94)90033-7

    authors: Soullier S,Poulat F,Boizet-Bonhoure B,Calas B,Bennes R,Heitz F,Berta P

    更新日期:1994-01-01 00:00:00

  • On remaining cytoplasmic.

    abstract::The published literature contains a number of examples of normally non-cytoplasmic proteins whose transport out of the cytoplasm is not completely abolished by drastic alterations to their routing signals (signal sequences, etc). Furthermore, there are numerous examples of cytoplasmic proteins that can be routed to an...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/0300-9084(90)90133-2

    authors: Pugsley AP

    更新日期:1990-02-01 00:00:00

  • Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.

    abstract::Triple-negative breast cancer (TNBC) is a heterogeneous group of breast cancer with one common feature: distinctly metastatic nature with higher rate of relapse and shorter survival compared with other subtypes of breast cancer. The epithelial to mesenchymal transition (EMT) is highly associated with cancer metastasis...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2019.03.004

    authors: Liang L,Liu X,He J,Shao Y,Liu J,Wang Z,Xia L,Han T,Wu P

    更新日期:2019-07-01 00:00:00

  • Study of the behavior of biological molecules in a thin gap by refractive index and force measurements with an automatic surface force apparatus.

    abstract::The automation of the mica surface displacement of a surface force apparatus (SFA) increases the accuracy of the intermolecular force measurements that is obtained without the presence of the experimenter. The automatic device cancels any thermal drift and the stability of the mica surfaces is optimum. The distance be...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/s0300-9084(00)80007-3

    authors: Gauthier-Manuel B,Gallinet JP

    更新日期:1998-05-01 00:00:00

  • Specificity characterization of the α-mating factor hormone by Kex2 protease.

    abstract::Kex2 is a Ca2+-dependent serine protease from S. cerevisiae. Characterization of the substrate specificity of Kex2 is of particular interest because this protease serves as the prototype of a large family of eukaryotic subtilisin-related proprotein-processing proteases that cleave sites consisting of pairs or clusters...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2016.10.003

    authors: Manfredi MA,Antunes AA,Jesus LO,Juliano MA,Juliano L,Judice WA

    更新日期:2016-12-01 00:00:00

  • Iron increases liver injury through oxidative/nitrative stress in diabetic rats: Involvement of nitrotyrosination of glucokinase.

    abstract::Excessive tissue iron levels are associated with the increase of oxidative/nitrative stress which contributes to tissue damage that may elevate the risk of diabetes. Therefore, we investigated the effects of iron on diabetes-associated liver injury and whether iron-related tyrosine nitration participated in this proce...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2012.07.019

    authors: Li X,Li H,Lu N,Feng Y,Huang Y,Gao Z

    更新日期:2012-12-01 00:00:00

  • Human mismatch repair, drug-induced DNA damage, and secondary cancer.

    abstract::DNA mismatch repair (MMR) is an important replication error avoidance mechanism that prevents mutation. The association of defective MMR with familial and sporadic gastrointestinal and endometrial cancer has been acknowledged for some years. More recently, it has become apparent that MMR defects are common in acute my...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/j.biochi.2003.10.007

    authors: Karran P,Offman J,Bignami M

    更新日期:2003-11-01 00:00:00

  • Mapping the eosinophil cationic protein antimicrobial activity by chemical and enzymatic cleavage.

    abstract::The eosinophil cationic protein (ECP) is a human antimicrobial protein involved in the host immune defense that belongs to the pancreatic RNase A family. ECP displays a wide range of antipathogen activities. The protein is highly cationic and its bactericidal activity is dependant on both cationic and hydrophobic surf...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/j.biochi.2010.10.005

    authors: Sánchez D,Moussaoui M,Carreras E,Torrent M,Nogués V,Boix E

    更新日期:2011-02-01 00:00:00

  • Polyphosphate as a source of phosphoryl group in protein modification in the archaebacterium Sulfolobus acidocaldarius.

    abstract::The incubation of polyphosphates with the ribosomal fraction of Sulfolobus acidocaldarius leads to the covalent attachment of phosphate to threonine residue(s) of a single 40,000 Mr protein. The hydrolysis kinetics of this protein showed that polyphosphate might be the modifying group. The reaction requires 2 mM Mn2+ ...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/0300-9084(89)90115-6

    authors: Skorko R

    更新日期:1989-09-01 00:00:00

  • Conformational dynamics and enzyme activity.

    abstract::Conformational flexibility and structural fluctuations play an important role in enzyme activity. A great variety of internal motions ranging over different time scales and of different amplitudes are involved in the catalytic cycle. These different types of motions and their functional consequences are considered in ...

    journal_title:Biochimie

    pub_type: 杂志文章,评审

    doi:10.1016/s0300-9084(98)80054-0

    authors: Yon JM,Perahia D,Ghélis C

    更新日期:1998-01-01 00:00:00

  • Elongating ribosomes in vivo are refractory to erythromycin.

    abstract::We have studied the kinetics of erythromycin inhibition of translation in growing bacteria. In order to simplify the interpretation of our data, we have used a mutant (envA), known to have an increased permeability to several antibiotics, including erythromycin. The data clearly show that an initial stage of translati...

    journal_title:Biochimie

    pub_type: 杂志文章

    doi:10.1016/0300-9084(87)90218-5

    authors: Andersson S,Kurland CG

    更新日期:1987-08-01 00:00:00