Abstract:
:Natural bovine seminal RNase possesses a potent antitumor action. We have mutagenized monomeric bovine pancreatic RNase A, devoid of any cytotoxic action, to insert residues present at corresponding positions in the subunit of dimeric, antitumor, seminal RNase. Like naturally dimeric seminal RNase, the mutant dimeric RNases display selective toxicity for malignant cells, which is absent in the monomeric mutants.
journal_name
Biochimiejournal_title
Biochimieauthors
Cafaro V,Bracale A,Formiggini F,Notomista E,D'Alessio G,Di Donato Adoi
10.1016/s0300-9084(00)88887-2subject
Has Abstractpub_date
1998-11-01 00:00:00pages
905-9issue
11eissn
0300-9084issn
1638-6183pii
S0300-9084(00)88887-2journal_volume
80pub_type
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