Abstract：
:Non-gonococcal urethritis (NGU) is conventionally treated with oral antibiotics. With this Phase II study, we investigated the action of a locally disinfecting substance, Instillagel, in symptomatic NGU. Instillation treatment was performed twice daily to 32 male patients with symptomatic NGU. To evaluate the therapeutic outcome, a smear was taken from the urethra and an urine examination was performed at baseline as well as at 5 and 8 days after the start of the treatment. Pain and micturition symptoms were determined by a questionnaire with analog scales taken before and after therapy. A pre/post comparison of the urethral smears of the patients with symptomatic NGU showed a significant difference (P < 0.0001). The microbial count in the urine did not show a significant difference. The symptoms micturition (P<0.0001) and pain in the urethra (P<0.0001) were significantly improved. This Phase II study confirmed that local antiseptic treatment of NGU can offer an alternative to systemic antibiotic treatment.
journal_name
World J Uroljournal_title
World journal of urologyauthors
Sperling H,Bastian HP,Boeminghau F,Ludwig G,Terhorst B,Rübben Hdoi
10.1007/s00345-001-0236-1keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
45-7issue
1eissn
0724-4983issn
1433-8726journal_volume
20pub_type
临床试验,杂志文章abstract：PURPOSE:Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) provides reasonable performance in detecting significant cancers. Still, it is unclear about whether all PI-RADS 4 lesions show the same cancer detection rate (CDR) regardless of tumor size. The aim was to compare the CDRs of small (< 10 mm) and l...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02924-2
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Recent studies demonstrated ongoing inverse stage migration in prostate cancer (PCa) patients towards more advanced and unfavorable tumors. The USPSTF grade D recommendation may impact this trend in North American patients. We assessed contemporary stage migration and treatment trends in a large North American ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2396-2
更新日期：2019-03-01 00:00:00
abstract：:The funding number was incorrect in the original published article. The correct funding number should read as follows. ...
journal_title：World journal of urology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00345-018-2289-4
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population. METHODS:Between June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-015-1571-y
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Dhat syndrome (DS) consists of vague somatic symptoms and at times sexual dysfunction which the patient falsely attributes to involuntary emissions of semen outside of sexual relations. OBJECTIVE:Describe and analyse the occurrences of DS in patients attending the clinic and clarify the existence of this co...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-012-0911-4
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:To evaluate whether stone dust can be obtained from all prevailing stone composition types using the thulium fiber laser (TFL) for lithotripsy. Where applicable, stone dust was further characterized by morpho-constitutional analysis. METHODS:Human urinary stones were submitted to in vitro lithotripsy using a F...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03217-9
更新日期：2020-05-03 00:00:00
abstract：PURPOSE:To determine whether individual and/or cumulative components of metabolic syndrome (obesity, hypertension, dyslipidemia, and hyperglycemia) are associated with pathologic features of kidney cancer. PATIENTS AND METHODS:A review of our kidney tumor database identified 462 patients who underwent partial or radic...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-016-1850-2
更新日期：2017-01-01 00:00:00
abstract：:The widespread use of measurement of prostate-specific antigen for prostate cancer screening has led to a dramatic increase in the number of transrectal biopsies. Although transrectal ultrasound-guided prostate biopsy is the gold standard in the diagnosis of prostate cancer, the strategies for initial and repeat biops...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0151-1
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:To assess the effects of warm ischaemia time (WIT) on renal function after laparoscopic partial nephrectomy (LPN) for renal masses in patients with a normal contralateral kidney. METHODS:From October 2006 to December 2008, 53 patients treated with LPN were enrolled in this prospective study. Effective renal pl...
journal_title：World journal of urology
pub_type： 临床试验,杂志文章
doi：10.1007/s00345-011-0729-5
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:Cabazitaxel, a semi-synthetic taxane of the third generation, inhibits prostate cancer (PC) cell growth by affecting the microtubule architecture. Since cabazitaxel has also been demonstrated to inhibit androgen receptor (AR) functionality, AR and AR-associated heat shock protein (HSP) expressions in the presen...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2615-x
更新日期：2019-10-01 00:00:00
abstract：:Vesicoureteral reflux (VUR) represents one of the most significant risk factors for acute pyelonephritis in children. The current indications for the surgical correction of VUR depend on the presence or absence of renal scars. If no scars are present, primary ureteral reimplantation is only indicated in high-grade bil...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-004-0408-x
更新日期：2004-06-01 00:00:00
abstract：OBJECTIVE:It has been hypothesized that endothelial dysfunction and pelvic atherosclerosis may contribute to lower urinary tract symptoms (LUTS). We assessed the relationship between cardiovascular risk factors and LUTS severity in male patients presented to urology clinic. METHODS:It is a cross-sectional study on pat...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-018-2432-2
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:Metastatic renal cell carcinoma (mRCC) represents a significant and rising burden of disease, with rapidly evolving treatment modalities. The role of cytoreductive nephrectomy (CN) is controversial in this setting. As such, London Cancer has pursued a multidisciplinary team (MDT) approach when assessing suitabi...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03107-0
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains c...
journal_title：World journal of urology
pub_type： 杂志文章,meta分析
doi：10.1007/s00345-018-2593-z
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To systematically analyze the impact of prophylactic abdominal or retroperitoneal drain placement or omission in uro-oncologic surgery. METHODS:This systematic review follows the Cochrane recommendations and was conducted in line with the PRISMA and the AMSTAR-II criteria. A comprehensive database search inclu...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02978-2
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:Urethroplasty is the most effective treatment method for anterior urethral strictures, which constitute an important health concern for males. This study aims to investigate factors that may predict treatment failure following urethroplasty for anterior urethral strictures and evaluate outcomes of different ure...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-03014-z
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:The anti-androgen withdrawal syndrome (AAWS) can be seen in one-third of patients after discontinuation of first-generation non-steroidal anti-androgen therapy. With the introduction of new agents for anti-androgen therapy as well as alternate mechanisms of action, new therapeutic options before and after do...
journal_title：World journal of urology
pub_type： 杂志文章,多中心研究
doi：10.1007/s00345-014-1288-3
更新日期：2014-10-01 00:00:00
abstract：OBJECTIVES:To place chemoprevention of prostate cancer in current clinical context. METHODS:Review of recently published updates of large, randomized, controlled trials of primary chemoprevention of prostate cancer. RESULTS:With extended post-intervention follow-up, SELECT demonstrated a 17% increased risk of prostat...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0822-9
更新日期：2012-04-01 00:00:00
abstract：INTRODUCTION:The "trifecta" is a summary measure of outcome after partial nephrectomy (PN) that encompasses three parameters: negative surgical margin, ≤ 10% decrease in post-operative estimated glomerular filtration rate (eGFR) and absence of urological complications. We assessed trifecta rates in patients undergoing ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03349-y
更新日期：2020-07-12 00:00:00
abstract：:Urinary bladder cancer (UBC) ranks ninth in worldwide cancer incidence. It is more frequent in men than in women. We review the main established/proposed factors, both environmental and genetic, associated with bladder cancer etiology and prognosis. Data were extracted from previous reviews and original articles ident...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-007-0168-5
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:Management of male infertility is always a difficult task, with pathophysiology and available treatments often poorly understood. The purpose of this review was to summarize current evidence regarding the use of protective agents against reactive oxygen species (ROS), such as antioxidants that may be useful in ...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02656-3
更新日期：2019-06-01 00:00:00
abstract：:Urinary tract infection (UTI) remains the most common type of infection contracted by kidney transplant patients. UTI reduces both patient and graft survival. Understanding and managing UTI in transplant patients requires an appreciation of their unique anatomy and physiology. Both the transplant and native urinary sy...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-019-02742-6
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:Prostate cancer (PCa) is the most common malignancy in men and the cause for the second most common cancer-related death in the western world. Despite ongoing development of novel approaches such as second generation androgen receptor targeted therapies, metastatic disease is still fatal. In PCa, immunotherapy ...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03497-1
更新日期：2020-10-26 00:00:00
abstract：:We investigated a possible relationship between brefeldin A (BFA), an antibiotic, and cathepsin D (Cat.D), a lysosomal protease, in prostate cancer proliferation. Effects of BFA (30 ng/ml) were examined on the growth of three human prostatic cancer cell lines, PC-3, DU-145, and LNCaP cells. Its effect on Cat.D in thes...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/pl00007099
更新日期：2001-08-01 00:00:00
abstract：PURPOSE:Digital low-dosage, linear slot scanning radiography (Lodox®) is an imaging modality that can emit down to one-tenth the radiation of conventional X-ray systems. We prospectively evaluated Lodox® as a diagnostic imaging modality in patients with ureterolithiasis. METHODS:Conventional kidney-ureter-bladder (KUB...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-019-02803-w
更新日期：2020-04-01 00:00:00
abstract：:The most important phosphates involved in urinary stone disease are carbonate apatite, brushite, and struvite. Overall, phosphate stones account for 12-20% of all stones, with a downward trend for struvite and an increase in carbonate apatite being observed in the last decade. The physicochemical basis for the formati...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s003450050152
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:Living donor nephrectomy is a high-stake procedure involving healthy individuals, therefore every effort should be made to define each patient's individualized risk and improve potential donors' information. The aim of this study was to evaluate the interest of the Mayo adhesive probability (MAP) score, an imag...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/s00345-020-03513-4
更新日期：2020-11-11 00:00:00
abstract：PURPOSE:To evaluate the present human-based evidence that diet is related to the risk and outcome of prostate cancer. METHODS:Review of major case-control and cohort studies, and experimental trials evaluating the effect of diet or dietary constituents on the risk of prostate cancer. RESULTS:Although non-experimental...
journal_title：World journal of urology
pub_type： 杂志文章,评审
doi：10.1007/s00345-011-0810-0
更新日期：2012-04-01 00:00:00
abstract：:Growth and morphogenesis of the prostate involves mesenchymal-epithelial interactions. Transforming growth factor-beta 1 (TGF-beta1) is one growth factor that may play a role in these paracrine interactions. We have localized TGF-beta1 by molecular and immunohistochemical analysis in the developing mouse prostate. Acc...
journal_title：World journal of urology
pub_type： 杂志文章
doi：10.1007/BF00191212
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVES:Nocturia is prevalent and bothersome in men with lower urinary tract symptoms suggestive of BPH (LUTS/BPH). α-Adrenoceptor antagonists without subtype selectivity have inconsistently shown significant effects on nocturia in these patients. We explored the effects of the α1A-adrenoceptor subtype-selective ant...
journal_title：World journal of urology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00345-013-1228-7
更新日期：2014-10-01 00:00:00
